It is well established that increasing age is associated with a decreased capacity of the immune system
much of what we have learned is owed to the utility of experimental mouse models of aging .
It is well established that increasing age is associated with a decreased capacity of the immune system to mediate effective immune responses to vaccination and invading pathogens .
Because of the inherent limitations of conducting experiments in humans , much of what we have learned is owed to the utility of experimental mouse models of aging .