QuestionSBA
QuestionChoice
Ibuprofen does not commonly cause thrombocytopenia
34219
e
Ibuprofen 400mg PO PRN
QuestionChoice
LMWH (Dalteparin sodium) is common or very commonly associated with immune-mediated, drug induced thrombocytopenia. Heparin, which is negatively charged binds to platelet factor 4 (PF4), a positively charged molecule that is released into the circulation upon the activation of platelets. This heparin-PF4 complex acts as a immunogen, which leads to antibody production and the activation and aggregation of platelets. The clearance of the activated platelets can then lead to thrombocytopenia
34215
a
Dalteparin sodium 2500 units SC OD
QuestionChoice
Furosemide does not commonly cause thrombocytopenia
34218
d
Furosemide 40mg PO OD
QuestionChoice
Metformin does not commonly cause thrombocytopenia
34216
b
Metformin 1g BD PO
QuestionChoice
Gliclazide does not commonly cause thrombocytopenia
34217
c
Gliclazide 30mg PO OD
QuestionComment
i selected dalteparin and it changed my answer to gliclazide so i got it wrong...
39528
User
subscriber
Vaccine Ketone
Concept
Chapter
#### Monitoring

The BNF advises to monitor lung function (in patients with a history of obstructive airway disease).

#### Overdoses

Overdosages with beta-blockers may cause cardiac effects such as bradycardia, hypotension, syncope, conduction abnormalities, and heart failure. Bradycardia is the most common arrhythmia, but some beta-blockers may induce ventricular tachyarrhythmias secondary to prolongation of QT interval (e.g. sotalol) or QRS duration (e.g. propranolol).
Non-cardiovascular effects include central nervous system effects (including drowsiness, confusion, convulsions, hallucinations, and in severe cases coma), respiratory depression, and bronchospasm.

Management
 - Airway protection 
 - Activated charcoal within 1 hour
 - IV Fluids
 
IV glucagon is the first-line management.
 
For symptomatic bradycardia, IV atropine may be used.

2618
2786
Dalteparin side effects
Topic
13
Neurosurgery
6854
Case Presentation: A 45-year-old man is recovering on the gastroenterology unit following an elective pan proctocolectomy for his UC five days ago. PMH Type 2 diabetes mellitus, Resistant hypertension, Migraine. DH His current regular medicines are listed (below).


Investigation
Platelet 100 x 109/L (150-400)


Question: Select the prescription that is most likely to contribute to his thrombocytopenia.
a