QuestionSBA
QuestionChoice
This is correct. Fibroblast growth factor (FGF) is a molecule that is vital towards the growth of the limbs. Achondroplasia results from a mutation in one of the receptors for FGF hence inhibiting the function of FGF.
10004326
a
FGF (fibroblast growth factor)
QuestionChoice
This is incorrect. MyoD is involved in regulating myogenesis and regulating muscle repair.
10004327
b
MyoD
QuestionChoice
This is incorrect. Wnt regulates a range of cellular processes such as cell fate determination, primary axis formation and organogenesis.
10004329
d
Wnt
QuestionChoice
This is incorrect. Shh plays a role in cell growth and patterning of the body. Whilst it does play a role in limb development by controlling the width of the limb bud, FGF (fibroblast growth factor) is the molecule that determines the verticle growth of the limb.
10004330
e
Shh (Sonic Hedgehog)
QuestionChoice
This is incorrect. IGF-1 is the major mediator of growth hormone which promotes the normal growth of bones and tissues. Achondroplasia results from incorrect signalling of FGF which initiates the growth of limbs.
10004328
c
IGF-1 (insulin-like growth factor)
Concept
Chapter
2693
4267
Defects in growth
Topic
190
Musculoskeletal
13412
Achondroplasia is due to incorrect signalling of which of the following molecules?
a