The modifications led to the identification of several potent derivatives ,
Compound 5h , in particular , displayed the most potent inhibitory activity , with a K i value of 0.006 mM.
The modifications led to the identification of several potent derivatives , including 5cek and 5n with the inhibitory activities ( K i or IC 50 ) in the submicromolar to nanomolar range .
Compound 5h , in particular , displayed the most potent inhibitory activity , with a K i value of 0.006 mM.