We quantitatively examined the relationship between PERC toxicokinetics and toxicodynamics at the population level
Male mice from 45 strains of the Collaborative Cross ( CC ) were orally administered a single dose of PERC <*> or vehicle
We quantitatively examined the relationship between PERC toxicokinetics and toxicodynamics at the population level to test whether individuals with increased oxidative metabolism are be more sensitive to hepatotoxicity following PERC exposure .
Male mice from 45 strains of the Collaborative Cross ( CC ) were orally administered a single dose of PERC ( 1,000 mg / kg ) or vehicle ( Alkamuls - EL620 ) and euthanized at various time points ( n = 1 = strain = time ) .