A docking study <*> suggested the modification of a structurally flexible P3 N-(3methoxyphenyl)glycine with various rigid P3 moieties in 4 .
The modifications led to the identification of several potent derivatives ,
A docking study involving binding between the dipeptidic lead compound 4 and 3CL pro suggested the modification of a structurally flexible P3 N-(3methoxyphenyl)glycine with various rigid P3 moieties in 4 .
The modifications led to the identification of several potent derivatives , including 5cek and 5n with the inhibitory activities ( K i or IC 50 ) in the submicromolar to nanomolar range .