QuestionSBA
QuestionChoice
Depolarising muscle agents cause fasciculations (muscle twitching), just before paralysis occurs, as these agents work by depolarising the motor end plate.
10004723
c
They cause muscle fasciculations
QuestionChoice
Non-depolarising agents are competitive antagonists of the nicotinic acetylcholine receptor, meaning that they block the receptor from letting in cations, so muscle relaxation is achieved. Depolarising agents are agonists of the receptor, causing receptor activation and cation influx.
10004724
d
They activate the nicotinic acetylcholine receptor, allowing cation influx
QuestionChoice
Succinylcholine is a depolarising agent that causes muscle relaxation.
10004725
e
Succinylcholine is another non-depolarising agent that causes muscle relaxation
QuestionChoice
As non-depolarising agents are competitive antagonists of the nicotinic acetylcholine receptor, an increase in acetylcholine will out-compete the drug for the receptor binding sites. Blocking the enzymes that break down acetylcholine allows this to occur.
10004721
a
Their action is reversed by acetylcholinesterases
QuestionChoice
Non-depolarising agents are competitive antagonists of the nicotinic acetylcholine receptor. They compete with acetylcholine for the orthosteric ligand binding site.
10004722
b
They bind to an allosteric site of the nicotinic acetylcholine receptors
QuestionComment
Surely you mean "action is reversed by antiacetylcholinesterases" 
23302
User
subscriber
Agent Acromegaly
Concept
Chapter
2693
4324
Non-depolarising agents
Topic
172
Pharmacology of the Nervous System
13491
Which of the following statements about non-depolarising agents, such as atracurium and vecuronium, is true?
a