QuestionSBA
QuestionChoice
This is incorrect as the Th1 response is due to gliadin antigens, not gluten antigens. Tissue transglutaminases break down gluten into gliadin which then leads to the autoimmune response.
10023518
d
Th1 response happens in response to gluten antigens
QuestionChoice
This is the pathogenesis of *Clostridium difficile* infection: an opportunistic infection in which antibiotics prescribed for another infection allow *C. difficile* bacteria into the gut and cause a diarrhoeal infection.
10023519
e
Antibiotics kill off colonised bacteria allowing harmful bacteria to enter the gut
QuestionChoice
This is incorrect as it is a Th1 response that occurs due to gliadin antigens. This Th1 response causes antibodies to be released by B cells.
10023517
c
Th2 response happens in response to gliadin antigens
QuestionChoice
This is the correct answer as the first step for coeliac disease to occur is the breakdown of gluten into gliadin. This then leads to dendritic cells taking up the antigens and presenting them to Th1 cells, resulting in antibody production.
10023515
a
Tissue transglutaminases break gluten down into gliadin
QuestionChoice
This is the incorrect answer as it is the gluten that is being broken down into gliadin, not the other way around.
10023516
b
Tissue transglutaminases break down gliadin into gluten
Concept
Chapter
2693
4236
Coeliac disease
Topic
136
Gastroenterology
17101
A 26-year-old female attends the GP surgery following laboratory tests which indicate she has coeliac disease. The doctor has thought about the mechanism by which this diagnosis has occurred.

Which of the following is a step in the pathogenesis of coeliac disease?
a