QuestionSBA
QuestionChoice
These antibodies are more likely to be present in primary hyperthyroidism caused by Graves disease. Hypothyroidism is more likely to detect anti-thyroid peroxidase antibodies. However, some patients will not have this autoantibody even if they have primary hypothyroidism.
10000839
d
Presence of thyroid-stimulating hormone receptor antibodies
QuestionChoice
Reduced TSH and reduced fT4 suggest there is a problem higher up in the thyroid axis, in the hypothalamus or pituitary, that has caused reduced fT4. This is consistent with secondary hypothyroidism.
10000840
e
Reduced thyroid-stimulating hormone, reduced fT4
QuestionChoice
Reduced fT4 is responsible for the symptoms of hypothyroidism. Lack of negative feedback on the pituitary gland releases TSH into circulation. Thyroid-stimulating hormone (TSH) is the best biomarker for thyroid status.
10000836
a
Raised thyroid-stimulating hormone and reduced free T4
QuestionChoice
Raised fT4 will cause symptoms of hyperthyroidism (sweating, agitation, tachycardia, weight loss). This will feedback to the pituitary gland to release less TSH. fT3 is used to diagnose hyperthyroidism, as well as TSH and fT4.
10000837
b
Reduced thyroid-stimulating hormone, and raised free T4 and T3
QuestionChoice
In primary hypothyroidism, both of these hormones would be raised due to the lack of negative feedback provided by reduced levels of fT4.
10000838
c
Reduced thyrotropin-releasing hormone and raised thyroid-stimulating hormone
Concept
Chapter
2693
3834
Thyroid Axis
Topic
167
Endocrine physiology
12714
A patient presents to the GP with fatigue, weight gain and cold intolerance. The GP tests their thyroid status for the first time.

Which test results indicate primary hypothyroidism?
a