QuestionSBA
QuestionChoice
Metoclopramide stimulates inhibitory nitrergic neurons which results in coordinated gastric motility.
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d
Metoclopramide inhibits inhibitory nitrergic neurons
QuestionChoice
Metoclopramide increases lower oesophageal sphincter and gastric tone to increase intragastric pressure. This helps to stimulate gastric motility and accelerate gastric emptying.
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c
It decreases intragastric pressure
QuestionChoice
Metoclopramide **inhibits** D2 receptors. This increases the release of acetylcholine which increases lower oesophageal sphincter tone and gastric contractions.
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b
It stimulates presynaptic and postsynaptic D2 receptors which promotes the release of acetylcholine from intrinsic myenteric cholinergic neurons
QuestionChoice
Metoclopramide inhibits 5-HT3 receptors.
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e
It stimulates 5-HT3 receptors
QuestionChoice
Inhibition of D2 receptors by metoclopramide increases the release of acetylcholine. Acetylcholine acts on the parasympathetic nervous system to increase digestion and excretion.
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a
It stimulates the release of acetylcholine which increases peristalsis of the small intestine
Concept
Chapter
2693
5763
Gastroparesis
Topic
136
Gastroenterology
17251
A 55-year-old male presents with abdominal pain and bloating. After several tests are conducted, he is diagnosed with gastroparesis and given metoclopramide for symptomatic relief.

How does metoclopramide promote gastric motility and emptying?
a