QuestionSBA
QuestionChoice
This answer is incorrect. The collecting duct is the site of action of potassium sparing diuretics such as spironolactone and amiloride. Furosemide acts on the ascending limb of the loop of Henle.
10007424
d
Collecting duct
QuestionChoice
This answer is incorrect. Furosemide acts at the ascending limb of the loop of Henle where it binds to the Na/K/Cl cotransporter.
10007422
b
Loop of Henle - descending limb
QuestionChoice
This answer is incorrect. The distal convoluted tubule is the site of action of thiazide diuretics such as bendroflumethiazide. Furosemide acts on the ascending limb of the loop of Henle.
10007423
c
Distal convoluted tubule
QuestionChoice
This answer is correct. Furosemide inhibits the Na/K/Cl cotransporter in the thick ascending limb of the loop of Henle. This causes more sodium, chloride, potassium, and water to be excreted in the urine.
10007421
a
Loop of Henle - ascending limb
QuestionChoice
This answer is incorrect. The proximal convoluted tubule is the site of action of carbonic anhydrase inhibitors such as acetazolamide. Furosemide acts on the ascending limb of the loop of Henle.
10007425
e
Proximal convoluted tubule
Concept
Chapter
2693
4018
Furosemide
Topic
188
Renal Pharmacology
14031
A 82-year-old woman with a history of heart failure attends A&E with worsening shortness of breath.

On examination, she has bibasal crackles, a raised JVP, and bilateral pitting oedema to the mid-thigh.

As part of her treatment, she is commenced on IV furosemide.

Which of the following describes the site of action of furosemide?
a