Both catalytically active and inactive forms of CoV PLPs co - immunoprecipitated with STING ,
Ectopic expression of catalytically active PLP2-TM blocks STING dimer formation
Both catalytically active and inactive forms of CoV PLPs co - immunoprecipitated with STING , and viral replicase proteins co - localize with STING in HCoV - NL63-infected cells .
Ectopic expression of catalytically active PLP2-TM blocks STING dimer formation and negatively regulates assembly of STING - MAVS - TBK1 / IKKe complexes required for activation of IRF-3 .