it is now clear that this is true in vitro ,
Likewise , <*> more than half of published studies demonstrate a pro - inflammatory role for TREM2 ,
While it is still often cited that TREM2 expression is decreased by pro - inflammatory stimuli , it is now clear that this is true in vitro , but inflammatory stimuli in vivo almost universally increase TREM2 expression .
Likewise , while TREM2 function is classically described as promoting an anti - inflammatory phenotype , more than half of published studies demonstrate a pro - inflammatory role for TREM2 , suggesting that its role in inflammation is much more complex .