The great majority of the compounds part of this library have shown in vivo activity in animal models ,
This , in turn , is supported by the fact
The great majority of the compounds part of this library have shown in vivo activity in animal models , which is an indication that they possess overall favorable bioavailability properties and , hence , adequate pharmacokinetic profiles .
This , in turn , is supported by the fact that approximately 85 % of the compounds are compliant with Lipinski 's rule of five and ca .