QuestionSBA
QuestionChoice
Yes, this is the correct answer. Prolyl Hydroxylase is responsible for the hydroxylation of proline and lysine amino acid residues on tropocollagen. This causes the stabilisation of the triple helix of collagen by forming hydrogen bonds between the tropocollagen units. A deficiency of vitamin C results in poor activity of prolyl hydroxylase and hence poor hydroxylation of proline and lysine residues, leading to less stabilisation of the tropocollagen triple helix. This leads to weak collagen fibres resulting in symptoms such as bruising, hair loss and gum disease.
10007990
a
Prolyl Hydroxylase
QuestionChoice
No, this is not the correct answer. This enzyme is used to break down collagen. It does not depend upon vitamin C in order to function.
10007994
e
Collagenase
QuestionChoice
No, this is not the correct answer. Acetylcholinesterase enzymes at found at postsynaptic neuromuscular junctions, and work by breaking down acetylcholine. They do not depend upon vitamin C in order to function.
10007991
b
Acetylcholinesterase
QuestionChoice
No, this is not the correct answer. This enzyme is responsible for the cleavage of N and C-terminal peptides of the procollagen molecules in order to form tropocollagen molecules. It does not depend upon vitamin C in order to function.
10007992
c
Procollagen peptidase
QuestionChoice
No, this is not the correct answer. This enzyme is responsible for the cleavage of the signal peptide of preprocollagen to form procollagen. It does not depend upon vitamin C in order to function.
10007993
d
Signal peptidase
Concept
Chapter
2693
4594
Scurvy
Topic
180
Biochemistry
14145
A 32-year-old man presents to the GP with easy bruising of the skin, hair loss, and severe gum disease. He has a busy job as a medical registrar, where he is often unable to find time to buy fresh fruit and vegetables. He is diagnosed with vitamin C deficiency, also known as scurvy.

Which of the following enzymes is most likely to be affected by vitamin C deficiency?
a