QuestionSBA
QuestionChoice
In neuropathic pain conditions, there can be impairments in the descending inhibition system. The brain may not effectively send inhibitory signals to the spinal cord to modulate the pain signals coming from damaged or malfunctioning nerves. The neurotransmitters that are typically involved include serotonin, noradrenaline and opioids.
10026720
a
Descending inhibition
QuestionChoice
There is synaptic reorganisation within the spinal cord. This results in allodynia in neuropathic pain.
10026723
d
Synaptic reorganisation
QuestionChoice
There is an increase in the Sodium channel gene expression resulting in increased excitability of the nociceptors in neuropathic pain.
10026722
c
Sodium channel activity
QuestionChoice
There is an increase in the inflammatory cells and mediators as opposed to a decrease in neuropathic pain. They result in direct receptor-mediated excitatory effects which have both short and long-term effects on neuronal excitability.
10026721
b
Inflammatory cells and mediators
QuestionChoice
Catastrophising personality can amplify the pain experience and this tends to happen more in patients with neuropathic pain.
10026724
e
Catastrophising personality
Concept
Chapter
2693
3825
Pain sensation
Topic
152
Neuroscience
17742
A 54-year-old male presents to the pain clinic. He has been experiencing neuropathic pain after having had a stroke. He would like to know more about his pain.

Which protective mechanism is reduced in neuropathic pain?
a