QuestionSBA
QuestionChoice
D2 (dopamine) receptors are inhibitory. D2 activation in the striatum inhibits the indirect pathway, leading to promoting movement. Antipsychotics antagonise D2 receptors. With long-term use, the brain adapts by upregulating more receptors to the synapse. This upregulation of D2 is irreversible. This results in promotion of movement, and movement disorders called tardive dyskinesia.
10000801
a
D2
QuestionChoice
GABA a receptors are inhibitory ionotropic receptors. Antipsychotics may affect GABA and its receptors, but this is not their primary mechanism of action.
10000805
e
GABA a
QuestionChoice
Typical (newer) antipsychotics affect various serotonin receptors. However, serotonin is not involved in movement.
10000802
b
5-HT2a
QuestionChoice
Reduction of NMDA receptors has a role in the development of schizophrenia. Antipsychotics do not directly affect NMDA receptors.
10000804
d
NMDA
QuestionChoice
Muscarinic receptors M1, M3, and M5 are found in smooth muscles and glands. Antagonism of these receptors causes hypersalivation in patients on certain antipsychotics (such as clozapine).
10000803
c
M3
Concept
Chapter
2693
3828
Side effects of antipsychotics
Topic
173
Psychiatry
12707
Long-term antipsychotic use can cause movement disorders such as tardive dyskinesia.

Upregulation of which receptor is responsible for this?
a