that the energy regulator AMPK , <*> restricts infection of the Bunyavirus , Rift Valley Fever Virus ( RVFV ) , an important re - emerging arthropod - borne human pathogen
that AMPK is activated during RVFV infection ,
We found that the energy regulator AMPK , which potently inhibits fatty acid synthesis , restricts infection of the Bunyavirus , Rift Valley Fever Virus ( RVFV ) , an important re - emerging arthropod - borne human pathogen for which there are no effective vaccines or therapeutics .
Furthermore , we found that AMPK is activated during RVFV infection , leading to the phosphorylation and inhibition of acetyl - CoA carboxylase , the first rate - limiting enzyme in fatty acid synthesis .