that this pathway plays a broad role in antiviral defense
Therefore , AMPK is an important component of the cell intrinsic immune response
Lastly , we found that this pathway plays a broad role in antiviral defense since additional viruses from disparate families were also restricted by AMPK and LKB1 .
Therefore , AMPK is an important component of the cell intrinsic immune response that restricts infection through a novel mechanism involving the inhibition of fatty acid metabolism .