The entry of two dengue virus ( DENV ) serotypes into Vero cells was analysed
Our results conclusively show , for the first time , a differential mode of infective entry for DENV-1 and DENV-2 into a common host cell , Vero cells , as well as alternative entry pathways for a given serotype , DENV-2 , into different types of cells .
The entry of two dengue virus ( DENV ) serotypes into Vero cells was analysed using biochemical inhibitors , dominant negative mutants of cellular proteins involved in endocytic pathways , fluorescence microscopy and infectivity determinations .
Our results conclusively show , for the first time , a differential mode of infective entry for DENV-1 and DENV-2 into a common host cell , Vero cells , as well as alternative entry pathways for a given serotype , DENV-2 , into different types of cells .