QuestionSBA
QuestionChoice
This is incorrect. Statins inhibit HMG-CoA reductase. Lipoprotein lipase (LPL) is responsible for the absorption of exogenous lipids by breaking down chylomicrons to release free fatty acids which are then taken up by cells.
10025982
c
Inhibits lipoprotein lipase
QuestionChoice
This is incorrect. Statins inhibit HMG-CoA reductase. Acetyl-CoA carboxylase is responsible for the conversion of acetyl-CoA to malonyl-CoA in the fatty acid synthesis pathway.
10025983
d
Inhibits acetyl-CoA carboxylase
QuestionChoice
This is correct. Statins inhibit HMG-CoA reductase, which catalyses the rate-limiting step in cholesterol synthesis. This prevents plaque buildup (atherosclerosis), thus reducing the risk of future MIs.
10025980
a
Inhibits HMG-CoA reductase
QuestionChoice
This is incorrect. Statins inhibit HMG-CoA reductase. Carnitine acetyltransferase facilitates the transfer of long-chain fatty acids to the mitochondria for β-oxidation.
10025984
e
Inhibits carnitine acetyltransferase
QuestionChoice
This is incorrect. Statins inhibit HMG-CoA reductase. Increasing synthesis of HMG-CoA reductase would increase cholesterol synthesis, and thus increase the risk of a future MI.
10025981
b
Increases synthesis of HMG-CoA reductase
Concept
Chapter
2693
4116
Statins
Topic
169
Cardiovascular pharmacology
17594
A 62 year old man presents to the Emergency Department describing a crushing, left sided chest pain that radiates down the left arm and is associated with nausea. No ST-segment elevation is seen on electrocardiogram, but repeat troponin levels are raised. He is diagnosed with a myocardial infarction (MI).

As part of the secondary prevention regime, he is prescribed atorvastatin 80mg.

Which of the following describes the mechanism of action of atorvastatin?
a