QuestionSBA
QuestionChoice
This is the mechanism of action of dipyridamole, which inhibits the attachment of platelets to the endothelium. This in turn inhibits platelet aggregation. It does not describe the mechanism of action of clopidogrel.
10008132
c
Phosphodiesterase inhibitor
QuestionChoice
This is the mechanism of action of aspirin. Aspirin inhibits COX-1 mediated production of thromboxane A2 (TXA2) and reduces platelet aggregation. It does not describe the mechanism of action of clopidogrel.
10008131
b
Cyclo-oxygenase inhibitor
QuestionChoice
This is the mechanism of action of direct-acting anticoagulants (DOACs) such as apixaban. It does not describe the mechanism of action of clopidogrel.
10008134
e
Factor Xa inhibition
QuestionChoice
This is the mechanism of action of abciximab. It blocks the binding of fibrinogen and von Willebrand factor, hence inhibiting platelet aggregation. It does not describe the mechanism of action of clopidogrel.
10008133
d
Glycoprotein IIb/IIIa inhibitors
QuestionChoice
Clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor, therefore inhibiting the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. This in turn reduces platelet aggregation.
10008130
a
ADP receptor antagonist
Concept
Chapter
2693
3713
Myocardial infarction and Acute Coronary Syndrome (ACS)
Topic
134
Cardiology
14173
A 55-year-old male is admitted to the emergency department with central chest pain. His ECG demonstrates ST-segment elevation, and he is diagnosed with a myocardial infarction (MI). He requires antiplatelet therapy for the prevention of a second MI, however unfortunately has a known sensitivity to aspirin. His doctor, therefore, prescribes clopidogrel as an alternative.

Which of the following describes the mechanism of action of clopidogrel?
a