QuestionSBA
QuestionChoice
Tamoxifen increases risk of thromboembolism. Hence, patients should seek medical attention straightaway if they suddenly experience breathlessness, chest pain and other signs that are suggestive of pulmonary embolus
34155
a
She should immediately seek medical help if she experiences sudden onset breathlessness and chest pain
QuestionChoice
Cataract is a common side effect while corneal changes are rarely caused by Tamoxifen
34159
e
Tamoxifen more commonly causes corneal changes than cataract
QuestionChoice
Angioedema is a rare side effect of tamoxifen
34158
d
Angioedema is a common side effect of tamoxifen
QuestionChoice
Tamoxifen is contraindicated during pregnancy due to its teratogenicity. Patients should use effective contraception during treatment and for 2 months after cessation of treatment
34156
b
She could attempt to get pregnant during the course of treatment
QuestionChoice
Tamoxifen is associated with increased endometrial changes that can subsequently lead to hyperplasia, polyps and cancer
34157
c
Tamoxifen reduces the risk of endometrial hyperplasia and polyps
Concept
Chapter
#### Monitoring

The BNF advises to monitor lung function (in patients with a history of obstructive airway disease).

#### Overdoses

Overdosages with beta-blockers may cause cardiac effects such as bradycardia, hypotension, syncope, conduction abnormalities, and heart failure. Bradycardia is the most common arrhythmia, but some beta-blockers may induce ventricular tachyarrhythmias secondary to prolongation of QT interval (e.g. sotalol) or QRS duration (e.g. propranolol).
Non-cardiovascular effects include central nervous system effects (including drowsiness, confusion, convulsions, hallucinations, and in severe cases coma), respiratory depression, and bronchospasm.

Management
 - Airway protection 
 - Activated charcoal within 1 hour
 - IV Fluids
 
IV glucagon is the first-line management.
 
For symptomatic bradycardia, IV atropine may be used.

2618
2774
Tamoxifen
Topic
76
Obstetrics and Gynaecology
6842
Case presentation: A 35-year-old woman attends the breast clinic to discuss about hormonal therapy for her oestrogen-receptor positive breast cancer.  

PMH: Breast cancer, Hypertension
DH: Amlodipine 5mg OD
SH: Lives alone, smoker (10 pack-year history)
She is advised to commence treatment with Tamoxifen 20mg PO daily.

Question: Select the most appropriate information that should be provided for this patient.
a