that 3a misexpression induces apoptosis ,
From a forward genetic screen , 78 dominant 3a modifying loci were recovered
We further found that 3a misexpression induces apoptosis , which could be modulated by cellular cytochrome c levels and caspase activity .
From a forward genetic screen , 78 dominant 3a modifying loci were recovered and the identity of these modifiers revealed that the severity of the 3a - induced rough eye phenotype depends on multiple cellular processes including gene transcriptional regulation .