QuestionSBA
QuestionChoice
Pheochromocytoma is a rare adrenal gland tumour that can lead to the overproduction of catecholamines, epinephrine and norepinephrine. Catecholamines originate from the adrenal medulla, not the zona glomerulosa of the adrenal cortex. This option is therefore incorrect.
10025373
d
Pheochromocytoma
QuestionChoice
Addison's disease is characterised by adrenal insufficiency, resulting in low levels of cortisol and aldosterone. Similarly, hypotension and hyperkalaemia are most commonly seen in Addison's disease, whereas the opposite is true in this case. The high aldosterone/renin ratio further supports a diagnosis of Conn's syndrome.
10025371
b
Addison's disease
QuestionChoice
This is the correct answer. Conn's syndrome, also known as primary hyperaldosteronism, is a condition characterised by the overproduction of aldosterone, primarily originating from the zona glomerulosa. Aldosterone plays a crucial role in regulating sodium and potassium balance in the body. Excess aldosterone can lead to hypertension and low potassium levels.
10025370
a
Conn's syndrome
QuestionChoice
CAH is characterised by enzyme deficiencies in the adrenal glands, leading to excessive production of androgens and, in some cases, mineralocorticoids. Androgens are produced in the zona reticularis of the adrenal cortex, while aldosterone is produced in the zona glomerulosa. This option is therefore incorrect.
10025374
e
Congenital Adrenal Hyperplasia (CAH)
QuestionChoice
Cushing's syndrome involves the overproduction of cortisol, leading to symptoms such as weight gain, high blood pressure, and easy bruising. It is commonly associated with hypotension and hyperkalaemia, thus making Cushing's syndrome an unlikely diagnosis in this case.
10025372
c
Cushing's syndrome
Concept
Chapter
2693
5834
Mineralocorticoid excess
Topic
133
Endocrinology
17472
A 21 year old female is investigated by her GP for treatment-resistant hypertension. She reports a healthy diet and active lifestyle, and reports drinking lots of water. She notes feeling more tired than usual for the past 6 months, and has frequent headaches, but can work full time as a shop assistant.

She undergoes a range of blood tests, which find an elevated aldosterone/renin ratio as well as a mild hypokalaemia. The clinician explains there is an overproduction of a hormone produced by the zona glomerulosa of the adrenal cortex.

Which of the following it the most likely underlying diagnosis?
a