QuestionSBA
QuestionChoice
High interstitial pressure within the tumour forms a barrier to transcapillary transport. This can result in a barrier to inefficient uptake of therapeutic agents by the tumour.

Therefore lower pressures may allow better delivery of cancer-targeted medications.
10005859
d
Low Interstitial Fluid Pressure within Extracellular matrix
QuestionChoice
When this receptor is present, it means that the tumour can be targeted with anti-oestrogen therapy to slow down the tumour growth.

This is a target for treatment and can improve prognostic outcomes
10005857
b
Oestrogen Receptor positive
QuestionChoice
cancer-associated fibroblasts are similar to those involved in the tissue repair process.

They play a role in maintaining the extra-cellular matrix of a tumour by remodelling and depositing cells.

They communicate with cells nearby and promote invasion and metastases. They also play a role in angiogenesis and immune cell recruitment.

Therefore, the presence of these cells is associated with poor prognosis.
10005858
c
Absence of cancer-associated fibroblasts
QuestionChoice
The tumour can recruit immune cells and block the CD8 T cells from proliferating and attacking the tumour.

Correlates with a poor prognosis.
10005856
a
Tumour Associated macrophages
QuestionChoice
Cancers with this receptor are associated with being faster growing but can be better targeted with drug treatments and can respond well and improve prognosis.
10005860
e
Presence of epidermal growth receptors
Concept
Chapter
2693
3958
Cancer pathology
Topic
182
Cancer Biology
13718
71 year old female is asking about the prognosis after receiving a diagnosis of colon cancer.

A combination of analytical tests is performed on the tissue biopsy to examine the tumour microenvironment and see what receptors are present within the tumour.

Which of these correlates with a poor prognosis of cancer?
a