that AMPK is activated during RVFV infection ,
that this pathway plays a broad role in antiviral defense
Furthermore , we found that AMPK is activated during RVFV infection , leading to the phosphorylation and inhibition of acetyl - CoA carboxylase , the first rate - limiting enzyme in fatty acid synthesis .
Lastly , we found that this pathway plays a broad role in antiviral defense since additional viruses from disparate families were also restricted by AMPK and LKB1 .