Viruses have evolved elaborate mechanisms
that human coronavirus ( HCoV ) NL63 and severe acute respiratory syndrome ( SARS ) CoV papain - like proteases ( PLP ) antagonize innate immune signaling
Viruses have evolved elaborate mechanisms to evade or inactivate the complex system of sensors and signaling molecules that make up the host innate immune response .
Here we show that human coronavirus ( HCoV ) NL63 and severe acute respiratory syndrome ( SARS ) CoV papain - like proteases ( PLP ) antagonize innate immune signaling mediated by STING ( stimulator of interferon genes , also known as MITA / ERIS / MYPS ) .