QuestionSBA
QuestionChoice
No, this is not the correct mechanism of action. Statins such as atorvastatin inhibit the HMG-CoA reductase enzyme, thus reducing serum cholesterol levels.
10007889
e
Sequesters bile acids within the gastrointestinal tract
QuestionChoice
No, this is not the correct mechanism of action. Statins such as atorvastatin inhibit the HMG-CoA reductase enzyme, thus reducing serum cholesterol levels.
10007888
d
Increased activation of lipoprotein lipase
QuestionChoice
Yes, this is the correct mechanism of action. Statins such as atorvastatin inhibit the HMG-CoA reductase enzyme, which usually drives cholesterol synthesis in the liver. Blocking this enzyme, therefore, helps to reduce serum cholesterol levels, and is an important part of the secondary prevention management following a myocardial infarction.
10007885
a
Inhibition of HMG-CoA reductase
QuestionChoice
No, this is not the correct mechanism of action. Statins such as atorvastatin inhibit the HMG-CoA reductase enzyme, thus reducing serum cholesterol levels.
10007886
b
Allosteric activation of HMG-CoA reductase
QuestionChoice
No, this is not the correct mechanism of action. Statins such as atorvastatin inhibit the HMG-CoA reductase enzyme, thus reducing serum cholesterol levels.
10007887
c
Inhibition of lyase enzyme
Concept
Chapter
2693
4628
Hypercholesterolaemia
Topic
162
General practice
14124
A 67-year-old man visits the GP for a check-up after a recent hospital admission for an ST-segment elevation myocardial infarction (STEMI). On examination, there is evidence of xanthelasma, tendon xanthoma, and a corneal arcus. A set of investigations are requested: **Total serum cholesterol**: 12 mmol/L (3.5-6.5 mmol/L) **Serum Triacylglycerol**: 2.9 mmol/L (0.7-2.0 mmol/L) **Serum lipid profile**: Increased amount of LDL The patient was commenced on atorvastatin during his hospital admission, but has not continued taking it as he does not understand its purpose.

Which answer option best describes the mechanism of action of atorvastatin?
a