app.py

import glob
import gradio as gr
import matplotlib
import numpy as np
from PIL import Image
import torch
import tempfile
from gradio_imageslider import ImageSlider
import plotly.graph_objects as go
import plotly.express as px
import open3d as o3d
from depth_anything_v2.dpt import DepthAnythingV2
import os
import tensorflow as tf
from tensorflow.keras.models import load_model

# Classification imports
from transformers import AutoImageProcessor, AutoModelForImageClassification
import google.generativeai as genai

import gdown
import spaces
import cv2


# Import actual segmentation model components
from models.deeplab import Deeplabv3, relu6, DepthwiseConv2D, BilinearUpsampling
from utils.learning.metrics import dice_coef, precision, recall
from utils.io.data import normalize

# --- Classification Model Setup ---
# Load classification model and processor
classification_processor = AutoImageProcessor.from_pretrained("Hemg/Wound-classification")
classification_model = AutoModelForImageClassification.from_pretrained("Hemg/Wound-classification")

# Configure Gemini AI
try:
    # Try to get API key from Hugging Face secrets
    gemini_api_key = os.getenv("GOOGLE_API_KEY")
    if not gemini_api_key:
        raise ValueError("GEMINI_API_KEY not found in environment variables")
    
    genai.configure(api_key=gemini_api_key)
    gemini_model = genai.GenerativeModel("gemini-2.5-pro")
    print("✅ Gemini AI configured successfully with API key from secrets")
except Exception as e:
    print(f"❌ Error configuring Gemini AI: {e}")
    print("Please make sure GEMINI_API_KEY is set in your Hugging Face Space secrets")
    gemini_model = None

# --- Classification Functions ---
def analyze_wound_with_gemini(image, predicted_label):
    """
    Analyze wound image using Gemini AI with classification context
    
    Args:
        image: PIL Image
        predicted_label: The predicted wound type from classification model
    
    Returns:
        str: Gemini AI analysis
    """
    if image is None:
        return "No image provided for analysis."
    
    if gemini_model is None:
        return "Gemini AI is not available. Please check that GEMINI_API_KEY is properly configured in your Hugging Face Space secrets."
    
    try:
        # Ensure image is in RGB format
        if image.mode != 'RGB':
            image = image.convert('RGB')
        
        # Create prompt that includes the classification result
        prompt = f"""You are assisting in a medical education and research task. 

Based on the wound classification model, this image has been identified as: {predicted_label}

Please provide an educational analysis of this wound image focusing on:
1. Visible characteristics of the wound (size, color, texture, edges, surrounding tissue)
2. Educational explanation about this type of wound based on the classification: {predicted_label}
3. General wound healing stages if applicable
4. Key features that are typically associated with this wound type

Important guidelines:
- This is for educational and research purposes only
- Do not provide medical advice or diagnosis
- Keep the analysis objective and educational
- Focus on visible features and general wound characteristics
- Do not recommend treatments or medical interventions

Please provide a comprehensive educational analysis."""

        response = gemini_model.generate_content([prompt, image])
        return response.text
        
    except Exception as e:
        return f"Error analyzing image with Gemini: {str(e)}"

def analyze_wound_depth_with_gemini(image, depth_map, depth_stats):
    """
    Analyze wound depth and severity using Gemini AI with depth analysis context
    
    Args:
        image: Original wound image (PIL Image or numpy array)
        depth_map: Depth map (numpy array)
        depth_stats: Dictionary containing depth analysis statistics
    
    Returns:
        str: Gemini AI medical assessment based on depth analysis
    """
    if image is None or depth_map is None:
        return "No image or depth map provided for analysis."
    
    if gemini_model is None:
        return "Gemini AI is not available. Please check that GEMINI_API_KEY is properly configured in your Hugging Face Space secrets."
    
    try:
        # Convert numpy array to PIL Image if needed
        if isinstance(image, np.ndarray):
            image = Image.fromarray(image)
        
        # Ensure image is in RGB format
        if image.mode != 'RGB':
            image = image.convert('RGB')
        
        # Convert depth map to PIL Image for Gemini
        if isinstance(depth_map, np.ndarray):
            # Normalize depth map for visualization
            norm_depth = (depth_map - depth_map.min()) / (depth_map.max() - depth_map.min()) * 255.0
            depth_image = Image.fromarray(norm_depth.astype(np.uint8))
        else:
            depth_image = depth_map
        
        # Create detailed prompt with depth statistics
        prompt = f"""You are a medical AI assistant specializing in wound assessment. Analyze this wound using both the original image and depth map data.

DEPTH ANALYSIS DATA PROVIDED:
- Total Wound Area: {depth_stats['total_area_cm2']:.2f} cm²
- Mean Depth: {depth_stats['mean_depth_mm']:.1f} mm
- Maximum Depth: {depth_stats['max_depth_mm']:.1f} mm
- Depth Standard Deviation: {depth_stats['depth_std_mm']:.1f} mm
- Wound Volume: {depth_stats['wound_volume_cm3']:.2f} cm³
- Deep Tissue Involvement: {depth_stats['deep_ratio']*100:.1f}%
- Analysis Quality: {depth_stats['analysis_quality']}
- Depth Consistency: {depth_stats['depth_consistency']}

TISSUE DEPTH DISTRIBUTION:
- Superficial Areas (0-2mm): {depth_stats['superficial_area_cm2']:.2f} cm²
- Partial Thickness (2-4mm): {depth_stats['partial_thickness_area_cm2']:.2f} cm²
- Full Thickness (4-6mm): {depth_stats['full_thickness_area_cm2']:.2f} cm²
- Deep Areas (>6mm): {depth_stats['deep_area_cm2']:.2f} cm²

STATISTICAL DEPTH ANALYSIS:
- 25th Percentile Depth: {depth_stats['depth_percentiles']['25']:.1f} mm
- Median Depth: {depth_stats['depth_percentiles']['50']:.1f} mm
- 75th Percentile Depth: {depth_stats['depth_percentiles']['75']:.1f} mm

Please provide a comprehensive medical assessment focusing on:

1. **WOUND CHARACTERISTICS ANALYSIS**
   - Visible wound features from the original image
   - Correlation between visual appearance and depth measurements
   - Tissue quality assessment based on color, texture, and depth data

2. **DEPTH-BASED SEVERITY ASSESSMENT**
   - Clinical significance of the measured depths
   - Tissue layer involvement based on depth measurements
   - Risk assessment based on deep tissue involvement percentage

3. **HEALING PROGNOSIS**
   - Expected healing timeline based on depth and area measurements
   - Factors that may affect healing based on depth distribution
   - Complexity assessment based on wound volume and depth variation

4. **CLINICAL CONSIDERATIONS**
   - Significance of depth consistency/inconsistency
   - Areas of particular concern based on depth analysis
   - Educational insights about this type of wound presentation

5. **MEASUREMENT INTERPRETATION**
   - Clinical relevance of the statistical depth measurements
   - What the depth distribution tells us about wound progression
   - Comparison to typical wound depth classifications

IMPORTANT GUIDELINES:
- This is for educational and research purposes only
- Do not provide specific medical advice or treatment recommendations
- Focus on objective analysis of the provided measurements
- Correlate visual findings with quantitative depth data
- Maintain educational and clinical terminology
- Emphasize the relationship between depth measurements and clinical significance

Provide a detailed, structured medical assessment that integrates both visual and quantitative depth analysis."""

        # Send both images to Gemini for analysis
        response = gemini_model.generate_content([prompt, image, depth_image])
        return response.text
        
    except Exception as e:
        return f"Error analyzing wound with Gemini AI: {str(e)}"

def classify_wound(image):
    """
    Classify wound type from uploaded image
    
    Args:
        image: PIL Image or numpy array
    
    Returns:
        dict: Classification results with confidence scores
    """
    if image is None:
        return "Please upload an image"
    
    # Convert to PIL Image if needed
    if isinstance(image, np.ndarray):
        image = Image.fromarray(image)
    
    # Ensure image is in RGB format
    if image.mode != 'RGB':
        image = image.convert('RGB')
    
    try:
        # Process the image
        inputs = classification_processor(images=image, return_tensors="pt")
        
        # Get model predictions
        with torch.no_grad():
            outputs = classification_model(**inputs)
            predictions = torch.nn.functional.softmax(outputs.logits[0], dim=-1)
        
        # Get the predicted class labels and confidence scores
        confidence_scores = predictions.numpy()
        
        # Create results dictionary
        results = {}
        for i, score in enumerate(confidence_scores):
            # Get class name from model config
            class_name = classification_model.config.id2label[i] if hasattr(classification_model.config, 'id2label') else f"Class {i}"
            results[class_name] = float(score)
        
        return results
        
    except Exception as e:
        return f"Error processing image: {str(e)}"

def classify_and_analyze_wound(image):
    """
    Combined function to classify wound and get Gemini analysis
    
    Args:
        image: PIL Image or numpy array
    
    Returns:
        tuple: (classification_results, gemini_analysis)
    """
    if image is None:
        return "Please upload an image", "Please upload an image for analysis"
    
    # Get classification results
    classification_results = classify_wound(image)
    
    # Get the top predicted label for Gemini analysis
    if isinstance(classification_results, dict) and classification_results:
        # Get the label with highest confidence
        top_label = max(classification_results.items(), key=lambda x: x[1])[0]
        
        # Get Gemini analysis
        gemini_analysis = analyze_wound_with_gemini(image, top_label)
    else:
        top_label = "Unknown"
        gemini_analysis = "Unable to analyze due to classification error"
    
    return classification_results, gemini_analysis

def format_gemini_analysis(analysis):
    """Format Gemini analysis as properly structured HTML"""
    if not analysis or "Error" in analysis:
        return f"""
        <div style="
            background-color: #fee2e2;
            border-radius: 12px;
            padding: 16px;
            box-shadow: 0 4px 12px rgba(0,0,0,0.1);
            font-family: Arial, sans-serif;
            min-height: 300px;
            border-left: 4px solid #ef4444;
        ">
            <h4 style="color: #dc2626; margin-top: 0;">Analysis Error</h4>
            <p style="color: #991b1b;">{analysis}</p>
        </div>
        """
    
    # Parse the markdown-style response and convert to HTML
    formatted_analysis = parse_markdown_to_html(analysis)
    
    return f"""
    <div style="
        border-radius: 12px;
        padding: 25px;
        box-shadow: 0 4px 12px rgba(0,0,0,0.1);
        font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif;
        min-height: 300px;
        border-left: 4px solid #d97706;
        max-height: 600px;
        overflow-y: auto;
    ">
        <h3 style="color: #d97706; margin-top: 0; margin-bottom: 20px; display: flex; align-items: center; gap: 8px;">
            Initial Wound Analysis
        </h3>
        <div style="color: white; line-height: 1.7;">
            {formatted_analysis}
        </div>
    </div>
    """

def format_gemini_depth_analysis(analysis):
    """Format Gemini depth analysis as properly structured HTML for medical assessment"""
    if not analysis or "Error" in analysis:
        return f"""
        <div style="color: #ffffff; line-height: 1.6;">
            <div style="font-size: 16px; font-weight: bold; margin-bottom: 10px; color: #f44336;">
                ❌ AI Analysis Error
            </div>
            <div style="color: #cccccc;">
                {analysis}
            </div>
        </div>
        """
    
    # Parse the markdown-style response and convert to HTML
    formatted_analysis = parse_markdown_to_html(analysis)
    
    return f"""
    <div style="color: #ffffff; line-height: 1.6;">
        <div style="font-size: 16px; font-weight: bold; margin-bottom: 15px; color: #4CAF50;">
            🤖 AI-Powered Medical Assessment
        </div>
        <div style="color: #cccccc; max-height: 400px; overflow-y: auto; padding-right: 10px;">
            {formatted_analysis}
        </div>
    </div>
    """

def parse_markdown_to_html(text):
    """Convert markdown-style text to HTML"""
    import re
    
    # Replace markdown headers
    text = re.sub(r'^### \*\*(.*?)\*\*$', r'<h4 style="color: #d97706; margin: 20px 0 10px 0; font-weight: bold;">\1</h4>', text, flags=re.MULTILINE)
    text = re.sub(r'^#### \*\*(.*?)\*\*$', r'<h5 style="color: #f59e0b; margin: 15px 0 8px 0; font-weight: bold;">\1</h5>', text, flags=re.MULTILINE)
    text = re.sub(r'^### (.*?)$', r'<h4 style="color: #d97706; margin: 20px 0 10px 0; font-weight: bold;">\1</h4>', text, flags=re.MULTILINE)
    text = re.sub(r'^#### (.*?)$', r'<h5 style="color: #f59e0b; margin: 15px 0 8px 0; font-weight: bold;">\1</h5>', text, flags=re.MULTILINE)
    
    # Replace bold text
    text = re.sub(r'\*\*(.*?)\*\*', r'<strong style="color: #fbbf24;">\1</strong>', text)
    
    # Replace italic text
    text = re.sub(r'\*(.*?)\*', r'<em style="color: #fde68a;">\1</em>', text)
    
    # Replace bullet points
    text = re.sub(r'^\*   (.*?)$', r'<li style="margin: 5px 0; color: white;">\1</li>', text, flags=re.MULTILINE)
    text = re.sub(r'^    \*   (.*?)$', r'<li style="margin: 3px 0; margin-left: 20px; color: white;">\1</li>', text, flags=re.MULTILINE)
    
    # Wrap consecutive list items in ul tags
    text = re.sub(r'(<li.*?</li>(?:\s*<li.*?</li>)*)', r'<ul style="margin: 10px 0; padding-left: 20px;">\1</ul>', text, flags=re.DOTALL)
    
    # Replace numbered lists
    text = re.sub(r'^(\d+)\.\s+(.*?)$', r'<div style="margin: 8px 0; color: white;"><strong style="color: #d97706;">\1.</strong> \2</div>', text, flags=re.MULTILINE)
    
    # Convert paragraphs (double newlines)
    paragraphs = text.split('\n\n')
    formatted_paragraphs = []
    
    for para in paragraphs:
        para = para.strip()
        if para:
            # Skip if it's already wrapped in HTML tags
            if not (para.startswith('<') or para.endswith('>')):
                para = f'<p style="margin: 12px 0; color: white; text-align: justify;">{para}</p>'
            formatted_paragraphs.append(para)
    
    return '\n'.join(formatted_paragraphs)

def combined_analysis(image):
    """Combined function for UI that returns both outputs"""
    classification, gemini_analysis = classify_and_analyze_wound(image)
    formatted_analysis = format_gemini_analysis(gemini_analysis)
    return classification, formatted_analysis





# Define path and file ID
checkpoint_dir = "checkpoints"
os.makedirs(checkpoint_dir, exist_ok=True)

model_file = os.path.join(checkpoint_dir, "depth_anything_v2_vitl.pth")
gdrive_url = "https://drive.google.com/uc?id=1tfNiBCB2-yF1xtHU5KzCJOlwMs20v1_E"

# Download if not already present
if not os.path.exists(model_file):
    print("Downloading model from Google Drive...")
    gdown.download(gdrive_url, model_file, quiet=False)

# --- TensorFlow: Check GPU Availability ---
gpus = tf.config.list_physical_devices('GPU')
if gpus:
    print("TensorFlow is using GPU")
else:
    print("TensorFlow is using CPU")



# --- Load Actual Wound Segmentation Model ---
class WoundSegmentationModel:
    def __init__(self):
        self.input_dim_x = 224
        self.input_dim_y = 224
        self.model = None
        self.load_model()
    
    def load_model(self):
        """Load the trained wound segmentation model"""
        try:
            # Try to load the most recent model
            weight_file_name = '2025-08-07_16-25-27.hdf5'
            model_path = f'./training_history/{weight_file_name}'
            
            self.model = load_model(model_path, 
                                  custom_objects={
                                      'recall': recall,
                                      'precision': precision,
                                      'dice_coef': dice_coef,
                                      'relu6': relu6,
                                      'DepthwiseConv2D': DepthwiseConv2D,
                                      'BilinearUpsampling': BilinearUpsampling
                                  })
            print(f"Segmentation model loaded successfully from {model_path}")
        except Exception as e:
            print(f"Error loading segmentation model: {e}")
            # Fallback to the older model
            try:
                weight_file_name = '2019-12-19 01%3A53%3A15.480800.hdf5'
                model_path = f'./training_history/{weight_file_name}'
                
                self.model = load_model(model_path, 
                                      custom_objects={
                                          'recall': recall,
                                          'precision': precision,
                                          'dice_coef': dice_coef,
                                          'relu6': relu6,
                                          'DepthwiseConv2D': DepthwiseConv2D,
                                          'BilinearUpsampling': BilinearUpsampling
                                      })
                print(f"Segmentation model loaded successfully from {model_path}")
            except Exception as e2:
                print(f"Error loading fallback segmentation model: {e2}")
                self.model = None
    
    def preprocess_image(self, image):
        """Preprocess the uploaded image for model input"""
        if image is None:
            return None
        
        # Convert to RGB if needed
        if len(image.shape) == 3 and image.shape[2] == 3:
            # Convert BGR to RGB if needed
            image = cv2.cvtColor(image, cv2.COLOR_BGR2RGB)
        
        # Resize to model input size
        image = cv2.resize(image, (self.input_dim_x, self.input_dim_y))
        
        # Normalize the image
        image = image.astype(np.float32) / 255.0
        
        # Add batch dimension
        image = np.expand_dims(image, axis=0)
        
        return image
    
    def postprocess_prediction(self, prediction):
        """Postprocess the model prediction"""
        # Remove batch dimension
        prediction = prediction[0]
        
        # Apply threshold to get binary mask
        threshold = 0.5
        binary_mask = (prediction > threshold).astype(np.uint8) * 255
        
        return binary_mask
    
    def segment_wound(self, input_image):
        """Main function to segment wound from uploaded image"""
        if self.model is None:
            return None, "Error: Segmentation model not loaded. Please check the model files."
        
        if input_image is None:
            return None, "Please upload an image."
        
        try:
            # Preprocess the image
            processed_image = self.preprocess_image(input_image)
            
            if processed_image is None:
                return None, "Error processing image."
            
            # Make prediction
            prediction = self.model.predict(processed_image, verbose=0)
            
            # Postprocess the prediction
            segmented_mask = self.postprocess_prediction(prediction)
            
            return segmented_mask, "Segmentation completed successfully!"
            
        except Exception as e:
            return None, f"Error during segmentation: {str(e)}"

# Initialize the segmentation model
segmentation_model = WoundSegmentationModel()

# --- PyTorch: Set Device and Load Depth Model ---
map_device = torch.device("cuda" if torch.cuda.is_available() and torch.cuda.device_count() > 0 else "cpu")
print(f"Using PyTorch device: {map_device}")

model_configs = {
    'vits': {'encoder': 'vits', 'features': 64, 'out_channels': [48, 96, 192, 384]},
    'vitb': {'encoder': 'vitb', 'features': 128, 'out_channels': [96, 192, 384, 768]},
    'vitl': {'encoder': 'vitl', 'features': 256, 'out_channels': [256, 512, 1024, 1024]},
    'vitg': {'encoder': 'vitg', 'features': 384, 'out_channels': [1536, 1536, 1536, 1536]}
}
encoder = 'vitl'
depth_model = DepthAnythingV2(**model_configs[encoder])
state_dict = torch.load(
    f'checkpoints/depth_anything_v2_{encoder}.pth',
    map_location=map_device
)
depth_model.load_state_dict(state_dict)
depth_model = depth_model.to(map_device).eval()


# --- Custom CSS for unified dark theme ---
css = """
.gradio-container {
    font-family: 'Segoe UI', sans-serif;
    background-color: #121212;
    color: #ffffff;
    padding: 20px;
}
.gr-button {
    background-color: #2c3e50;
    color: white;
    border-radius: 10px;
}
.gr-button:hover {
    background-color: #34495e;
}
.gr-html, .gr-html div {
    white-space: normal !important;
    overflow: visible !important;
    text-overflow: unset !important;
    word-break: break-word !important;
}
#img-display-container {
    max-height: 100vh;
}
#img-display-input {
    max-height: 80vh;
}
#img-display-output {
    max-height: 80vh;
}
#download {
    height: 62px;
}
h1 {
    text-align: center;
    font-size: 3rem;
    font-weight: bold;
    margin: 2rem 0;
    color: #ffffff;
}
h2 {
    color: #ffffff;
    text-align: center;
    margin: 1rem 0;
}
.gr-tabs {
    background-color: #1e1e1e;
    border-radius: 10px;
    padding: 10px;
}
.gr-tab-nav {
    background-color: #2c3e50;
    border-radius: 8px;
}
.gr-tab-nav button {
    color: #ffffff !important;
}
.gr-tab-nav button.selected {
    background-color: #34495e !important;
}
/* Card styling for consistent heights */
.wound-card {
    min-height: 200px !important;
    display: flex !important;
    flex-direction: column !important;
    justify-content: space-between !important;
}
.wound-card-content {
    flex-grow: 1 !important;
    display: flex !important;
    flex-direction: column !important;
    justify-content: center !important;
}
/* Loading animation */
.loading-spinner {
    display: inline-block;
    width: 20px;
    height: 20px;
    border: 3px solid #f3f3f3;
    border-top: 3px solid #3498db;
    border-radius: 50%;
    animation: spin 1s linear infinite;
}
@keyframes spin {
    0% { transform: rotate(0deg); }
    100% { transform: rotate(360deg); }
}
"""





# --- Enhanced Wound Severity Estimation Functions ---

def compute_enhanced_depth_statistics(depth_map, mask, pixel_spacing_mm=0.5, depth_calibration_mm=15.0):
    """
    Enhanced depth analysis with proper calibration and medical standards
    Based on wound depth classification standards:
    - Superficial: 0-2mm (epidermis only)
    - Partial thickness: 2-4mm (epidermis + partial dermis)
    - Full thickness: 4-6mm (epidermis + full dermis)
    - Deep: >6mm (involving subcutaneous tissue)
    """
    # Convert pixel spacing to mm
    pixel_spacing_mm = float(pixel_spacing_mm)
    
    # Calculate pixel area in cm²
    pixel_area_cm2 = (pixel_spacing_mm / 10.0) ** 2
    
    # Extract wound region (binary mask)
    wound_mask = (mask > 127).astype(np.uint8)
    
    # Apply morphological operations to clean the mask
    kernel = cv2.getStructuringElement(cv2.MORPH_ELLIPSE, (3, 3))
    wound_mask = cv2.morphologyEx(wound_mask, cv2.MORPH_CLOSE, kernel)
    
    # Get depth values only for wound region
    wound_depths = depth_map[wound_mask > 0]
    
    if len(wound_depths) == 0:
        return {
            'total_area_cm2': 0,
            'superficial_area_cm2': 0,
            'partial_thickness_area_cm2': 0,
            'full_thickness_area_cm2': 0,
            'deep_area_cm2': 0,
            'mean_depth_mm': 0,
            'max_depth_mm': 0,
            'depth_std_mm': 0,
            'deep_ratio': 0,
            'wound_volume_cm3': 0,
            'depth_percentiles': {'25': 0, '50': 0, '75': 0}
        }
    
    # Normalize depth relative to nearest point in wound area
    normalized_depth_map, nearest_point_coords, max_relative_depth = normalize_depth_relative_to_nearest_point(depth_map, wound_mask)
    
    # Calibrate the normalized depth map for more accurate measurements
    calibrated_depth_map = calibrate_depth_map(normalized_depth_map, reference_depth_mm=depth_calibration_mm)
    
    # Get calibrated depth values for wound region
    wound_depths_mm = calibrated_depth_map[wound_mask > 0]
    
    # Medical depth classification
    superficial_mask = wound_depths_mm < 2.0
    partial_thickness_mask = (wound_depths_mm >= 2.0) & (wound_depths_mm < 4.0)
    full_thickness_mask = (wound_depths_mm >= 4.0) & (wound_depths_mm < 6.0)
    deep_mask = wound_depths_mm >= 6.0
    
    # Calculate areas
    total_pixels = np.sum(wound_mask > 0)
    total_area_cm2 = total_pixels * pixel_area_cm2
    
    superficial_area_cm2 = np.sum(superficial_mask) * pixel_area_cm2
    partial_thickness_area_cm2 = np.sum(partial_thickness_mask) * pixel_area_cm2
    full_thickness_area_cm2 = np.sum(full_thickness_mask) * pixel_area_cm2
    deep_area_cm2 = np.sum(deep_mask) * pixel_area_cm2
    
    # Calculate depth statistics
    mean_depth_mm = np.mean(wound_depths_mm)
    max_depth_mm = np.max(wound_depths_mm)
    depth_std_mm = np.std(wound_depths_mm)
    
    # Calculate depth percentiles
    depth_percentiles = {
        '25': np.percentile(wound_depths_mm, 25),
        '50': np.percentile(wound_depths_mm, 50),
        '75': np.percentile(wound_depths_mm, 75)
    }
    
    # Calculate depth distribution statistics
    depth_distribution = {
        'shallow_ratio': np.sum(wound_depths_mm < 2.0) / len(wound_depths_mm) if len(wound_depths_mm) > 0 else 0,
        'moderate_ratio': np.sum((wound_depths_mm >= 2.0) & (wound_depths_mm < 5.0)) / len(wound_depths_mm) if len(wound_depths_mm) > 0 else 0,
        'deep_ratio': np.sum(wound_depths_mm >= 5.0) / len(wound_depths_mm) if len(wound_depths_mm) > 0 else 0
    }
    
    # Calculate wound volume (approximate)
    # Volume = area * average depth
    wound_volume_cm3 = total_area_cm2 * (mean_depth_mm / 10.0)
    
    # Deep tissue ratio
    deep_ratio = deep_area_cm2 / total_area_cm2 if total_area_cm2 > 0 else 0
    
    # Calculate analysis quality metrics
    wound_pixel_count = len(wound_depths_mm)
    analysis_quality = "High" if wound_pixel_count > 1000 else "Medium" if wound_pixel_count > 500 else "Low"
    
    # Calculate depth consistency (lower std dev = more consistent)
    depth_consistency = "High" if depth_std_mm < 2.0 else "Medium" if depth_std_mm < 4.0 else "Low"
    
    return {
        'total_area_cm2': total_area_cm2,
        'superficial_area_cm2': superficial_area_cm2,
        'partial_thickness_area_cm2': partial_thickness_area_cm2,
        'full_thickness_area_cm2': full_thickness_area_cm2,
        'deep_area_cm2': deep_area_cm2,
        'mean_depth_mm': mean_depth_mm,
        'max_depth_mm': max_depth_mm,
        'depth_std_mm': depth_std_mm,
        'deep_ratio': deep_ratio,
        'wound_volume_cm3': wound_volume_cm3,
        'depth_percentiles': depth_percentiles,
        'depth_distribution': depth_distribution,
        'analysis_quality': analysis_quality,
        'depth_consistency': depth_consistency,
        'wound_pixel_count': wound_pixel_count,
        'nearest_point_coords': nearest_point_coords,
        'max_relative_depth': max_relative_depth,
        'normalized_depth_map': normalized_depth_map
    }

def classify_wound_severity_by_enhanced_metrics(depth_stats):
    """
    Enhanced wound severity classification based on medical standards
    Uses multiple criteria: depth, area, volume, and tissue involvement
    """
    if depth_stats['total_area_cm2'] == 0:
        return "Unknown"
    
    # Extract key metrics
    total_area = depth_stats['total_area_cm2']
    deep_area = depth_stats['deep_area_cm2']
    full_thickness_area = depth_stats['full_thickness_area_cm2']
    mean_depth = depth_stats['mean_depth_mm']
    max_depth = depth_stats['max_depth_mm']
    wound_volume = depth_stats['wound_volume_cm3']
    deep_ratio = depth_stats['deep_ratio']
    
    # Medical severity classification criteria
    severity_score = 0
    
    # Criterion 1: Maximum depth
    if max_depth >= 10.0:
        severity_score += 3  # Very severe
    elif max_depth >= 6.0:
        severity_score += 2  # Severe
    elif max_depth >= 4.0:
        severity_score += 1  # Moderate
    
    # Criterion 2: Mean depth
    if mean_depth >= 5.0:
        severity_score += 2
    elif mean_depth >= 3.0:
        severity_score += 1
    
    # Criterion 3: Deep tissue involvement ratio
    if deep_ratio >= 0.5:
        severity_score += 3  # More than 50% deep tissue
    elif deep_ratio >= 0.25:
        severity_score += 2  # 25-50% deep tissue
    elif deep_ratio >= 0.1:
        severity_score += 1  # 10-25% deep tissue
    
    # Criterion 4: Total wound area
    if total_area >= 10.0:
        severity_score += 2  # Large wound (>10 cm²)
    elif total_area >= 5.0:
        severity_score += 1  # Medium wound (5-10 cm²)
    
    # Criterion 5: Wound volume
    if wound_volume >= 5.0:
        severity_score += 2  # High volume
    elif wound_volume >= 2.0:
        severity_score += 1  # Medium volume
    
    # Determine severity based on total score
    if severity_score >= 8:
        return "Very Severe"
    elif severity_score >= 6:
        return "Severe"
    elif severity_score >= 4:
        return "Moderate"
    elif severity_score >= 2:
        return "Mild"
    else:
        return "Superficial"





def analyze_wound_severity(image, depth_map, wound_mask, pixel_spacing_mm=0.5, depth_calibration_mm=15.0):
    """Enhanced wound severity analysis based on depth measurements"""
    if image is None or depth_map is None or wound_mask is None:
        return "❌ Please upload image, depth map, and wound mask."

    # Convert wound mask to grayscale if needed
    if len(wound_mask.shape) == 3:
        wound_mask = np.mean(wound_mask, axis=2)

    # Ensure depth map and mask have same dimensions
    if depth_map.shape[:2] != wound_mask.shape[:2]:
        # Resize mask to match depth map
        from PIL import Image
        mask_pil = Image.fromarray(wound_mask.astype(np.uint8))
        mask_pil = mask_pil.resize((depth_map.shape[1], depth_map.shape[0]))
        wound_mask = np.array(mask_pil)

    # Compute enhanced statistics with relative depth normalization
    stats = compute_enhanced_depth_statistics(depth_map, wound_mask, pixel_spacing_mm, depth_calibration_mm)
    
    # Get severity based on enhanced metrics
    severity_level = classify_wound_severity_by_enhanced_metrics(stats)
    severity_description = get_enhanced_severity_description(severity_level)
    
    # Get Gemini AI analysis based on depth data
    gemini_analysis = analyze_wound_depth_with_gemini(image, depth_map, stats)
    
    # Format Gemini analysis for display
    formatted_gemini_analysis = format_gemini_depth_analysis(gemini_analysis)
    
    # Create depth analysis visualization
    depth_visualization = create_depth_analysis_visualization(
        stats['normalized_depth_map'], wound_mask, 
        stats['nearest_point_coords'], stats['max_relative_depth']
    )

    # Enhanced severity color coding
    severity_color = {
        "Superficial": "#4CAF50",    # Green
        "Mild": "#8BC34A",           # Light Green
        "Moderate": "#FF9800",       # Orange
        "Severe": "#F44336",         # Red
        "Very Severe": "#9C27B0"     # Purple
    }.get(severity_level, "#9E9E9E")    # Gray for unknown

    # Create comprehensive medical report
    report = f"""
    <div style='padding: 20px; background-color: #1e1e1e; border-radius: 12px; box-shadow: 0 0 10px rgba(0,0,0,0.5);'>
        <div style='font-size: 24px; font-weight: bold; color: {severity_color}; margin-bottom: 15px;'>
            🩹 Enhanced Wound Severity Analysis
        </div>

        <div style='background-color: #2c2c2c; padding: 15px; border-radius: 8px; margin-bottom: 20px;'>
            <div style='font-size: 18px; font-weight: bold; color: #ffffff; margin-bottom: 15px; text-align: center;'>
                📊 Depth & Quality Analysis
            </div>
            <div style='color: #cccccc; line-height: 1.6; display: grid; grid-template-columns: 1fr 1fr 1fr; gap: 20px;'>
                <div>
                    <div style='font-size: 16px; font-weight: bold; color: #ff9800; margin-bottom: 8px;'>� Basic Measurements</div>
                    <div>�📏 <b>Mean Relative Depth:</b> {stats['mean_depth_mm']:.1f} mm</div>
                    <div>📐 <b>Max Relative Depth:</b> {stats['max_depth_mm']:.1f} mm</div>
                    <div>📊 <b>Depth Std Dev:</b> {stats['depth_std_mm']:.1f} mm</div>
                    <div>📦 <b>Wound Volume:</b> {stats['wound_volume_cm3']:.2f} cm³</div>
                    <div>🔥 <b>Deep Tissue Ratio:</b> {stats['deep_ratio']*100:.1f}%</div>
                </div>
                <div>
                    <div style='font-size: 16px; font-weight: bold; color: #4CAF50; margin-bottom: 8px;'>📈 Statistical Analysis</div>
                    <div>� <b>25th Percentile:</b> {stats['depth_percentiles']['25']:.1f} mm</div>
                    <div>📊 <b>Median (50th):</b> {stats['depth_percentiles']['50']:.1f} mm</div>
                    <div>📊 <b>75th Percentile:</b> {stats['depth_percentiles']['75']:.1f} mm</div>
                    <div>📊 <b>Shallow Areas:</b> {stats['depth_distribution']['shallow_ratio']*100:.1f}%</div>
                    <div>📊 <b>Moderate Areas:</b> {stats['depth_distribution']['moderate_ratio']*100:.1f}%</div>
                </div>
                <div>
                    <div style='font-size: 16px; font-weight: bold; color: #2196F3; margin-bottom: 8px;'>🔍 Quality Metrics</div>
                    <div>🔍 <b>Analysis Quality:</b> {stats['analysis_quality']}</div>
                    <div>📏 <b>Depth Consistency:</b> {stats['depth_consistency']}</div>
                    <div>📊 <b>Data Points:</b> {stats['wound_pixel_count']:,}</div>
                    <div>📊 <b>Deep Areas:</b> {stats['depth_distribution']['deep_ratio']*100:.1f}%</div>
                    <div>🎯 <b>Reference Point:</b> Nearest to camera</div>
                </div>
            </div>
        </div>

        <div style='background-color: #2c2c2c; padding: 15px; border-radius: 8px; margin-bottom: 20px; border-left: 4px solid {severity_color};'>
            <div style='font-size: 18px; font-weight: bold; color: {severity_color}; margin-bottom: 10px;'>
                📊 Medical Assessment Based on Depth Analysis
            </div>
            {formatted_gemini_analysis}
        </div>
    </div>
    """

    return report

def normalize_depth_relative_to_nearest_point(depth_map, wound_mask):
    """
    Normalize depth map relative to the nearest point in the wound area
    This assumes a top-down camera perspective where the closest point to camera = 0 depth
    
    Args:
        depth_map: Raw depth map
        wound_mask: Binary mask of wound region
    
    Returns:
        normalized_depth: Depth values relative to nearest point (0 = nearest, positive = deeper)
        nearest_point_coords: Coordinates of the nearest point
        max_relative_depth: Maximum relative depth in the wound
    """
    if depth_map is None or wound_mask is None:
        return depth_map, None, 0
    
    # Convert mask to binary
    binary_mask = (wound_mask > 127).astype(np.uint8)
    
    # Find wound region coordinates
    wound_coords = np.where(binary_mask > 0)
    
    if len(wound_coords[0]) == 0:
        return depth_map, None, 0
    
    # Get depth values only for wound region
    wound_depths = depth_map[wound_coords]
    
    # Find the nearest point (minimum depth value in wound region)
    nearest_depth = np.min(wound_depths)
    nearest_indices = np.where(wound_depths == nearest_depth)
    
    # Get coordinates of the nearest point(s)
    nearest_point_coords = (wound_coords[0][nearest_indices[0][0]], 
                           wound_coords[1][nearest_indices[0][0]])
    
    # Create normalized depth map (relative to nearest point)
    normalized_depth = depth_map.copy()
    normalized_depth = normalized_depth - nearest_depth
    
    # Ensure all values are non-negative (nearest point = 0, others = positive)
    normalized_depth = np.maximum(normalized_depth, 0)
    
    # Calculate maximum relative depth in wound region
    wound_normalized_depths = normalized_depth[wound_coords]
    max_relative_depth = np.max(wound_normalized_depths)
    
    return normalized_depth, nearest_point_coords, max_relative_depth

def calibrate_depth_map(depth_map, reference_depth_mm=10.0):
    """
    Calibrate depth map to real-world measurements using reference depth
    This helps convert normalized depth values to actual millimeters
    """
    if depth_map is None:
        return depth_map
    
    # Find the maximum depth value in the depth map
    max_depth_value = np.max(depth_map)
    min_depth_value = np.min(depth_map)
    
    if max_depth_value == min_depth_value:
        return depth_map
    
    # Apply calibration to convert to millimeters
    # Assuming the maximum depth in the map corresponds to reference_depth_mm
    calibrated_depth = (depth_map - min_depth_value) / (max_depth_value - min_depth_value) * reference_depth_mm
    
    return calibrated_depth

def create_depth_analysis_visualization(depth_map, wound_mask, nearest_point_coords, max_relative_depth):
    """
    Create a visualization showing the depth analysis with nearest point and deepest point highlighted
    """
    if depth_map is None or wound_mask is None:
        return None
    
    # Create a copy of the depth map for visualization
    vis_depth = depth_map.copy()
    
    # Apply colormap for better visualization
    normalized_depth = (vis_depth - np.min(vis_depth)) / (np.max(vis_depth) - np.min(vis_depth))
    colored_depth = (matplotlib.colormaps.get_cmap('Spectral_r')(normalized_depth)[:, :, :3] * 255).astype(np.uint8)
    
    # Convert to RGB if grayscale
    if len(colored_depth.shape) == 3 and colored_depth.shape[2] == 1:
        colored_depth = cv2.cvtColor(colored_depth, cv2.COLOR_GRAY2RGB)
    
    # Highlight the nearest point (reference point) with a red circle
    if nearest_point_coords is not None:
        y, x = nearest_point_coords
        cv2.circle(colored_depth, (x, y), 10, (255, 0, 0), 2)  # Red circle for nearest point
        cv2.putText(colored_depth, "REF", (x+15, y-5), cv2.FONT_HERSHEY_SIMPLEX, 0.5, (255, 0, 0), 1)
    
    # Find and highlight the deepest point
    binary_mask = (wound_mask > 127).astype(np.uint8)
    wound_coords = np.where(binary_mask > 0)
    
    if len(wound_coords[0]) > 0:
        # Get depth values for wound region
        wound_depths = vis_depth[wound_coords]
        max_depth_idx = np.argmax(wound_depths)
        deepest_point_coords = (wound_coords[0][max_depth_idx], wound_coords[1][max_depth_idx])
        
        # Highlight the deepest point with a blue circle
        y, x = deepest_point_coords
        cv2.circle(colored_depth, (x, y), 12, (0, 0, 255), 3)  # Blue circle for deepest point
        cv2.putText(colored_depth, "DEEP", (x+15, y+5), cv2.FONT_HERSHEY_SIMPLEX, 0.5, (0, 0, 255), 1)
    
    # Overlay wound mask outline
    contours, _ = cv2.findContours(binary_mask, cv2.RETR_EXTERNAL, cv2.CHAIN_APPROX_SIMPLE)
    cv2.drawContours(colored_depth, contours, -1, (0, 255, 0), 2)  # Green outline for wound boundary
    
    return colored_depth

def get_enhanced_severity_description(severity):
    """Get comprehensive medical description for severity level"""
    descriptions = {
        "Superficial": "Epidermis-only damage. Minimal tissue loss, typically heals within 1-2 weeks with basic wound care.",
        "Mild": "Superficial to partial thickness wound. Limited tissue involvement, good healing potential with proper care.",
        "Moderate": "Partial to full thickness involvement. Requires careful monitoring and may need advanced wound care techniques.",
        "Severe": "Full thickness with deep tissue involvement. High risk of complications, requires immediate medical attention.",
        "Very Severe": "Extensive deep tissue damage. Critical condition requiring immediate surgical intervention and specialized care.",
        "Unknown": "Unable to determine severity due to insufficient data or poor image quality."
    }
    return descriptions.get(severity, "Severity assessment unavailable.")

def create_sample_wound_mask(image_shape, center=None, radius=50):
    """Create a sample circular wound mask for testing"""
    if center is None:
        center = (image_shape[1] // 2, image_shape[0] // 2)

    mask = np.zeros(image_shape[:2], dtype=np.uint8)
    y, x = np.ogrid[:image_shape[0], :image_shape[1]]

    # Create circular mask
    dist_from_center = np.sqrt((x - center[0])**2 + (y - center[1])**2)
    mask[dist_from_center <= radius] = 255

    return mask

def create_realistic_wound_mask(image_shape, method='elliptical'):
    """Create a more realistic wound mask with irregular shapes"""
    h, w = image_shape[:2]
    mask = np.zeros((h, w), dtype=np.uint8)

    if method == 'elliptical':
        # Create elliptical wound mask
        center = (w // 2, h // 2)
        radius_x = min(w, h) // 3
        radius_y = min(w, h) // 4

        y, x = np.ogrid[:h, :w]
        # Add some irregularity to make it more realistic
        ellipse = ((x - center[0])**2 / (radius_x**2) +
                   (y - center[1])**2 / (radius_y**2)) <= 1

        # Add some noise and irregularity
        noise = np.random.random((h, w)) > 0.8
        mask = (ellipse | noise).astype(np.uint8) * 255

    elif method == 'irregular':
        # Create irregular wound mask
        center = (w // 2, h // 2)
        radius = min(w, h) // 4

        y, x = np.ogrid[:h, :w]
        base_circle = np.sqrt((x - center[0])**2 + (y - center[1])**2) <= radius

        # Add irregular extensions
        extensions = np.zeros_like(base_circle)
        for i in range(3):
            angle = i * 2 * np.pi / 3
            ext_x = int(center[0] + radius * 0.8 * np.cos(angle))
            ext_y = int(center[1] + radius * 0.8 * np.sin(angle))
            ext_radius = radius // 3

            ext_circle = np.sqrt((x - ext_x)**2 + (y - ext_y)**2) <= ext_radius
            extensions = extensions | ext_circle

        mask = (base_circle | extensions).astype(np.uint8) * 255

    # Apply morphological operations to smooth the mask
    kernel = cv2.getStructuringElement(cv2.MORPH_ELLIPSE, (5, 5))
    mask = cv2.morphologyEx(mask, cv2.MORPH_CLOSE, kernel)

    return mask

# --- Depth Estimation Functions ---

def predict_depth(image):
    return depth_model.infer_image(image)

def calculate_max_points(image):
    """Calculate maximum points based on image dimensions (3x pixel count)"""
    if image is None:
        return 10000  # Default value
    h, w = image.shape[:2]
    max_points = h * w * 3
    # Ensure minimum and reasonable maximum values
    return max(1000, min(max_points, 300000))

def update_slider_on_image_upload(image):
    """Update the points slider when an image is uploaded"""
    max_points = calculate_max_points(image)
    default_value = min(10000, max_points // 10)  # 10% of max points as default
    return gr.Slider(minimum=1000, maximum=max_points, value=default_value, step=1000,
                     label=f"Number of 3D points (max: {max_points:,})")


def create_point_cloud(image, depth_map, focal_length_x=470.4, focal_length_y=470.4, max_points=30000):
    """Create a point cloud from depth map using camera intrinsics with high detail"""
    h, w = depth_map.shape

    # Use smaller step for higher detail (reduced downsampling)
    step = max(1, int(np.sqrt(h * w / max_points) * 0.5))  # Reduce step size for more detail

    # Create mesh grid for camera coordinates
    y_coords, x_coords = np.mgrid[0:h:step, 0:w:step]

    # Convert to camera coordinates (normalized by focal length)
    x_cam = (x_coords - w / 2) / focal_length_x
    y_cam = (y_coords - h / 2) / focal_length_y

    # Get depth values
    depth_values = depth_map[::step, ::step]

    # Calculate 3D points: (x_cam * depth, y_cam * depth, depth)
    x_3d = x_cam * depth_values
    y_3d = y_cam * depth_values
    z_3d = depth_values

    # Flatten arrays
    points = np.stack([x_3d.flatten(), y_3d.flatten(), z_3d.flatten()], axis=1)

    # Get corresponding image colors
    image_colors = image[::step, ::step, :]
    colors = image_colors.reshape(-1, 3) / 255.0

    # Create Open3D point cloud
    pcd = o3d.geometry.PointCloud()
    pcd.points = o3d.utility.Vector3dVector(points)
    pcd.colors = o3d.utility.Vector3dVector(colors)

    return pcd


def reconstruct_surface_mesh_from_point_cloud(pcd):
    """Convert point cloud to a mesh using Poisson reconstruction with very high detail."""
    # Estimate and orient normals with high precision
    pcd.estimate_normals(search_param=o3d.geometry.KDTreeSearchParamHybrid(radius=0.005, max_nn=50))
    pcd.orient_normals_consistent_tangent_plane(k=50)

    # Create surface mesh with maximum detail (depth=12 for very high resolution)
    mesh, densities = o3d.geometry.TriangleMesh.create_from_point_cloud_poisson(pcd, depth=12)

    # Return mesh without filtering low-density vertices
    return mesh


def create_enhanced_3d_visualization(image, depth_map, max_points=10000):
    """Create an enhanced 3D visualization using proper camera projection"""
    h, w = depth_map.shape

    # Downsample to avoid too many points for performance
    step = max(1, int(np.sqrt(h * w / max_points)))

    # Create mesh grid for camera coordinates
    y_coords, x_coords = np.mgrid[0:h:step, 0:w:step]

    # Convert to camera coordinates (normalized by focal length)
    focal_length = 470.4  # Default focal length
    x_cam = (x_coords - w / 2) / focal_length
    y_cam = (y_coords - h / 2) / focal_length

    # Get depth values
    depth_values = depth_map[::step, ::step]

    # Calculate 3D points: (x_cam * depth, y_cam * depth, depth)
    x_3d = x_cam * depth_values
    y_3d = y_cam * depth_values
    z_3d = depth_values

    # Flatten arrays
    x_flat = x_3d.flatten()
    y_flat = y_3d.flatten()
    z_flat = z_3d.flatten()

    # Get corresponding image colors
    image_colors = image[::step, ::step, :]
    colors_flat = image_colors.reshape(-1, 3)
    # Convert colors to Plotly-compatible rgb strings
    colors_rgb = [f'rgb({r},{g},{b})' for r, g, b in colors_flat]

    # Create 3D scatter plot with proper camera projection
    fig = go.Figure(data=[go.Scatter3d(
        x=x_flat,
        y=y_flat,
        z=z_flat,
        mode='markers',
        marker=dict(
            size=1.5,
            color=colors_rgb,
            opacity=0.9
        ),
        hovertemplate='<b>3D Position:</b> (%{x:.3f}, %{y:.3f}, %{z:.3f})<br>' +
                     '<b>Depth:</b> %{z:.2f}<br>' +
                     '<extra></extra>'
    )])

    fig.update_layout(
        title="3D Point Cloud Visualization (Camera Projection)",
        scene=dict(
            xaxis_title="X (meters)",
            yaxis_title="Y (meters)",
            zaxis_title="Z (meters)",
            camera=dict(
                eye=dict(x=2.0, y=2.0, z=2.0),
                center=dict(x=0, y=0, z=0),
                up=dict(x=0, y=0, z=1)
            ),
            aspectmode='data'
        ),
        width=700,
        height=600
    )

    return fig

def on_depth_submit(image, num_points, focal_x, focal_y):
    original_image = image.copy()

    h, w = image.shape[:2]

    # Predict depth using the model
    depth = predict_depth(image[:, :, ::-1])  # RGB to BGR if needed

    # Save raw 16-bit depth
    raw_depth = Image.fromarray(depth.astype('uint16'))
    tmp_raw_depth = tempfile.NamedTemporaryFile(suffix='.png', delete=False)
    raw_depth.save(tmp_raw_depth.name)

    # Normalize and convert to grayscale for display
    norm_depth = (depth - depth.min()) / (depth.max() - depth.min()) * 255.0
    norm_depth = norm_depth.astype(np.uint8)
    colored_depth = (matplotlib.colormaps.get_cmap('Spectral_r')(norm_depth)[:, :, :3] * 255).astype(np.uint8)

    gray_depth = Image.fromarray(norm_depth)
    tmp_gray_depth = tempfile.NamedTemporaryFile(suffix='.png', delete=False)
    gray_depth.save(tmp_gray_depth.name)

    # Create point cloud
    pcd = create_point_cloud(original_image, norm_depth, focal_x, focal_y, max_points=num_points)

    # Reconstruct mesh from point cloud
    mesh = reconstruct_surface_mesh_from_point_cloud(pcd)

    # Save mesh with faces as .ply
    tmp_pointcloud = tempfile.NamedTemporaryFile(suffix='.ply', delete=False)
    o3d.io.write_triangle_mesh(tmp_pointcloud.name, mesh)

    # Create enhanced 3D scatter plot visualization
    depth_3d = create_enhanced_3d_visualization(original_image, norm_depth, max_points=num_points)

    return [(original_image, colored_depth), tmp_gray_depth.name, tmp_raw_depth.name, tmp_pointcloud.name, depth_3d]

# --- Actual Wound Segmentation Functions ---
def create_automatic_wound_mask(image, method='deep_learning'):
    """
    Automatically generate wound mask from image using the actual deep learning model

    Args:
        image: Input image (numpy array)
        method: Segmentation method (currently only 'deep_learning' supported)

    Returns:
        mask: Binary wound mask
    """
    if image is None:
        return None

    # Use the actual deep learning model for segmentation
    if method == 'deep_learning':
        mask, _ = segmentation_model.segment_wound(image)
        return mask
    else:
        # Fallback to deep learning if method not recognized
        mask, _ = segmentation_model.segment_wound(image)
        return mask

def post_process_wound_mask(mask, min_area=100):
    """Post-process the wound mask to remove noise and small objects"""
    if mask is None:
        return None

    # Convert to binary if needed
    if mask.dtype != np.uint8:
        mask = mask.astype(np.uint8)

    # Apply morphological operations to clean up
    kernel = cv2.getStructuringElement(cv2.MORPH_ELLIPSE, (10, 10))
    mask = cv2.morphologyEx(mask, cv2.MORPH_CLOSE, kernel)
    mask = cv2.morphologyEx(mask, cv2.MORPH_OPEN, kernel)

    # Remove small objects using OpenCV
    contours, _ = cv2.findContours(mask, cv2.RETR_EXTERNAL, cv2.CHAIN_APPROX_SIMPLE)
    mask_clean = np.zeros_like(mask)

    for contour in contours:
        area = cv2.contourArea(contour)
        if area >= min_area:
            cv2.fillPoly(mask_clean, [contour], 255)

    # Fill holes
    mask_clean = cv2.morphologyEx(mask_clean, cv2.MORPH_CLOSE, kernel)

    return mask_clean

def analyze_wound_severity_auto(image, depth_map, pixel_spacing_mm=0.5, segmentation_method='deep_learning'):
    """Analyze wound severity with automatic mask generation using actual segmentation model"""
    if image is None or depth_map is None:
        return "❌ Please provide both image and depth map."

    # Generate automatic wound mask using the actual model
    auto_mask = create_automatic_wound_mask(image, method=segmentation_method)

    if auto_mask is None:
        return "❌ Failed to generate automatic wound mask. Please check if the segmentation model is loaded."

    # Post-process the mask
    processed_mask = post_process_wound_mask(auto_mask, min_area=500)

    if processed_mask is None or np.sum(processed_mask > 0) == 0:
        return "❌ No wound region detected by the segmentation model. Try uploading a different image or use manual mask."

    # Analyze severity using the automatic mask
    return analyze_wound_severity(image, depth_map, processed_mask, pixel_spacing_mm)

# --- Main Gradio Interface ---
with gr.Blocks(css=css, title="Wound Analysis System") as demo:
    gr.HTML("<h1>Wound Analysis System</h1>")
    #gr.Markdown("### Complete workflow: Classification → Depth Estimation → Wound Severity Analysis")

    # Shared states
    shared_image = gr.State()
    shared_depth_map = gr.State()

    with gr.Tabs():
        
        # Tab 1: Wound Classification
        with gr.Tab("1. 🔍 Wound Classification & Initial Analysis"):
            gr.Markdown("### Step 1: Classify wound type and get initial AI analysis")
            #gr.Markdown("Upload an image to identify the wound type and receive detailed analysis from our Vision AI.")
            

            with gr.Row():
                # Left Column - Image Upload
                with gr.Column(scale=1):
                    gr.HTML('<h2 style="text-align: left; color: #d97706; margin-top: 0; font-weight: bold; font-size: 1.8rem;">Upload Wound Image</h2>')
                    classification_image_input = gr.Image(
                        label="",
                        type="pil",
                        height=400
                    )
                    # Place Clear and Analyse buttons side by side
                    with gr.Row():
                        classify_clear_btn = gr.Button(
                            "Clear",
                            variant="secondary",
                            size="lg",
                            scale=1
                        )
                        analyse_btn = gr.Button(
                            "Analyse",
                            variant="primary",
                            size="lg",
                            scale=1
                        )
                # Right Column - Classification Results
                with gr.Column(scale=1):
                    gr.HTML('<h2 style="text-align: left; color: #d97706; margin-top: 0; font-weight: bold; font-size: 1.8rem;">Classification Results</h2>')
                    classification_output = gr.Label(
                        label="",
                        num_top_classes=5,
                        show_label=False
                    )

            # Second Row - Full Width AI Analysis
            with gr.Row():
                with gr.Column(scale=1):
                    gr.HTML('<h2 style="text-align: left; color: #d97706; margin-top: 2rem; margin-bottom: 1rem; font-weight: bold; font-size: 1.8rem;">Wound Visual Analysis</h2>')
                    gemini_output = gr.HTML(
                        value="""
                        <div style="
                            border-radius: 12px;
                            padding: 20px;
                            box-shadow: 0 4px 12px rgba(0,0,0,0.1);
                            font-family: Arial, sans-serif;
                            min-height: 200px;
                            display: flex;
                            align-items: center;
                            justify-content: center;
                            color: white;
                            width: 100%;
                            border-left: 4px solid #d97706;
                            font-weight: bold;
                        ">
                            Upload an image to get AI-powered wound analysis
                        </div>
                        """
                    )

            # Event handlers for classification tab
            classify_clear_btn.click(
                fn=lambda: (None, None, """
                    <div style="
                        border-radius: 12px;
                        padding: 20px;
                        box-shadow: 0 4px 12px rgba(0,0,0,0.1);
                        font-family: Arial, sans-serif;
                        min-height: 200px;
                        display: flex;
                        align-items: center;
                        justify-content: center;
                        color: white;
                        width: 100%;
                        border-left: 4px solid #d97706;
                        font-weight: bold;
                    ">
                        Upload an image to get AI-powered wound analysis
                    </div>
                """),
                inputs=None,
                outputs=[classification_image_input, classification_output, gemini_output]
            )

            # Only run classification on image upload
            def classify_and_store(image):
                result = classify_wound(image)
                return result

            classification_image_input.change(
                fn=classify_and_store,
                inputs=classification_image_input,
                outputs=classification_output
            )

            # Store image in shared state for next tabs
            def store_shared_image(image):
                return image

            classification_image_input.change(
                fn=store_shared_image,
                inputs=classification_image_input,
                outputs=shared_image
            )

            # Run Gemini analysis only when Analyse button is clicked
            def run_gemini_on_click(image, classification):
                # Get top label
                if isinstance(classification, dict) and classification:
                    top_label = max(classification.items(), key=lambda x: x[1])[0]
                else:
                    top_label = "Unknown"
                gemini_analysis = analyze_wound_with_gemini(image, top_label)
                formatted_analysis = format_gemini_analysis(gemini_analysis)
                return formatted_analysis

            analyse_btn.click(
                fn=run_gemini_on_click,
                inputs=[classification_image_input, classification_output],
                outputs=gemini_output
            )

        # Tab 2: Depth Estimation
        with gr.Tab("2. 📏 Depth Estimation & 3D Visualization"):
            gr.Markdown("### Step 2: Generate depth maps and 3D visualizations")
            gr.Markdown("This module creates depth maps and 3D point clouds from your images.")

            with gr.Row():
                load_from_classification_btn = gr.Button("🔄 Load Image from Classification Tab", variant="secondary")

            with gr.Row():
                depth_input_image = gr.Image(label="Input Image", type='numpy', elem_id='img-display-input')
                depth_image_slider = ImageSlider(label="Depth Map with Slider View", elem_id='img-display-output')

            with gr.Row():
                depth_submit = gr.Button(value="Compute Depth", variant="primary")

                points_slider = gr.Slider(minimum=1000, maximum=10000, value=10000, step=1000,
                                         label="Number of 3D points (upload image to update max)")

            with gr.Row():
                focal_length_x = gr.Slider(minimum=100, maximum=1000, value=470.4, step=10,
                                          label="Focal Length X (pixels)")
                focal_length_y = gr.Slider(minimum=100, maximum=1000, value=470.4, step=10,
                                          label="Focal Length Y (pixels)")

            # Reorganized layout: 2 columns - 3D visualization on left, file outputs stacked on right
            with gr.Row():
                with gr.Column(scale=2):
                    # 3D Visualization
                    gr.Markdown("### 3D Point Cloud Visualization")
                    gr.Markdown("Enhanced 3D visualization using proper camera projection. Hover over points to see 3D coordinates.")
                    depth_3d_plot = gr.Plot(label="3D Point Cloud")
                
                with gr.Column(scale=1):
                    gr.Markdown("### Download Files")
                    gray_depth_file = gr.File(label="Grayscale depth map", elem_id="download")
                    raw_file = gr.File(label="16-bit raw output (can be considered as disparity)", elem_id="download")
                    point_cloud_file = gr.File(label="Point Cloud (.ply)", elem_id="download")



        # Tab 3: Wound Severity Analysis
        with gr.Tab("3. 🩹 Wound Severity Analysis"):
            gr.Markdown("### Step 3: Analyze wound severity using depth maps")
            gr.Markdown("This module analyzes wound severity based on depth distribution and area measurements.")

            with gr.Row():
                # Load depth map from previous tab
                load_depth_btn = gr.Button("🔄 Load Depth Map from Tab 2", variant="secondary")

            with gr.Row():
                severity_input_image = gr.Image(label="Original Image", type='numpy')
                severity_depth_map = gr.Image(label="Depth Map (from Tab 2)", type='numpy')

            with gr.Row():
                wound_mask_input = gr.Image(label="Auto-Generated Wound Mask", type='numpy')
                
            with gr.Row():
                severity_output = gr.HTML(
                    label="🤖 AI-Powered Medical Assessment",
                    value="""
                    <div style='padding: 30px; background-color: #1e1e1e; border-radius: 12px; box-shadow: 0 0 10px rgba(0,0,0,0.5); text-align: center;'>
                        <div style='font-size: 24px; font-weight: bold; color: #ff9800; margin-bottom: 15px;'>
                            🩹 Wound Severity Analysis
                        </div>
                        <div style='font-size: 18px; color: #cccccc; margin-bottom: 20px;'>
                            ⏳ Waiting for Input...
                        </div>
                        <div style='color: #888888; font-size: 14px;'>
                            Please upload an image and depth map, then click "🤖 Analyze Severity with Auto-Generated Mask" to begin AI-powered medical assessment.
                        </div>
                    </div>
                    """
                )

            gr.Markdown("**Note:** The deep learning segmentation model will automatically generate a wound mask when you upload an image or load a depth map.")

            with gr.Row():
                auto_severity_button = gr.Button("🤖 Analyze Severity with Auto-Generated Mask", variant="primary", size="lg")
                pixel_spacing_slider = gr.Slider(minimum=0.1, maximum=2.0, value=0.5, step=0.1,
                                               label="Pixel Spacing (mm/pixel)")
                depth_calibration_slider = gr.Slider(minimum=5.0, maximum=30.0, value=15.0, step=1.0,
                                                   label="Depth Calibration (mm)", 
                                                   info="Adjust based on expected maximum wound depth")

            #gr.Markdown("**Pixel Spacing:** Adjust based on your camera calibration. Default is 0.5 mm/pixel.")
            #gr.Markdown("**Depth Calibration:** Adjust the maximum expected wound depth to improve measurement accuracy. For shallow wounds use 5-10mm, for deep wounds use 15-30mm.")

            #gr.Markdown("**Note:** When you load a depth map or upload an image, the segmentation model will automatically generate a wound mask.")

            # Update slider when image is uploaded
            depth_input_image.change(
                fn=update_slider_on_image_upload,
                inputs=[depth_input_image],
                outputs=[points_slider]
            )

            # Modified depth submit function to store depth map
            def on_depth_submit_with_state(image, num_points, focal_x, focal_y):
                results = on_depth_submit(image, num_points, focal_x, focal_y)
                # Extract depth map from results for severity analysis
                depth_map = None
                if image is not None:
                    depth = predict_depth(image[:, :, ::-1])  # RGB to BGR if needed
                    # Normalize depth for severity analysis
                    norm_depth = (depth - depth.min()) / (depth.max() - depth.min()) * 255.0
                    depth_map = norm_depth.astype(np.uint8)
                return results + [depth_map]

            depth_submit.click(on_depth_submit_with_state,
                             inputs=[depth_input_image, points_slider, focal_length_x, focal_length_y],
                             outputs=[depth_image_slider, gray_depth_file, raw_file, point_cloud_file, depth_3d_plot, shared_depth_map])

            # Function to load image from classification to depth tab
            def load_image_from_classification(shared_img):
                if shared_img is None:
                    return None, "❌ No image available from classification tab. Please upload an image in Tab 1 first."
                
                # Convert PIL image to numpy array for depth estimation
                if hasattr(shared_img, 'convert'):
                    # It's a PIL image, convert to numpy
                    img_array = np.array(shared_img)
                    return img_array, "✅ Image loaded from classification tab successfully!"
                else:
                    # Already numpy array
                    return shared_img, "✅ Image loaded from classification tab successfully!"
            
            # Connect the load button
            load_from_classification_btn.click(
                fn=load_image_from_classification,
                inputs=shared_image,
                outputs=[depth_input_image, gr.HTML()]
            )

            # Load depth map to severity tab and auto-generate mask
            def load_depth_to_severity(depth_map, original_image):
                if depth_map is None:
                    return None, None, None, "❌ No depth map available. Please compute depth in Tab 2 first."
                
                # Auto-generate wound mask using segmentation model
                if original_image is not None:
                    auto_mask, _ = segmentation_model.segment_wound(original_image)
                    if auto_mask is not None:
                        # Post-process the mask
                        processed_mask = post_process_wound_mask(auto_mask, min_area=500)
                        if processed_mask is not None and np.sum(processed_mask > 0) > 0:
                            return depth_map, original_image, processed_mask, "✅ Depth map loaded and wound mask auto-generated!"
                        else:
                            return depth_map, original_image, None, "✅ Depth map loaded but no wound detected. Try uploading a different image."
                    else:
                        return depth_map, original_image, None, "✅ Depth map loaded but segmentation failed. Try uploading a different image."
                else:
                    return depth_map, original_image, None, "✅ Depth map loaded successfully!"

            load_depth_btn.click(
                fn=load_depth_to_severity,
                inputs=[shared_depth_map, depth_input_image],
                outputs=[severity_depth_map, severity_input_image, wound_mask_input, gr.HTML()]
            )

            # Loading state function
            def show_loading_state():
                return """
                <div style='padding: 30px; background-color: #1e1e1e; border-radius: 12px; box-shadow: 0 0 10px rgba(0,0,0,0.5); text-align: center;'>
                    <div style='font-size: 24px; font-weight: bold; color: #ff9800; margin-bottom: 15px;'>
                        🩹 Wound Severity Analysis
                    </div>
                    <div style='font-size: 18px; color: #4CAF50; margin-bottom: 20px;'>
                        🔄 AI Analysis in Progress...
                    </div>
                    <div style='color: #cccccc; font-size: 14px; margin-bottom: 15px;'>
                        • Generating wound mask with deep learning model<br>
                        • Computing depth measurements and statistics<br>
                        • Analyzing wound characteristics with Gemini AI<br>
                        • Preparing comprehensive medical assessment
                    </div>
                    <div style='display: inline-block; width: 30px; height: 30px; border: 3px solid #f3f3f3; border-top: 3px solid #4CAF50; border-radius: 50%; animation: spin 1s linear infinite;'></div>
                    <style>
                        @keyframes spin {
                            0% { transform: rotate(0deg); }
                            100% { transform: rotate(360deg); }
                        }
                    </style>
                </div>
                """

            # Automatic severity analysis function
            def run_auto_severity_analysis(image, depth_map, pixel_spacing, depth_calibration):
                if depth_map is None:
                    return """
                    <div style='padding: 30px; background-color: #1e1e1e; border-radius: 12px; box-shadow: 0 0 10px rgba(0,0,0,0.5); text-align: center;'>
                        <div style='font-size: 24px; font-weight: bold; color: #f44336; margin-bottom: 15px;'>
                            ❌ Error
                        </div>
                        <div style='font-size: 16px; color: #cccccc;'>
                            Please load depth map from Tab 1 first.
                        </div>
                    </div>
                    """

                # Generate automatic wound mask using the actual model
                auto_mask = create_automatic_wound_mask(image, method='deep_learning')

                if auto_mask is None:
                    return """
                    <div style='padding: 30px; background-color: #1e1e1e; border-radius: 12px; box-shadow: 0 0 10px rgba(0,0,0,0.5); text-align: center;'>
                        <div style='font-size: 24px; font-weight: bold; color: #f44336; margin-bottom: 15px;'>
                            ❌ Error
                        </div>
                        <div style='font-size: 16px; color: #cccccc;'>
                            Failed to generate automatic wound mask. Please check if the segmentation model is loaded.
                        </div>
                    </div>
                    """

                # Post-process the mask with fixed minimum area
                processed_mask = post_process_wound_mask(auto_mask, min_area=500)

                if processed_mask is None or np.sum(processed_mask > 0) == 0:
                    return """
                    <div style='padding: 30px; background-color: #1e1e1e; border-radius: 12px; box-shadow: 0 0 10px rgba(0,0,0,0.5); text-align: center;'>
                        <div style='font-size: 24px; font-weight: bold; color: #ff9800; margin-bottom: 15px;'>
                            ⚠️ No Wound Detected
                        </div>
                        <div style='font-size: 16px; color: #cccccc;'>
                            No wound region detected by the segmentation model. Try uploading a different image or use manual mask.
                        </div>
                    </div>
                    """

                # Analyze severity using the automatic mask
                return analyze_wound_severity(image, depth_map, processed_mask, pixel_spacing, depth_calibration)

            # Connect event handler with loading state
            auto_severity_button.click(
                fn=show_loading_state,
                inputs=[],
                outputs=[severity_output]
            ).then(
                fn=run_auto_severity_analysis,
                inputs=[severity_input_image, severity_depth_map, pixel_spacing_slider, depth_calibration_slider],
                outputs=[severity_output]
            )



            # Auto-generate mask when image is uploaded
            def auto_generate_mask_on_image_upload(image):
                if image is None:
                    return None, "❌ No image uploaded."
                
                # Generate automatic wound mask using segmentation model
                auto_mask, _ = segmentation_model.segment_wound(image)
                if auto_mask is not None:
                    # Post-process the mask
                    processed_mask = post_process_wound_mask(auto_mask, min_area=500)
                    if processed_mask is not None and np.sum(processed_mask > 0) > 0:
                        return processed_mask, "✅ Wound mask auto-generated using deep learning model!"
                    else:
                        return None, "✅ Image uploaded but no wound detected. Try uploading a different image."
                else:
                    return None, "✅ Image uploaded but segmentation failed. Try uploading a different image."

            # Load shared image from classification tab
            def load_shared_image(shared_img):
                if shared_img is None:
                    return gr.Image(), "❌ No image available from classification tab"

                # Convert PIL image to numpy array for depth estimation
                if hasattr(shared_img, 'convert'):
                    # It's a PIL image, convert to numpy
                    img_array = np.array(shared_img)
                    return img_array, "✅ Image loaded from classification tab"
                else:
                    # Already numpy array
                    return shared_img, "✅ Image loaded from classification tab"

            # Auto-generate mask when image is uploaded to severity tab
            severity_input_image.change(
                fn=auto_generate_mask_on_image_upload,
                inputs=[severity_input_image],
                outputs=[wound_mask_input, gr.HTML()]
            )



if __name__ == '__main__':
    demo.queue().launch(
        server_name="0.0.0.0",
        server_port=7860,
        share=True
    )