STING dimerization was also substantially reduced in cells
Furthermore , the level of ubiquitinated forms of STING , RIG - I , TBK1 and IRF-3 are reduced in cells
STING dimerization was also substantially reduced in cells infected with SARS - CoV.
Furthermore , the level of ubiquitinated forms of STING , RIG - I , TBK1 and IRF-3 are reduced in cells expressing wild type or catalytic mutants of PLP2-TM , likely contributing to disruption of signaling required for IFN induction .