QuestionSBA
QuestionChoice
This is correct. Metformin is a biguanide medication that reduces gluconeogenesis in the liver and increases glucose uptake, therefore improving insulin sensitivity. This is the first-line oral anti-diabetic drug.
10027546
a
Increased insulin sensitivity
QuestionChoice
This is incorrect. Thiazolidenediones such as Pioglitazone have this mechanism of action. This promotes increased storage of free fatty acids reducing the amount available to be used by the cells. Peripheral tissues therefore become more depending on carbohydrates for energy.
10027547
b
Stimulates nuclear receptor (peroxisome proliferator activated receptors)
QuestionChoice
This is incorrect. This is the mechanism of action of GLP-1 analogues such as Liraglutide. These stimulate insulin release and inhibit glucagon release.
10027548
c
Incretin effects
QuestionChoice
This is incorrect. Sulfonylureas work in this way by closing ATP sensitive potassium channels on pancreatic beta cells causing membrane depolarisation and a calcium influx into the cell. This leads to insulin secretion.
10027550
e
Increased insulin release
QuestionChoice
This is incorrect. Dapagliflozin is an example of a medication with this mechanism of action. THey work by binding to SGLT2 receptors in the proximal convoluted tubule leading to increased glycosuria and reduced reabsorption of glucose.
10027549
d
Sodium dependent glucose cotransporter 2 inhibitor
Concept
Chapter
2693
4376
Metformin
Topic
220
Endocrine Pharmacology
17907
A 52 year old female attends her GP surgery to discuss her latest blood results, which show an HbA1c of 55 and a new diagnosis of type 2 diabetes. The GP recommends taking metformin to manage her diabetes.

Which of the following describes the mechanism of action of metformin?
a