QuestionSBA
QuestionChoice
This happens when a T cell has MHCI positive selection, not MHCII positive selection. These cells have no affinity for self-peptides.
10023483
d
CD8+ cells are released into the periphery
QuestionChoice
This occurs if a T cell has MHCII positive selection, however, these cells have no affinity for self-peptides. This means that they won't get activated in the periphery against our own cells and potentially cause an autoimmune disease.
10023481
b
CD4+ cells are released into the periphery
QuestionChoice
If a T cell has MHCII positive selection, then it becomes a CD4+ cell. If there is also a low affinity for a self-peptide, this cell becomes a natural T reg cell. T reg cells have upregulated CD25.
10023480
a
CD4+ cells become natural T-reg cells
QuestionChoice
This happens when a T cell has MHCI positive selection, not MHCII positive selection, and also has a high affinity for self-peptides.
10023484
e
CD8+ cells undergo apoptosis
QuestionChoice
This happens if a T cell has MHCII positive selection but has a very strong affinity for self-peptides. If this cell gets into the periphery, it will bind to self-cells, causing inflammation and damage. This is why it gets apoptosed.
10023482
c
CD4+ cells undergo apoptosis
Concept
Chapter
2693
4144
T cell maturation
Topic
158
Immunology
17094
During T cell maturation, what happens if there is MHCII positive selection and a low affinity for negative selection?
a