QuestionSBA
QuestionChoice
These features are seen in acute promyelocytic leukaemia, a subtype of acute myeloid leukaemia, which has a good prognosis. CML is commonly seen in older patients and features a different genetic hallmark.
10004678
c
Disseminated intravascular coagulation, Auer rods, young age, PML/RARa gene fusion
QuestionChoice
These are features of myeloma, a neoplastic proliferation of monoclonal plasma cells in the bone marrow.
10004679
d
Hypercalcaemia, renal insufficiency, normochromic normocytic anaemia, bone lesions, high free light chains in serum
QuestionChoice
The Philadelphia chromosome is a short chromosome 22 containing an abnormal BCR-ABL fusion gene. This is identified by FISH or PCR performed following bone marrow aspiration. The presence of the Philadelphia chromosome is the Gold standard of CML diagnosis and is seen in nearly all cases. Splenomegaly, leucocytosis and severe normochromic normocytic anaemia are also features of CML.
10004676
a
Splenomegaly, leucocytosis, severe normochromic normocytic anaemia, presence of Philadelphia chromosome
QuestionChoice
These are features of Hodgkin lymphoma, a malignant proliferation of lymphocytes. The pathological hallmark of Hodgkin lymphoma is the Reed-Sternberg cell, a giant, multinucleate cell.
10004680
e
Reed-Sternberg cells, lymphadenopathy, weight loss, splenomegaly
QuestionChoice
These are general symptoms often seen in haematological malignancy, but would not point to a diagnosis of CML specifically.
10004677
b
Anaemia, splenomegaly, thrombocytopenia, lymphadenopathy, weight loss
Concept
Chapter
2693
4317
Haematological malignancies
Topic
193
Haematological Science
13482
Which set of findings would most likely point to a diagnosis of chronic myeloid leukaemia?
a