QuestionSBA
QuestionChoice
The most likely diagnosis is systemic lupus erythematosus (SLE). 99% of patients with SLE are ANA positive.
10027821
a
Anti-nuclear antibodies (ANA)
QuestionChoice
This is the pathophysiology of myasthenia gravis, which does not match the symptoms of this woman.
10027822
b
Anti-acetylcholine receptor antibodies
QuestionChoice
This is the autoantibody driving Grave's disease. Antibodies against the thyroid-stimulating hormone (TSH) receptor are formed causing hyperthyroidism.
10027825
e
Anti-TSH receptor
QuestionChoice
This autoantibody is positive in patients with polymyositis. This patient has features of SLE: malar rash, fatigue, joint pains and thrombocytopenia.
10027824
d
Anti-Jo-1
QuestionChoice
This is the autoantibody-positive in rheumatoid arthritis, it can be positive in patients with SLE but is less likely than ANA.
10027823
c
Anti-Rheumatoid factor
Concept
Chapter
2693
6005
Autoantibodies
Topic
158
Immunology
17962
A 20-year-old woman presents with ongoing fatigue, joint pains and alopecia. She has also noticed she is bruising more easily. On examination, there is an erythematous rash across her cheeks.

Given the most likely diagnosis, which autoantibody is most likely to be positive?
a