QuestionSBA
QuestionChoice
Monotherapy with either trimethoprim or nitrofurantoin is first-line in the management of urinary tract infection according to NICE guidelines. Pivmecillinam is used second-line if no improvement is seen in lower UTI symptoms after taking the first-line antibiotic taken for at least 48 hours, or when the first choice is not suitable.
10001500
d
Pivmecillinam
QuestionChoice
Monotherapy with either trimethoprim or nitrofurantoin is first-line in the management of urinary tract infections according to NICE guidelines. Trimethoprim works by inhibiting folic acid production. This patient is already established on methotrexate for rheumatoid arthritis. Methotrexate is an anti-folate drug, and therefore other anti-folate drugs should be avoided. Examples of anti-folate drugs include methotrexate, trimethoprim, pemetrexed and proguanil (anti-malarial). Patients taking anti-folate medication should be counselled on their medication and have supplemental folic acid on a different day to their methotrexate dose.
10001497
a
Trimethoprim
QuestionChoice
Monotherapy with either trimethoprim or nitrofurantoin is first-line in the management of urinary tract infection according to NICE guidelines. Common side effects of gentamicin include ototoxicity and nephrotoxicity. Gentamicin is not used in the treatment of a simple urinary tract infection.
10001499
c
Gentamicin
QuestionChoice
Monotherapy with either trimethoprim or nitrofurantoin is first-line in the management of urinary tract infection according to NICE guidelines. Cefalexin is used second-line in pregnant women aged 12+ if no improvement is seen in lower UTI symptoms on first-line antibiotic taken for at least 48 hours, or when the first choice is not suitable.
10001501
e
Cefalexin
QuestionChoice
Monotherapy with either trimethoprim or nitrofurantoin is first-line in the management of urinary tract infections according to NICE guidelines. This patient is likely to be commenced on nitrofurantoin for management of her UTI.
10001498
b
Nitrofurantoin
Concept
Chapter
2693
3936
Methotrexate
Topic
146
Rheumatology
12846
A 57-year-old female attends the rheumatology outpatient department for a review of her methotrexate. She mentions that she has been experiencing burning when passing urine. She is diagnosed with a urinary tract infection (UTI). The doctor is aware that caution must be taken when prescribing a specific antibiotic.

To which antibiotic is he referring?
a