QuestionSBA
QuestionChoice
It is recommended to measure liver function prior to and at 4-6 weeks after starting this drug as terbinafine is known to be hepatotoxic
34372
c
No routine monitoring is required
QuestionChoice
It is recommended that the dose of terbinafine should be reduced in patients with renal impairment, but routine monitoring of renal function is not necessary
34374
e
Serum creatinine
QuestionChoice
This is not a necessary monitoring requirement for this drug
34371
b
Fasting lipid profile
QuestionChoice
It is recommended to measure liver function prior to and at 4-6 weeks after starting this drug as terbinafine is known to be hepatotoxic
34370
a
Liver function tests
QuestionChoice
This is not a necessary monitoring requirement for this drug
34373
d
Platelet count
Concept
Chapter
#### Monitoring

The BNF advises to monitor lung function (in patients with a history of obstructive airway disease).

#### Overdoses

Overdosages with beta-blockers may cause cardiac effects such as bradycardia, hypotension, syncope, conduction abnormalities, and heart failure. Bradycardia is the most common arrhythmia, but some beta-blockers may induce ventricular tachyarrhythmias secondary to prolongation of QT interval (e.g. sotalol) or QRS duration (e.g. propranolol).
Non-cardiovascular effects include central nervous system effects (including drowsiness, confusion, convulsions, hallucinations, and in severe cases coma), respiratory depression, and bronchospasm.

Management
 - Airway protection 
 - Activated charcoal within 1 hour
 - IV Fluids
 
IV glucagon is the first-line management.
 
For symptomatic bradycardia, IV atropine may be used.

2618
2817
Terbinafine side effects
Topic
74
Elderly Care
6885
Case Presentation: An 88 year old woman attends a follow-up appointment for review at her GP. One month ago she was seen in the outpatient dermatology clinic for a surgical excision of a basal cell carcinoma. She was incidentally diagnosed at the time with multiple-nail onychomycosis on her left foot and started on terbinafine 250mg PO OD.


Question: Select the most appropriate option to monitor for adverse effects of this treatment.
a