QuestionSBA
QuestionChoice
Incorrect - Fibroblasts migrate to and proliferate at the site of an injury and deposit extracellular matrix. They are not responsible for bone resorption.
10008469
e
Fibroblasts
QuestionChoice
Incorrect - Osteocytes were once osteoblasts which have become trapped within the matrix they secreted. They are not involved in bone resorption.
10008467
c
Osteocytes
QuestionChoice
Correct - Osteoclasts secrete enzymes and acid to break down extracellular matrix and mineralised bone to facilitate resorption. They are the primary cell type driving bone destruction, as is necessary for remodelling and repair. An imbalance of osteoclasts and osteoblasts, which are responsible for bone production, can lead to bone disorders such as osteoporosis.
10008465
a
Osteoclasts
QuestionChoice
Incorrect - Osteoblasts are responsible for bone production. They secrete osteoid (the organic bone matrix containing type 1 collagen) which is then mineralised to form bone. They are not involved in bone resorption.
10008466
b
Osteoblasts
QuestionChoice
Incorrect - Basophils are a type of granulocyte. They are involved in immune response and the immune system. They are not involved in bone resorption.
10008468
d
Basophils
Concept
Chapter
2693
4673
Osteoclasts
Topic
154
Musculoskeletal physiology and disease
14240
A 54-year-old woman visits her GP as she is concerned that she might have osteoporosis. She asks the doctor if there are any tests that can be done to make sure her bones are healthy.

Which of the following is the main cell involved in bone resorption?
a