In this study , we identified fexaramine as a potent inhibitor of FCV
A fexaramine resistant FCV mutant has a single amino acid change in the P2 domain of VP1 ( the major capsid ) ,
In this study , we identified fexaramine as a potent inhibitor of FCV including vs - FCV strains in cell culture and demonstrated that fexaramine is a entry blocker for FCV by using various experiments including time - of - addition studies , generation of resistant viruses in cell culture and the reverse genetics system .
A fexaramine resistant FCV mutant has a single amino acid change in the P2 domain of VP1 ( the major capsid ) , and the importance of this mutation for conferring resistance was confirmed using the reverse genetics system .