TREM2 variants have been identified as risk factors for Alzheimer 's disease ( AD ) and other neurodegenerative diseases ( NDDs ) .
These TREM2 variants also confer the highest risk
TREM2 variants have been identified as risk factors for Alzheimer 's disease ( AD ) and other neurodegenerative diseases ( NDDs ) .
These TREM2 variants also confer the highest risk for developing Alzheimer 's disease of any risk factor identified in nearly two decades , suggesting that understanding more about TREM2 function could provide key insights into NDD pathology and provide avenues for novel immune - related NDD biomarkers and therapeutics .