QuestionQA
QuestionComment
why is round to nearest 40 mean 360, wouldnt the nearest multiple of 40 be 380?
6653
QuestionComment
Because 360 is a multiple of 40 (360 / 40 = 9). 380 isn't (380 / 40 = 9.5)
6708
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Thermoregulator Zygomatic
QuestionComment
Ain’t nobody got time to do all this mathematics in the 1 min per question time pressures of PSA land
17569
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Zika Biopsy
QuestionComment
Because up to 200 would be 20, 40, 60, etc. After 200, its 240 --> 280 --> 320 --> 360 (360 is closest to 350)
18382
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Poisoning Tanoy
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Dr Brighton
Concept
Chapter
#### Monitoring

The BNF advises to monitor lung function (in patients with a history of obstructive airway disease).

#### Overdoses

Overdosages with beta-blockers may cause cardiac effects such as bradycardia, hypotension, syncope, conduction abnormalities, and heart failure. Bradycardia is the most common arrhythmia, but some beta-blockers may induce ventricular tachyarrhythmias secondary to prolongation of QT interval (e.g. sotalol) or QRS duration (e.g. propranolol).
Non-cardiovascular effects include central nervous system effects (including drowsiness, confusion, convulsions, hallucinations, and in severe cases coma), respiratory depression, and bronchospasm.

Management
 - Airway protection 
 - Activated charcoal within 1 hour
 - IV Fluids
 
IV glucagon is the first-line management.
 
For symptomatic bradycardia, IV atropine may be used.

2618
2862
Weight-based dosing; calculation of infusion rate
Topic
13
Neurosurgery
The dose of gentamicin to be given is: 70kg x 5mg/kg = 350mg. As this is above 200mg, this is rounded up to the nearest 40mg, which is 360mg. Since this is given over 60 minutes, the dose given per minute is: 360mg ÷ 60 minutes = 6mg/min.

The fact that his BMI and creatinine clearance are both normal mean that additional calculations to account for extremes of body weight and impaired renal function respectively are not required. In addition, the volume of 0.9% sodium chloride required for dilution is a distraction.
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QuestionQAAnswer
6
mg/min
A 62-year-old patient who weighs 70kg suffers from acute pyelonephritis. He is prescribed a gentamicin infusion of 5mg/kg using a once-daily regimen. The dose is rounded up to the nearest 20mg increment for doses less than 200mg and 40mg above this.


Gentamicin is diluted in 50mL of 0.9% sodium chloride and given over 60 minutes. His BMI and creatinine clearance are both within normal limits.

What is the dose of gentamicin given per minute?