QuestionSBA
QuestionChoice
This is incorrect. Cholecystokinin is a peptide hormone released in the duodenum that stimulates the release of digestive enzymes from the gallbladder and pancreas.
10027567
b
Cholecystokinin
QuestionChoice
This is incorrect. Secretin is released into the intestinal lumen in response to low duodenal pH.
10027568
c
Secretin
QuestionChoice
This is incorrect. Gastrin is a peptide hormone that stimulates the secretion of hydrochloric acid in the stomach.
10027569
d
Gastrin
QuestionChoice
This is incorrect. This inhibits pancreatic secretion stimulated by cholecystokinin by relaxing the gallbladder. It also stimulates gastric acid secretion.
10027570
e
Pancreatic polypeptide
QuestionChoice
This is correct. Pernicious anaemia is caused by a lack of vitamin B12. It is caused by autoimmune destruction of gastric parietal cells that are responsible for producing intrinsic factor, a protein necessary for vitamin B12 absorption. Patients may present with symptoms of anaemia such as fatigue and pallor, along with neurological deficits such as paraesthesia and loss of sensation. The patient's past medical history of type 1 diabetes is a risk factor for pernicious anaemia.
10027566
a
Intrinsic Factor
Concept
Chapter
2693
5682
Intrinsic factor
Topic
149
Gastro-intestinal physiology
17911
A 29 year old female attends her GP surgery. She has been struggling with fatigue for the last 3 months, despite sleeping for at least 9 hours a day. It makes it difficult to concentrate at work. She also reports pins and needles in her lower limbs. She has a past medical history of type 1 diabetes.

Blood tests show a macrocytic anaemia and vitamin B12 deficiency.

Which of the following proteins in the gastrointestinal tract are essential for the absorption of vitamin B12?
a