QuestionSBA
QuestionChoice
IL-6 is a pro-inflammatory cytokine which has numerous functions; one of them being to act on the hypothalamus to increase the body's temperature. It also causes the stimulation of bone marrow to produce leukocytes.
10023470
a
IL-6 on the hypothalamus
QuestionChoice
IL-6 is a molecule which affects the temperature of the body but it does not act on prostaglandin synthesis, this is the way that COX-inhibitors (such as aspirin) work.
10023471
b
IL-6 preventing prostaglandin synthesis
QuestionChoice
IL-4 stimulates B and T cell proliferation, which does happen in the bone marrow. It plays no role in increasing the body's temperature.
10023474
e
IL-4 on the bone marrow
QuestionChoice
IL-3 does not cause fever and does not act on the hypothalamus. IL-3 is used to regulate haematopoiesis.
10023473
d
IL-3 on the hypothalamus
QuestionChoice
TNF-alpha does increase the body's temperature, however, it does not do this by acting on the skin. It does it by acting on the hypothalamus, liver and bone marrow.
10023472
c
TNF-alpha on the skin
Concept
Chapter
2693
5679
Inflammation and repair
Topic
182
Cancer Biology
17092
A 46-year-old female comes into the ED with a fever of 39.6 degrees. The ED doctor wants to give a targeted therapy for the specific molecules which cause this high fever.

Which molecule causes this fever and where does it act upon?
a