QuestionSBA
QuestionChoice
This is correct. ACE-inhibitors, as the name suggests, inhibit the enzyme angiotensin-converting enzyme (ACE), which plays a crucial role in converting angiotensin I into angiotensin II. Angiotensin II is a potent vasoconstrictor. By inhibiting its production, ACE inhibitors reduce vasoconstriction and ultimately lower blood pressure.
10026080
a
Inhibition of angiotensin II production
QuestionChoice
This is incorrect. While ACE inhibitors can indirectly affect aldosterone levels, their primary mechanism of action is related to angiotensin II inhibition, not aldosterone suppression. Reduced aldosterone levels are a secondary effect of ACE inhibitors.
10026082
c
Inhibition of aldosterone secretion
QuestionChoice
This is incorrect. ACE inhibitors do not inhibit nitric oxide production; in fact, they may increase nitric oxide levels. Nitric oxide is a vasodilator, which means it helps relax blood vessels, leading to lower blood pressure.
10026084
e
Inhibition of nitric oxide production
QuestionChoice
This is incorrect. ACE inhibitors do the opposite and actually reduce angiotensin II levels, leading to a decrease in the stimulation of angiotensin II receptors.
10026081
b
Stimulation of angiotensin II receptor
QuestionChoice
This is incorrect. ACE inhibitors do not stimulate the sympathetic nervous system. They typically have a mild inhibitory effect on the sympathetic nervous system, which helps lower blood pressure.
10026083
d
Stimulation of the sympathetic nervous system
Concept
Chapter
2693
4614
ACE-inhibitors
Topic
188
Renal Pharmacology
17614
A 61 year old white male with type 2 diabetes visits his General Practitioner for an annual health check. His blood pressure is measured at 154/100.  The reading from his previous appointment is 146/97. The GP diagnoses him with hypertension and prescribes ramipril, an angiotensin-converting enzyme inhibitor (ACE-inhibitor).

By which of the following mechanisms do ACE inhibitors lower blood pressure?
a