QuestionSBA
QuestionChoice
Switching on telomerase enables replicative immortality of the cell, preventing senescence and telomere shortening. Whilst this is key in cancer, it is unrelated to evading growth suppression.
10006998
c
Switching on telomerase
QuestionChoice
Inactivation of the p53 tumour suppressor gene is a frequent event in tumorigenesis. Usually, the p53 gene plays a role in controlling cell division and cell death. Inactivation of this gene removes one of the protective factors in cancer development by allowing cancer cells to be unsuppressed. It can occur by various cellular stresses such as hypoxia and DNA damage.
10006996
a
Inactivation of tumour protein p53 (TP53)
QuestionChoice
Induction of vascular endothelial growth factor (VEGF) allows for induction of angiogenesis, which is another hallmark of cancer but unrelated to evading growth suppression.
10006997
b
Induction of vascular endothelial growth factor (VEGF)
QuestionChoice
Secretion of TGF-β allows cells to avoid immune destruction and proliferate with greater freedom. Whilst this is key in cancer, it is unrelated to evading growth suppression.
10006999
d
Secretion of transforming growth factor beta (TGF-β)
QuestionChoice
Production of IGF survival factor allows cancer cells to resist planned cell death and continue to proliferate. Whilst this is key in cancer, it is unrelated to evading growth suppression.
10007000
e
Production of Insulin-like growth factor survival factor
Concept
Chapter
2693
3958
Cancer pathology
Topic
182
Cancer Biology
13946
A 61-year-old man has recently been diagnosed with colorectal cancer. He asks his doctor for more information.

Which of the following mechanisms allows cancer cells to evade growth suppression?
a