QuestionSBA
QuestionChoice
This is incorrect. While some DOACs, specifically the direct thrombin inhibitors, can inhibit Factor IX, the primary target of most DOACs is Factor Xa.
10026128
d
Factor IX
QuestionChoice
This is incorrect. Factor VIII is involved in the intrinsic pathway of coagulation, while DOACs primarily target the common pathway by inhibiting Factor Xa or thrombin (Factor IIa).
10026126
b
Factor VIII
QuestionChoice
This is incorrect. Factor XIII is involved in the final stabilization of fibrin clots and is not a direct target of DOACs.
10026129
e
Factor XIII
QuestionChoice
This is incorrect. Factor VIIa is part of the extrinsic pathway and is not directly inhibited by DOACs.
10026127
c
Factor VIIa
QuestionChoice
This is correct. Most DOACs, such as apixaban, rivaroxaban, and edoxaban, primarily inhibit Factor Xa. This is a key factor in the common pathway of the coagulation cascade. By inhibiting Factor Xa, these medications reduce the formation of thrombin, which is essential for blood clot formation.
10026125
a
Factor Xa
Concept
Chapter
2693
4479
Direct oral anticoagulants
Topic
203
Pharmacology of Haemostasis and Thrombosis
17623
A 42 year old woman presents to the emergency department complaining of pain and swelling in her right calf. On questioning, she states that she recently returned from visiting family in Australia and takes the combined oral contraceptive pill. On examination, the right calf is 4cm larger than the left and is visibly red. The right calf is also extremely tender to touch.

An ultrasound scan confirms the presence of a deep vein thrombosis (DVT) and she is given a direct oral anticoagulant (DOAC).

Which of the following clotting factors is primarily inhibited by DOACs?
a