QuestionSBA
QuestionChoice
Formaldehyde is a toxic and carcinogenic substance used as a disinfectant and preservative. It is not involved in the metabolism of paracetamol.
10007128
c
Formaldehyde
QuestionChoice
NAC is used to treat paracetamol overdose, when the patient has presented an hour past the time of ingestion, or when the magnitude of the overdose is unknown.
10007130
e
N-acetyl-cysteine (NAC)
QuestionChoice
Acetaldehyde is a toxic substance produced as a byproduct of alcohol metabolism. It is not a metabolite of paracetamol.
10007129
d
Acetaldehyde
QuestionChoice
This is the normal conjugation partner of paracetamol in cases of therapeutic dosing.
10007127
b
Glucuronide
QuestionChoice
Paracetamol is metabolised by cytochrome p450 enzymes. In overdose, the metabolic pathways by which paracetamol is normally conjugated with glucuronic acid become saturated, leading to the accumulation of NAPQI. This can cause hepatocellular damage and liver failure.
10007126
a
N-acetyl-p-benzoquinone imine (NAPQI)
Concept
Chapter
2693
4048
Paracetamol Overdose
Topic
136
Gastroenterology
13972
A 50-year-old man presents to the emergency department with abdominal pain, nausea, and vomiting after taking an overdose of paracetamol.

Which of the following toxic compounds is produced by paracetamol metabolism?
a