that human coronavirus ( HCoV ) NL63 and severe acute respiratory syndrome ( SARS ) CoV papain - like proteases ( PLP ) antagonize innate immune signaling
These results describe a new mechanism
Here we show that human coronavirus ( HCoV ) NL63 and severe acute respiratory syndrome ( SARS ) CoV papain - like proteases ( PLP ) antagonize innate immune signaling mediated by STING ( stimulator of interferon genes , also known as MITA / ERIS / MYPS ) .
These results describe a new mechanism used by CoVs in which CoV PLPs negatively regulate antiviral defenses by disrupting the STING - mediated IFN induction .