that human coronavirus ( HCoV ) NL63 and severe acute respiratory syndrome ( SARS ) CoV papain - like proteases ( PLP ) antagonize innate immune signaling
STING resides in the endoplasmic reticulum
Here we show that human coronavirus ( HCoV ) NL63 and severe acute respiratory syndrome ( SARS ) CoV papain - like proteases ( PLP ) antagonize innate immune signaling mediated by STING ( stimulator of interferon genes , also known as MITA / ERIS / MYPS ) .
STING resides in the endoplasmic reticulum and upon activation , forms dimers which assemble with MAVS , TBK-1 and IKKe , leading to IRF-3 activation and subsequent induction of interferon ( IFN ) .