QuestionSBA
QuestionChoice
Yes, this is the correct mechanism of action. Carbimazole prevents the coupling and iodination of tyrosines on thyroglobulin, thus reducing the production of thyroid hormones. This in turn relieves the symptoms or hyperthyroidism.
10007830
a
Prevents the coupling and iodination of tyrosine on thyroglobulin which is catalysed by the enzyme thyroid peroxidase
QuestionChoice
No, this is not the correct mechanism of action.
10007833
d
Prevents the exit of T3 and T4 hormones out of the thyroid follicular cells by blocking the T3/T4 export protein
QuestionChoice
No, this is not the correct mechanism of action.
10007832
c
Preventing the entry of iodine into the thyroid follicular cells by blocking the basolateral Na+/I- symporter
QuestionChoice
No, this is not the correct mechanism of action. The coupling and iodination of tyrosine on thyroglobulin does not occur through apoptosis, but rather is catalysed by the enzyme thyroid peroxidase.
10007831
b
Prevents the coupling and iodination of tyrosine on thyroglobulin through apoptosis
QuestionChoice
No, this is not the correct mechanism of action.
10007834
e
Inhibition of endocytosis of thyroglobulin from the colloid into the thyroid follicular cells
Concept
Chapter
2693
3959
Hyperthyroidism
Topic
133
Endocrinology
14113
A 53-year-old woman presents to the endocrinology clinic with fatigue, weakness, excessive sweating, and heat intolerance. On examination, she has a neck lump which elevates when swallowing.


A series of thyroid function tests are as follows:

||||
|---------------------------|:-------:|------------------------------|
|Thyroid Stimulating Hormone|<0.05 mU/L|0.3 - 4.2|
|Total T4|4.5 nmol/L|60 - 150|
|Total T3|202 pmol/L|3.1 - 6.8|


The patient also tests positive for thyroid stimulating immunoglobulin antibodies (TSI), hence a diagnosis of Grave's disease is made. She is prescribed carbimazole to manage her symptoms.


Which of the following best describes the mechanism of action of carbimazole?
a