QuestionSBA
QuestionChoice
Ondansetron is an anti-emetic. It works by blocking 5HT-3 receptors in the gastrointestinal tract and the CNS. It does not affect gout.
10023638
d
Ondansetron
QuestionChoice
Losartan is an angiotensin II receptor blocker which affects the RAAS system and blood pressure. It decreases the risk of gout as it causes a decrease in uric acid levels within the blood.
10023636
b
Losartan
QuestionChoice
Tazocin is an antibiotic comprising of piperacillin and tazobactam. It has no role in gout, only in treating bacterial infections.
10023639
e
Tazocin
QuestionChoice
Bendroflumethiazide is a thiazide diuretic that can also directly increase uric acid re-absorption in the proximal renal tubules, which can cause hyperuricaemia. As gout is due to a build-up of urate crystals in a joint, having a higher concentration of uric acid in the blood will increase the likelihood of a flare-up.
10023635
a
Bendroflumethiazide
QuestionChoice
Allopurinol is a gout treatment, so would not cause a flare-up of this patient's gout. Allopurinol blocks the effects of xanthine oxidase - the protein that converts hypoxanthine to uric acid - reducing the level of uric acid within the body.
10023637
c
Allopurinol
Concept
Chapter
2693
3815
Thiazide diuretics
Topic
169
Cardiovascular pharmacology
17125
A 63-year-old male with a history of gout presents to the GP with a hot, swollen first metatarsophalangeal joint (big toe joint). The GP suspects another flare-up of gout and thinks it may be due to some of his medications.

Which of the following medications could precipitate his gout?
a