QuestionSBA
QuestionChoice
This is incorrect. Aldosterone does not directly affect GFR. It exerts its effects by increasing the expression of epithelial sodium channels (ENaCs) in the collecting ducts of the nephron. This brings about the reabsorption of sodium and excretion of potassium.
10026087
c
Increases glomerular filtration rate (GFR)
QuestionChoice
This is incorrect. ADH primarily regulates water reabsorption in the collecting ducts. Aldosterone exerts its effects by increasing the expression of epithelial sodium channels (ENaCs) in the collecting ducts of the nephron. This brings about the reabsorption of sodium and excretion of potassium.
10026089
e
Stimulates the secretion of antidiuretic hormone (ADH)
QuestionChoice
This is correct. Aldosterone is a mineralocorticoid that is released from the zona glomerulosa of the adrenal cortex. It exerts its effects by increasing the expression of epithelial sodium channels (ENaCs) in the collecting ducts of the nephron. This brings about the reabsorption of sodium and excretion of potassium.
10026085
a
Increases the expression of epithelial sodium channels in the collecting ducts
QuestionChoice
This is incorrect. While the sodium-potassium pump is involved in sodium reabsorption, aldosterone primarily acts on the collecting ducts, not the proximal tubules. It exerts its effects by increasing the expression of epithelial sodium channels (ENaCs) in the collecting ducts of the nephron. This brings about the reabsorption of sodium and excretion of potassium.
10026086
b
Directly stimulates the sodium-potassium pump (Na+/K+ pump) in the proximal tubules
QuestionChoice
This is incorrect. This describes the mechanism of ACE inhibitors such as ramipril, which reduces angiotensin II levels. Aldosterone exerts its effects by increasing the expression of epithelial sodium channels (ENaCs) in the collecting ducts of the nephron. This brings about the reabsorption of sodium and excretion of potassium.
10026088
d
Inhibits angiotensin-converting enzyme (ACE)
Concept
Chapter
2693
3896
Actions of aldosterone
Topic
168
Renal Physiology
17615
A 56-year-old woman presents to her General Practitioner for a review of her chronic hypertension. She has been on ramipril and amlodipine for a number of years, but her blood pressure has been consistently elevated. The patient is keen to learn more about the hormones involved in the regulation of blood pressure.

Which of the following best describes the action of aldosterone?
a