The type II transmembrane serine proteases TMPRSS2 and HAT activate influenza viruses and the SARS - coronavirus ( TMPRSS2 ) in cell culture
that both HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids , the major receptor determinant of human influenza viruses , throughout the human respiratory tract .
The type II transmembrane serine proteases TMPRSS2 and HAT activate influenza viruses and the SARS - coronavirus ( TMPRSS2 ) in cell culture and may play an important role in viral spread and pathogenesis in the infected host .
Here , we show that both HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids , the major receptor determinant of human influenza viruses , throughout the human respiratory tract .