QuestionSBA
QuestionChoice
This pathway connects the substantia nigra to the mid-striatum. It is involved in associative functions, for example, learning, habituation, memory, attention, motivation, emotion, and volition. D2 receptor antagonism in the associative striatum reduces the positive symptoms that occur during psychosis.
10026589
e
Nigrostriatal associative pathway
QuestionChoice
The tuberoinfundibular pathway connects the hypothalamus to the pituitary gland (tuberal region to the infundibular region at the top of the pituitary stalk). It plays a role in regulating the release of hormones from the pituitary gland, particularly prolactin. Dopamine acts as an inhibitory signal, inhibiting the release of prolactin. D2 receptor antagonism results in hyperprolactinaemia, as the inhibitory effect of dopamine is lost.
10026588
d
Tuberoinfundibular pathway
QuestionChoice
This pathway also originates in the VTA but projects to the prefrontal cortex. It is involved in higher-order cognitive functions, including executive function, decision-making, and emotional regulation. D2 receptor antagonism may exacerbate low dopamine in this region, leading to deterioration in cognitive function.
10026587
c
Mesocortical pathway
QuestionChoice
The nigrostriatal pathway connects the substantia nigra to the dorsal striatum. It is primarily involved in motor control. Dysfunction of this pathway leads to motor symptoms such as tremors, rigidity, and bradykinesia. Anti-psychotics reduce the amount of dopamine by acting as D2 receptor antagonists. It blocks the receptors in the nigrostriatal motor pathway causing Parkinsonism and extrapyramidal side effects.
10026585
a
Nigrostriatal motor pathway
QuestionChoice
The mesolimbic pathway originates in the ventral tegmental area (VTA) and projects to various regions in the limbic system, including the nucleus accumbens, amygdala, and hippocampus. It is associated with reward, pleasure, and reinforcement. Excessive D2 receptor antagonism results in worsening of the negative symptoms.
10026586
b
Mesolimbic pathway
Concept
Chapter
2693
5900
Side-effects of antipsychotics
Topic
173
Psychiatry
17715
A 33-year-old male patient presents with symmetrical rigidity of his limbs, slowness of movement and lack of facial expression. He has a past medical history of schizophrenia and has recently been initiated on a new anti-psychotic medication.

What pathway in the dopamine system is implicated?
a