TREM2 variants have been identified as risk factors for Alzheimer 's disease ( AD ) and other neurodegenerative diseases ( NDDs ) .
We provide a comprehensive review of our current understanding of TREM2 biology ,
TREM2 variants have been identified as risk factors for Alzheimer 's disease ( AD ) and other neurodegenerative diseases ( NDDs ) .
We provide a comprehensive review of our current understanding of TREM2 biology , including new insights into the regulation of TREM2 expression , and TREM2 signaling and function across NDDs .