QuestionSBA
QuestionChoice
Warfarin only affects the extrinsic pathway by inhibiting factors II, VII, IX and X.
10001428
b
Inhibits the intrinsic pathway
QuestionChoice
Examples of antiplatelet drugs include clopidogrel and aspirin.
10001431
e
Inhibits platelet aggregation
QuestionChoice
Anticoagulants such as apixaban inhibit Factor Xa in the common pathway.
10001429
c
Factor Xa inhibitor
QuestionChoice
Examples of direct thrombin inhibitors include dabigatran.
10001430
d
Inhibits thrombin
QuestionChoice
Warfarin acts on the extrinsic pathway by inhibiting factors II, VII, IX and X. This is because warfarin inhibits vitamin K epoxide reductase, reducing the levels of vitamin K available to activate factors II, VII, IX and X. A useful mnemonic is 1972 WEPT where 1972 refers to factors 10, 9, 7 and 2 being inhibited, and W = Warfarin, E = extrinsic pathway affected, PT = PT prolonged.
10001427
a
Factor II, VII, IX, X inhibitor
Concept
Chapter
2693
3928
coagulation cascade
Topic
157
Haematology
12832
A 70-year-old female with a deep vein thrombosis (DVT) is prescribed warfarin as treatment.

What is the mechanism of action of warfarin?
a