that human coronavirus ( HCoV ) NL63 and severe acute respiratory syndrome ( SARS ) CoV papain - like proteases ( PLP ) antagonize innate immune signaling
that expression of the membrane anchored PLP domain from human HCoV - NL63 ( PLP2-TM ) or SARS - CoV ( PLpro - TM ) inhibits STING - mediated activation of IRF-3 nuclear translocation and induction of IRF-3 dependent promoters .
Here we show that human coronavirus ( HCoV ) NL63 and severe acute respiratory syndrome ( SARS ) CoV papain - like proteases ( PLP ) antagonize innate immune signaling mediated by STING ( stimulator of interferon genes , also known as MITA / ERIS / MYPS ) .
We found that expression of the membrane anchored PLP domain from human HCoV - NL63 ( PLP2-TM ) or SARS - CoV ( PLpro - TM ) inhibits STING - mediated activation of IRF-3 nuclear translocation and induction of IRF-3 dependent promoters .