QuestionSBA
QuestionChoice
Whilst ANA can be used to assist in the diagnosis of lupus, it has a high sensitivity, rather than a high specificity.
10002393
b
Anti-nuclear antibody (ANA)
QuestionChoice
This patient is presenting with signs and symptoms characteristic of systemic lupus erythematosus (SLE), given the generalised systemic symptoms and the presence of a butterfly rash. One of the most specific investigations for SLE is the anti-dsDNA test which can be used to help confirm the diagnosis.
10002392
a
Anti-double-stranded DNA (anti-dsDNA)
QuestionChoice
ESR may be used as an inflammatory marker to monitor the progression of lupus. However, it is not used as a specific investigation to confirm the initial diagnosis.
10002396
e
Erythrocyte sedimentation rate (ESR)
QuestionChoice
Whilst rheumatoid factor may be positive in lupus, it is not a very specific investigation for the condition.
10002394
c
Rheumatoid factor
QuestionChoice
Anti-CCP is a specific investigation for the diagnosis of rheumatoid arthritis, as opposed to lupus.
10002395
d
Anti-cyclic citrullinated peptide (anti-CCP)
Concept
Chapter
2693
4036
Systemic lupus erythematosus (SLE)
Topic
146
Rheumatology
13025
A 30-year-old female presents with generalised fatigue, recurrent mouth ulcers and joint pains. On examination, she is noted to have a red rash on her face which spares the nasolabial folds.

Which of the following investigations is most specific at confirming the most likely diagnosis?
a