QuestionSBA
QuestionChoice
HLA-DR4 is not associated with anti-GBM disease. It is associated with conditions such as rheumatoid arthritis, felty's syndrome and multiple sclerosis.
10006894
d
HLA-DR4
QuestionChoice
ANCA (anti-neutrophil cytoplasmic antibodies) is associated with a number of medical conditions including microscopic polyangiitis, Wegener's granulomatosis, Churg-Strauss syndrome, and drug-induced vasculitis. It would not be raised in anti-GBM disease.
10006893
c
ANCA-positive
QuestionChoice
HLA-B27 is a blood test used to look for a protein present on white blood cells. It is associated with a number of conditions including ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and uveitis among others. It would not be raised as a result of anti-GBM disease.
10006892
b
HLA-B27
QuestionChoice
Anti-TPO (anti-thyroperoxidase) antibodies are raised in Hashimoto's thyroiditis - an autoimmune thyroid condition which leads to hypothyroidism.
10006895
e
Anti-TPO antibodies
QuestionChoice
This patient has anti-glomerular basement membrane disease, or Goodpasture's syndrome. This disease is a small-vessel vasculitis involving antibodies directed against antigens found on the glomerular basement membrane in the kidneys and lungs (anti-GBM). It is associated with pulmonary haemorrhage and rapidly progressive glomerulonephritis, and rapid treatment with plasmapheresis and steroids are needed to minimise long-term renal damage. Renal biopsy may show IgG deposits along the glomerular basement membrane, and a raised transfer factor may be present secondary to pulmonary haemorrhages. Although a minority of patients may be ANCA-positive, anti-GBM antibodies are much more likely to be seen.
10006891
a
Anti-GBM antibodies
Concept
Chapter
2693
4549
Anti-glomerular basement membrane disease
Topic
142
Nephrology
13925
A 32-year-old male presents with haemoptysis and worsening shortness of breath which started yesterday. He has been feeling more tired and weak than usual over the past week. A urine dipstick reveals microhaematuria and proteinuria. Blood tests show anaemia, with raised urea and creatinine demonstrating an acute kidney injury.

Based on the likely diagnosis, which of the following is most likely to be seen on blood tests?
a