The degree of illness <*> is directly related to the extent of provoked inflammation ,
Thus , risk factors for CLI can modulate either the vURTI risk <*> or the CLI risk given a vURTI
The degree of illness occurring during a vURTI is directly related to the extent of provoked inflammation , which in turn depends on the engagement of antiviral defense systems .
Thus , risk factors for CLI can modulate either the vURTI risk by affecting virus exposure and/or susceptibility to infection , or the CLI risk given a vURTI by affecting immunocompetence , the provoked inflammation and/or the interpretation of illness as a CLI .