QuestionMultiA
QuestionChoice
33818
a
Labetalol;80mg;hourly;intravenous (IV)
QuestionChoice
33822
e
Levothyroxine sodium;100mg;Daily;oral (PO)
QuestionChoice
33820
c
Carbamazepine;100mg;12-hourly;oral (PO)
QuestionChoice
33821
d
Gabapentin;300mg;8-hourly;oral (PO)
QuestionChoice
33824
g
Metformin;1g; Daily;oral (PO)
QuestionChoice
33819
b
Fluoxetine;20mg;Daily;oral (PO)
QuestionChoice
33823
f
Aspirin;75mg;Daily;oral (PO)
QuestionComment
i mean the gabapentin is frequency not known on the bnf so this is just a shit question, better off putting just two options 
40293
QuestionComment
The BNF often has 'frequency not known' even for potentially well known side effects. This usually when the drugs are quite old and didnt have the same testing requirements as today.
44050
User
subscriber
Amnesia Syndrome
User
subscriber
HarryDM
Concept
Chapter
#### Monitoring

The BNF advises to monitor lung function (in patients with a history of obstructive airway disease).

#### Overdoses

Overdosages with beta-blockers may cause cardiac effects such as bradycardia, hypotension, syncope, conduction abnormalities, and heart failure. Bradycardia is the most common arrhythmia, but some beta-blockers may induce ventricular tachyarrhythmias secondary to prolongation of QT interval (e.g. sotalol) or QRS duration (e.g. propranolol).
Non-cardiovascular effects include central nervous system effects (including drowsiness, confusion, convulsions, hallucinations, and in severe cases coma), respiratory depression, and bronchospasm.

Management
 - Airway protection 
 - Activated charcoal within 1 hour
 - IV Fluids
 
IV glucagon is the first-line management.
 
For symptomatic bradycardia, IV atropine may be used.

2618
2716
Dosing error & drugs causing hyponatraemia
Topic
76
Obstetrics and Gynaecology
1. Hyponatremia is a recognised complication of selective serotonin re-uptake inhibitors (fluoxetine), carbamazepine and gabapentin, via syndrome of inappropriate antidiuretic hormone secretion (SIADH).
2. Maintenance dose of levothyroxine sodium is prescribed as 100-200 micrograms daily, not milligrams.
6783
b c d
e
Case presentation: A 22-week pregnant woman who is 30 years old is admitted to the emergency department with suspected pre-eclampsia. PH Type 2 Diabetes mellitus, Epilepsy, Depression, Hashimoto’s Disease. DH Her current regular medications are listed (below).




 **On Examination**
Abdominal tenderness, bilateral swelling of ankles.


 **Investigation**
BP 145/95 mmHg. Na 120 mmol/L (135-145) Urine dipstick ++ protein


Question 1: Select the THREE prescriptions that are most likely to be contributing to her hyponatremia (mark them with a tick in column A)
Question 2: Select the ONE prescription that contains a serious dosing error (mark it with a tick in column B).