QuestionSBA
QuestionChoice
Incorrect. This scenario suggests an anaemia of chronic disease. Iron transporters (ferroportin) are involved in anaemia of chronic disease but they are not affected in this way.
10002867
b
Cancer cells stimulate necrosis of iron transporters in intestinal cells
QuestionChoice
Correct. This scenario suggests an anaemia of chronic disease. Chronic disease precipitates the formation of inflammatory cytokines such as IL-6. Ferroportin is involved in transporting absorbed iron into the bloodstream, so when activity of this is decreased less haemoglobin can be made.
10002866
a
High levels of IL-6 stimulate hepcidin release from the liver which decreases the activity of ferroportin
QuestionChoice
Incorrect. This describes sideroblastic anaemia, whereas the scenario suggests anaemia of chronic disease.
10002870
e
Ineffective erythropoiesis leads to increased iron absorption
QuestionChoice
Incorrect. This describes pernicious anaemia, whereas the scenario suggests anaemia of chronic disease. Intrinsic factor is involved in the absorption of Vitamin B12.
10002869
d
Autoimmune destruction of the parietal cells in the stomach, leading to decreased production of intrinsic factor
QuestionChoice
Incorrect. This describes aplastic anaemia, whereas the scenario suggests anaemia of chronic disease.
10002868
c
Pancytopenia with hypocellular bone marrow
Concept
Chapter
2693
4085
Anaemia of Chronic Disease
Topic
157
Haematology
13120
A 65 year old female patient presents with new diagnosis of lung cancer and is incidently found to have an anaemia.

What is the most likely pathophysiology of this type of anaemia?
a