QuestionSBA
QuestionChoice
Cystic fibrosis (CF) is an autosomal recessive inheritance pattern caused by inheriting 2 recessive alleles from the parents. CF is caused by a mutation on chromosome 7 affecting the CFTR gene. Chloride is therefore secreted abnormally and there is increased sodium absorption resulting in thick mucus lining the airways causing cilia impairment.
10000026
a
Autosomal recessive
QuestionChoice
Cystic fibrosis is an autosomal recessive disease. An example of an x-linked recessive disorder would be Duchenne muscular dystrophy.
10000028
c
X-linked recessive
QuestionChoice
Cystic fibrosis is an autosomal recessive disease. An example of autosomal dominant inheritance would be Huntington's disease.
10000027
b
Autosomal dominant
QuestionChoice
Cystic fibrosis is an autosomal recessive disease. An example of a mitochondrial inherited disorder would be chronic progressive external ophthalmoplegia (CPEO) characterised by weak eye muscles.
10000030
e
Mitochondrial
QuestionChoice
Cystic fibrosis is an autosomal recessive disease. An example of an x-linked dominant disorder would be Fragile X syndrome resulting in issues with brain development.
10000029
d
X-linked dominant
Concept
Chapter
2693
3698
Cystic Fibrosis
Topic
132
Respiratory
12552
What is the inheritance pattern of cystic fibrosis?
a