whereas the infectious entry of DENV-2 in the same cell system was independent of clathrin .
Treatment with the inhibitors nystatin and methyl - b - cyclodextrin , as well as transfection of Vero cells with dominant negative caveolin-1 , had no effect on DENV-2 virus infection .
By treatment with dansylcadaverine and chlorpromazine and overexpression of a dominant negative form of the Eps15 protein , a clathrin - mediated endocytosis for productive DENV-1 internalization into Vero cells was demonstrated whereas the infectious entry of DENV-2 in the same cell system was independent of clathrin .
Treatment with the inhibitors nystatin and methyl - b - cyclodextrin , as well as transfection of Vero cells with dominant negative caveolin-1 , had no effect on DENV-2 virus infection .