QuestionSBA
QuestionChoice
This is incorrect. The substantia nigra includes two pathways, intrinsic and extrinsic, which together are responsible for the initiation of movement. The neurons within these pathways are dopaminergic, not serotonergic.
10025846
b
Serotonergic cells of the substantia nigra
QuestionChoice
This is incorrect. The main location of pathology in Parkinson's disease is the substantia nigra, located within the basal ganglia.
10025849
e
Dopaminergic cells of the medulla oblongata
QuestionChoice
This is incorrect. Damage to neuronal myelin sheaths is not specifically implicated in Parkinson's disease. The myelin sheath is wrapped around the axon and allows action potentials to be conducted at a faster pace. Damage to the myelin sheath in the central nervous system is seen in conditions such as multiple sclerosis.
10025848
d
Myelin sheath of the central nervous system
QuestionChoice
This is correct. Whilst the exact cause of Parkinson's disease is unclear, it is believed to be caused by the loss of dopaminergic neurons in the substantia nigra of the basal ganglia. Functions of the basal ganglia include the initiation of movement, motor learning and motor control.
10025845
a
Dopaminergic cells of the substantia nigra
QuestionChoice
This is incorrect. The main location of pathology in Parkinson's is the substantia nigra, located within the basal ganglia.
10025847
c
Dopaminergic cells of the cerebellum
Concept
Chapter
2693
5865
Parkinsonism
Topic
141
Neurology
17567
A 72 year old male attends neurology clinic regarding a new diagnosis of Parkinson's disease. The patient has been having recurrent falls and his wife has noticed he moves a lot slower than he used to, and has developed a tremor that is worse on the right-hand side. On examination, the patient demonstrates 'cog wheel' rigidity and a 'pill-rolling' tremor of the right hand.

Which of the following neuronal subtypes are lost in Parkinson's disease?
a