Ectopic expression of catalytically active PLP2-TM blocks STING dimer formation
STING dimerization was also substantially reduced in cells
Ectopic expression of catalytically active PLP2-TM blocks STING dimer formation and negatively regulates assembly of STING - MAVS - TBK1 / IKKe complexes required for activation of IRF-3 .
STING dimerization was also substantially reduced in cells infected with SARS - CoV.