QuestionSBA
QuestionChoice
The volume of distribution is the theoretical volume which would be needed to contain a dose of a drug in order to keep it at the same concentration as the required plasma concentration.  Midazolam must reach 10mg/L within the plasma, and the dose being given is 25mg. Therefore, Vd = 25 /10 = 2.5 because Vd = Dose (mg) / Plasma concentration (mg/L). The dose is divided by the plasma concentration, not multiplied. Also, it is 'volume' of distribution, so the units are 'L' not 'mg'.
10000709
d
250mg
QuestionChoice
The correct calculation has been carried out here, as the volume of distribution is the theoretical volume which would be needed to contain a dose of a drug in order to keep it at the same concentration as the required plasma concentration.  Midazolam must reach 10mg/L within the plasma, and the dose being given is 25mg. Therefore, Vd = 25 /10 = 2.5 because Vd = Dose (mg) / Plasma concentration (mg/L). However, given it is 'volume' of distribution, the units are 'L' not 'mg'.
10000708
c
2.5mg
QuestionChoice
The volume of distribution is the theoretical volume which would be needed to contain a dose of a drug in order to keep it at the same concentration as the required plasma concentration. Midazolam must reach 10mg/L within the plasma, and the dose being given is 25mg. Therefore, Vd = 25 /10 = 2.5 because Vd = Dose (mg) / Plasma concentration (mg/L).
10000706
a
2.5L
QuestionChoice
The volume of distribution is the theoretical volume which would be needed to contain a dose of a drug in order to keep it at the same concentration as the required plasma concentration. Midazolam must reach 10mg/L within the plasma, and the dose being given is 25mg. Therefore, Vd = 25 /10 = 2.5 because Vd = Dose (mg) / Plasma concentration (mg/L).
10000710
e
15L
QuestionChoice
The volume of distribution is the theoretical volume which would be needed to contain a dose of a drug in order to keep it at the same concentration as the required plasma concentration.  Midazolam must reach 10mg/L within the plasma, and the dose being given is 25mg. Therefore, Vd = 25 /10 = 2.5 because Vd = Dose (mg) / Plasma concentration (mg/L). The dose is divided by the plasma concentration, not multiplied.
10000707
b
250L
Concept
Chapter
2693
3811
Apparent volume of distribution
Topic
166
General pharmacological concepts
12688
A patient is prescribed 25mg of Midazolam. It must reach a plasma concentration of 10mg/L for it to take effect.

What is the volume of distribution (Vd) for this dose of Midazolam?
a