we utilized a virtual screening technique
the compounds NSC345647 , NSC87511 , and NSC343256 showed better EC 50 values than the broad - spectrum antiviral drug ribavirin and the protease inhibitor lopinavir , under all the test conditions
To find small molecules with anti - feline infectious peritonitis virus ( FIPV ) properties , we utilized a virtual screening technique to identify the active site on the viral protease for the binding of the available natural compounds .
As determined by the cell - based assay , the compounds NSC345647 , NSC87511 , and NSC343256 showed better EC 50 values than the broad - spectrum antiviral drug ribavirin and the protease inhibitor lopinavir , under all the test conditions including pre - viral entry , post - viral entry , and prophylactic activity .