QuestionSBA
QuestionChoice
This is the mechanism of action of warfarin, an oral anticoagulant used as first-line management of VTE for many years, before being surpassed by the use of direct oral anticoagulants (DOACs). Nowadays, warfarin use is indicated in patients with mechanical heart valves and as a second line after DOACs. This does not describe the mechanism of action of LMWH, which activates antithrombin 3.
10007525
e
Inhibits epoxide reductase
QuestionChoice
This describes the mechanism of action of statins, not low molecular weight heparin. HMG-CoA reductase is the enzyme involved in hepatic cholesterol synthesis, which reduces the production of low-density lipoprotein (LDL) cholesterol In the blood. This does not describe the mechanism of action of LMWH, which activates antithrombin 3.
10007522
b
Inhibit HMG-CoA reductase
QuestionChoice
This describes the mechanism of clopidogrel, an antiplatelet agent used in the management of cardiovascular disease. This does not describe the mechanism of action of LMWH, which activates antithrombin 3.
10007524
d
Antagonist of ADP receptor
QuestionChoice
This is the mechanism of action of isoniazid, a drug given for tuberculosis. This does not describe the mechanism of action of LMWH, which activates antithrombin 3.
10007523
c
Inhibits mycolic acid synthesis
QuestionChoice
This is the correct answer. LMWH activates antithrombin III, and then forms a complex that inhibits factor Xa. This brings about an anticoagulant effect. This means that LMWH can be monitored through anti-factor Xa, although routine monitoring is not usually required.
10007521
a
Activates antithrombin 3
Concept
Chapter
2693
4608
Low molecular weight heparin
Topic
203
Pharmacology of Haemostasis and Thrombosis
14051
A 30-year-old pregnant woman attends the emergency department with left leg pain and swelling. An ultrasound doppler demonstrates a deep vein thrombosis. She is treated with low molecular weight heparin (LMWH).

Which of the following correctly describes the mechanism of action of LMWH?
a