QuestionSBA
QuestionChoice
There is no lateral zone of the prostate. The three recognised zones are central, transitional, and peripheral. The fibromuscular stroma of the prostate is sometimes considered the fourth zone.
10000389
d
Lateral zone
QuestionChoice
The fibromuscular stroma is sometimes considered to be the fourth zone of the prostate. It is situated at the anterior of the gland and merges with the urogenital diaphragm. Prostatic malignancy does not typically arise in the fibromuscular stroma.
10000390
e
Stromal zone
QuestionChoice
Prostate cancer most commonly arises in the peripheral zone of the prostate (70-80%). The prostate has three zones: central, transitional, and peripheral. The peripheral zone is the largest zone of the prostate, making up approximately 65% of the total volume and lies to the posterior of the gland, anterior to the rectum. Prostate malignancy is most commonly adenocarcinoma.
10000386
a
Peripheral Zone
QuestionChoice
Only ~20% of prostate malignancies arise in the transitional zone. The transitional zone encircles the urethra. Although not the most common location for malignancy, the transitional zone is the most common zone for benign prostatic hyperplasia to arise.
10000387
b
Transitional zone
QuestionChoice
This zone has the lowest occurrence of prostate malignancy, with only ~5% of malignancies occurring in this zone. The central zone surrounds the ejaculatory ducts.
10000388
c
Central zone
Concept
Chapter
2693
3755
Prostate cancer
Topic
143
Urology
12624
A 76-year-old male presents to General Practice with a 3-month history of urinary hesitancy and frequency. He does not report any other symptoms. Digital rectal examination reveals an asymmetrical, hard, nodular prostate. You suspect a diagnosis of prostate cancer and arrange an urgent referral to urology.

Which of the following zones of the prostate is most commonly involved in malignancy?
a