QuestionSBA
QuestionChoice
In Von Willebrand disease, the prothrombin time (PT) is normal and activated partial thromboplastin time (APTT) and bleeding time are prolonged. The PT is normal because the extrinsic pathway of the clotting cascade is unaffected.
10001411
e
Von Willebrand disease
QuestionChoice
Haemophilia A is an X-linked recessive bleeding disorder, hence is primarily seen in males. It results in a deficiency in factor VIII which is involved in the intrinsic pathway of the clotting cascade, measured using activated partial thromboplastin time (APTT). It often presents in young males with haemarthrosis, as demonstrated by this patient.
10001407
a
Haemophilia A
QuestionChoice
Trauma is a good differential for bleeding in joints. However, the coagulation screen suggests an underlying bleeding disorder.
10001409
c
Trauma
QuestionChoice
The hot, swollen, painful joint in this case could suggest septic arthritis. However, a patient with septic arthritis would also present with systemic symptoms such as fever and lethargy.
10001410
d
Septic arthritis
QuestionChoice
Haemophilia B is an X-linked recessive bleeding disorder that results in a deficiency in clotting factor IX. Factor IX is involved in the extrinsic pathway of the clotting cascade, which is measured using prothrombin time (PT). Haemophilia B is less common than Haemophilia A, so it is not the most likely diagnosis.
10001408
b
Haemophilia B
Concept
Chapter
2693
3925
haemophilia
Topic
157
Haematology
12828
A 4-year-old boy presents to A&E with a painful, hot, swollen left knee. His parents explain that he gets recurrent nosebleeds and often bruises easily. Blood results show an increased PT, increased APTT and normal bleeding time.

What is the most likely diagnosis?
a