QuestionSBA
QuestionChoice
This is the correct answer. Two consecutive GABA-mediated inhibitory signals (from the corpus striatum and internal globus pallidus) result in disinhibition of the VA/VL complex in the thalamus.
10007316
a
GABA
QuestionChoice
This answer is incorrect. Glutamate is an excitatory neurotransmitter. In the direct basal ganglia pathway, glutamatergic neurons are responsible for excitatory input into the corpus striatum from the cerebral cortex.
10007318
c
Glutamate
QuestionChoice
This answer is incorrect. In the direct basal ganglia pathway, there is excitatory dopaminergic input from the substantia nigra pars compacta to the corpus striatum. This is not involved in disinhibition, where there are two consecutive inhibitory signals.
10007317
b
Dopamine
QuestionChoice
This answer is incorrect. Serotonin is not a key neurotransmitter involved in the direct basal ganglia pathway.
10007319
d
Serotonin
QuestionChoice
This answer is incorrect. Noradrenaline is not a key neurotransmitter involved in the direct basal ganglia pathway.
10007320
e
Noradrenaline
Concept
Chapter
2693
3823
Basal ganglia circuits
Topic
152
Neuroscience
14010
A 65-year-old man with a three-month history of asymmetrical tremors and bradykinesia is diagnosed with Parkinson's Disease.

In the direct pathway in the basal ganglia, which of the following inhibitory neurotransmitters is responsible for the disinhibition of the ventroanterior/ventrothalamic (VA/VL) complex in the thalamus?
a