and the inclusion of adjuvants and/or the use of vaccine delivery systems is almost always needed .
Among vaccine delivery systems , micro - and nanoparticulated ones are attractive ,
However , they generate a weaker immune response than other vaccines , and the inclusion of adjuvants and/or the use of vaccine delivery systems is almost always needed .
Among vaccine delivery systems , micro - and nanoparticulated ones are attractive , because their particulate nature can increase cross - presentation of the peptide .