QuestionSBA
QuestionChoice
Gliclazide is usually taken life-long
34086
b
Gliclazide can only be used for short-term treatment to prevent long-term side effects
QuestionChoice
Gliclazide can cause weight gain by increasing the concentration of insulin, which is an anabolic hormone that promotes fat storage
34089
e
Gliclazide may cause weight loss
QuestionChoice
Gliclazide can sometimes lead to hypoglycaemia due to the increase in insulin synthesis. Hence, patients are advised to avoid missing meals and to carry a source of sugar with them at all times
34085
a
He should avoid missing meals to prevent low blood sugar from happening
QuestionChoice
If a dose of gliclazide is missed, patients are advised to take the next dose at the usual time. Patients should not take a double dose to make up for the forgotten dose
34088
d
If he has forgotten to take gliclazide the day before, he should take a double dose to make up for the forgotten dose
QuestionChoice
Gliclazide is a sulfonylurea that increases the amount of insulin produced by the body
34087
c
Gliclazide is a biguanide that decreases glucose production by liver
Concept
Chapter
#### Monitoring

The BNF advises to monitor lung function (in patients with a history of obstructive airway disease).

#### Overdoses

Overdosages with beta-blockers may cause cardiac effects such as bradycardia, hypotension, syncope, conduction abnormalities, and heart failure. Bradycardia is the most common arrhythmia, but some beta-blockers may induce ventricular tachyarrhythmias secondary to prolongation of QT interval (e.g. sotalol) or QRS duration (e.g. propranolol).
Non-cardiovascular effects include central nervous system effects (including drowsiness, confusion, convulsions, hallucinations, and in severe cases coma), respiratory depression, and bronchospasm.

Management
 - Airway protection 
 - Activated charcoal within 1 hour
 - IV Fluids
 
IV glucagon is the first-line management.
 
For symptomatic bradycardia, IV atropine may be used.

2618
2761
Gliclazide
Topic
9
Internal Medicine
6828
Case presentation: A 55-year-old man attends the diabetes clinic for review of his diabetic medication. He still complains of thirst and frequent urination despite the up-titration of his metformin dose 3 months ago.  

PMH: Type 2 Diabetes Mellitus, Hypertension
DH: Metformin hydrochloride 1g PO BD, Captopril 50mg PO BD
Investigations: HbA1c 65 mmol/mol (20-42)
The patient is advised to add a new prescription of gliclazide 40mg PO daily to his current treatment regime.

Question: Select the most important information that should be provided for this patient.
a