QuestionSBA
QuestionChoice
Gliclazide is usually taken life-long
34086
b
Gliclazide can only be used for short-term treatment to prevent long-term side effects
QuestionChoice
Gliclazide is a sulfonylurea that increases the amount of insulin produced by the body
34087
c
Gliclazide is a biguanide that decreases glucose production by liver
QuestionChoice
If a dose of gliclazide is missed, patients are advised to take the next dose at the usual time. Patients should not take a double dose to make up for the forgotten dose
34088
d
If he has forgotten to take gliclazide the day before, he should take a double dose to make up for the forgotten dose
QuestionChoice
Gliclazide can cause weight gain by increasing the concentration of insulin, which is an anabolic hormone that promotes fat storage
34089
e
Gliclazide may cause weight loss
QuestionChoice
Gliclazide can sometimes lead to hypoglycaemia due to the increase in insulin synthesis. Hence, patients are advised to avoid missing meals and to carry a source of sugar with them at all times
34085
a
He should avoid missing meals to prevent low blood sugar from happening
Concept
Chapter
#### Monitoring

The BNF advises to monitor lung function (in patients with a history of obstructive airway disease).

#### Overdoses

Overdosages with beta-blockers may cause cardiac effects such as bradycardia, hypotension, syncope, conduction abnormalities, and heart failure. Bradycardia is the most common arrhythmia, but some beta-blockers may induce ventricular tachyarrhythmias secondary to prolongation of QT interval (e.g. sotalol) or QRS duration (e.g. propranolol).
Non-cardiovascular effects include central nervous system effects (including drowsiness, confusion, convulsions, hallucinations, and in severe cases coma), respiratory depression, and bronchospasm.

Management
 - Airway protection 
 - Activated charcoal within 1 hour
 - IV Fluids
 
IV glucagon is the first-line management.
 
For symptomatic bradycardia, IV atropine may be used.

2618
2761
Gliclazide
Topic
9
Internal Medicine
6828
Case presentation: A 55-year-old man attends the diabetes clinic for review of his diabetic medication. He still complains of thirst and frequent urination despite the up-titration of his metformin dose 3 months ago.  

PMH: Type 2 Diabetes Mellitus, Hypertension
DH: Metformin hydrochloride 1g PO BD, Captopril 50mg PO BD
Investigations: HbA1c 65 mmol/mol (20-42)
The patient is advised to add a new prescription of gliclazide 40mg PO daily to his current treatment regime.

Question: Select the most important information that should be provided for this patient.
a