QuestionSBA
QuestionChoice
Lamotrigine blocks voltage-gated Na+ channels. This prevents the depolarisation of glutamatergic neurones and reduces glutamate neurotoxicity.
10002237
a
It blocks voltage-gated Na+ channels, preventing Na+ influx
QuestionChoice
This is the mechanism of action of sodium valproate. Through this mechanism, it increases GABA concentrations in synapses and prolongs GABA action within synapses.
10002238
b
It inhibits GABA transaminase, preventing the breakdown of GABA
QuestionChoice
This is the mechanism of action of an SSRI, or selective serotonin reuptake inhibitor. This is not an anti-epileptic drug and is instead used in the treatment of depression.
10002241
e
It inhibits the reuptake of serotonin, thereby increasing serotonin activity
QuestionChoice
This is the mechanism of action of diazepam. Here, increased chloride ion influx is associated with the hyperpolarisation of excitatory neurones.
10002239
c
It increases chloride ion influx in response to GABA binding at the GABA A receptor
QuestionChoice
This is the mechanism of action of levetiracetam. Levetiracetam inhibits this protein and prevents vesicle exocytosis. A reduction in glutamate secretion reduces glutamate excitotoxicity.
10002240
d
It inhibits the synaptic vesicle protein SV2A
Concept
Chapter
2693
4023
Pharmacokinetics of anti-epileptics
Topic
172
Pharmacology of the Nervous System
12994
What is the mechanism of action of lamotrigine?
a