QuestionSBA
QuestionChoice
Gilbert's syndrome typically does not cause damage to hepatocytes and thus would not result in a rise in ALT.
10006963
c
Increased unconjugated bilirubin and raised ALT
QuestionChoice
Gilbert's disease is a cause of prehepatic jaundice due to reduced bilirubin conjugation enzyme (UGT) activity during times of stress. In this patient, with known Gilbert's syndrome, the COVID-19 infection is likely to be the trigger for his jaundice. Blood tests would show an unconjugated hyperbilirubinaemia. However, there is typically no damage to liver cells so other liver function tests would remain normal.
10006961
a
Increased unconjugated bilirubin only
QuestionChoice
Gilbert's syndrome would result in a high unconjugated bilirubin and a normal ALT.
10006965
e
Normal bilirubin and high ALT
QuestionChoice
Increased conjugated bilirubin would occur in hepatic or post-hepatic causes of jaundice. However, Gilbert's syndrome is a pre-hepatic cause resulting in an unconjugated hyperbilirubinaemia. Hepatic and post-hepatic causes of jaundice may also be associated with damage to hepatocytes resulting in deranged liver function tests.
10006962
b
Increased conjugated bilirubin only
QuestionChoice
Gilbert's syndrome would not cause a conjugated hyperbilirubinaemia or a rise in ALT.
10006964
d
Increased conjugated bilirubin and high ALT
Concept
Chapter
2693
4049
Jaundice
Topic
136
Gastroenterology
13939
A 46-year-old man with a known history of Gilbert's syndrome presents with fever, dry cough, shortness of breath and jaundice. A COVID-19 test is performed which is positive.

Which of the following blood test results would you most expect to see in this patient?
a