that expression of the membrane anchored PLP domain from human HCoV - NL63 ( PLP2-TM ) or SARS - CoV ( PLpro - TM ) inhibits STING - mediated activation of IRF-3 nuclear translocation and induction of IRF-3 dependent promoters .
Both catalytically active and inactive forms of CoV PLPs co - immunoprecipitated with STING ,
We found that expression of the membrane anchored PLP domain from human HCoV - NL63 ( PLP2-TM ) or SARS - CoV ( PLpro - TM ) inhibits STING - mediated activation of IRF-3 nuclear translocation and induction of IRF-3 dependent promoters .
Both catalytically active and inactive forms of CoV PLPs co - immunoprecipitated with STING , and viral replicase proteins co - localize with STING in HCoV - NL63-infected cells .