QuestionSBA
QuestionChoice
This is incorrect. Warfarin doesn't enhance fibrinolysis but instead works by inhibiting the synthesis of vitamin K-dependent clotting factors (Factors II, VII, IX, and X), which are essential for blood coagulation.
10026068
d
Enhancement of fibrinolysis
QuestionChoice
This is incorrect. Warfarin works by inhibiting the synthesis of vitamin K-dependent clotting factors (Factors II, VII, IX, and X), which are essential for blood coagulation. Fibrinolysis is a process whereby clots are broken down. Inhibiting this process would therefore increase the tendency of the blood to clot, rather than work as an anticoagulant.
10026069
e
Inhibition of fibrinolysis
QuestionChoice
This is incorrect. While warfarin does indirectly affect thrombin production through its impact on clotting factors, it doesn't directly inhibit thrombin production. It inhibits vitamin K-dependent clotting factors. By contrast, dabigatran inhibits the action of thrombin, thus preventing the conversion of fibrinogen to fibrin.
10026067
c
Inhibition of thrombin production
QuestionChoice
Correct. Warfarin works by inhibiting the synthesis of vitamin K-dependent clotting factors (Factors II, VII, IX, and X), which are essential for blood coagulation. This is the primary mechanism of action of warfarin.
10026065
a
Inhibition of vitamin-K-dependent clotting factors
QuestionChoice
This is incorrect. Warfarin primarily affects the coagulation cascade by inhibiting the production of vitamin K-dependent clotting factors, rather than by preventing platelet aggregation.
10026066
b
Inhibition of platelet aggregation
Concept
Chapter
2693
4115
Warfarin
Topic
203
Pharmacology of Haemostasis and Thrombosis
17611
A 68 year old male is diagnosed with aortic stenosis and undergoes a mechanical aortic valve replacement. Following the surgery, he is prescribed warfarin.

Which of the following describes the primary mechanism of action of warfarin?
a