QuestionSBA
QuestionChoice
Bendroflumethazide belongs to the thiazide class of diuretics. The sodium/amino acid symporter plays no role in the mechanism of action of thiazide diuretics but is instead responsible for the reabsorption of amino acids.
10025759
e
Sodium/amino acid symporter in the proximal convoluted tubule
QuestionChoice
Bendroflumethazide belongs to the thiazide class of diuretics. The sodium/glucose linked transporter is not involved in the mechanism of action of thiazide diuretics but is the target of SGLT2 inhibitors such as empagliflozin, which is used in diabetes treatment.
10025757
c
Sodium glucose linked transporter in the proximal convoluted tubule
QuestionChoice
Bendroflumethazide belongs to the thiazide class of diuretics. These drugs block the sodium-chloride symporter in the distal convoluted tubule. By contrast, sodium-potassium-chloride co-transporters are the target of loop diuretics. Whilst they work similarly to thiazide diuretics by stopping the reabsorption of sodium and thus reducing water reabsorption, they act upon a different transporter, making this option incorrect.
10025758
d
Sodium-potassium-chloride co-transporters of the thick ascending limb
QuestionChoice
Bendroflumethazide belongs to the thiazide class of diuretics. Whilst thiazide diuretics do block the sodium-chloride symporter, this blockade occurs in the distal convoluted tubule not the proximal, meaning this option is incorrect.
10025756
b
Sodium-chloride symporter in the proximal convoluted tubule
QuestionChoice
Bendroflumethazide belongs to the thiazide class of diuretics. These drugs block the sodium-chloride symporter in the distal convoluted tubule, preventing the reabsorption of sodium and chloride. Remember water follows sodium so less water is also reabsorbed, reducing the circulating blood volume which in turn decreases cardiac pre-load and thus blood pressure.
10025755
a
Sodium-chloride symporter in the distal convoluted tubule
Concept
Chapter
2693
5764
Thiazide diuretics
Topic
188
Renal Pharmacology
17549
A 65 year old patient with hypertension which has failed to be controlled by first-line therapy is prescribed bendroflumethazide.

Which of the following parts of the nephron does this class of diuretic act upon?
a