QuestionSBA
QuestionChoice
Type 4 hypersensitivity reactions are known as delayed-type hypersensitivity reactions. They involve T lymphocytes and reactions often occur 24 to 72 hours after exposure to an antigen. Examples of type 4 hypersensitivity reactions include contact dermatitis and transplant rejections.
10024984
e
Type 4
QuestionChoice
Graves' Disease is a type 5 hypersensitivity reaction. These reactions occur when antibodies bind to cell surface receptors. A further example of a type 5 hypersensitivity reaction is myasthenia gravis. Type 5 reactions are relatively new within the medical literature, and previously Graves' would have been considered a Type 2 reaction, which your university may still be teaching. If this is the case, we would advise clarifying with your university.
10024980
a
Type 5
QuestionChoice
Examples of type 3 hypersensitivity reactions include systemic lupus erythematosus, and less commonly post-streptococcal glomerulonephritis. These reactions are mediated by immune complexes.
10024981
b
Type 3
QuestionChoice
Type 2 hypersensitivity reactions include rheumatic fever and autoimmune haemolytic anaemia. These reactions take place when either IgG or IgM bind to a cell surface antigen, so are known as cell bound reactions. The patient in this question has Graves' disease, which is a type 5 hypersensitivity reaction.
10024983
d
Type 2
QuestionChoice
Type 1 hypersensitivity reactions occur when antigens bind and react to IgE immunoglobulins. Common examples of type 1 hypersensitivity reactions include anaphylaxis, asthma, eczema and hay fever.
10024982
c
Type 1
QuestionComment
bristol teaches graves disease as a type IIb hypersensitivity reaction
50727
User
subscriber
zuzu0103
Concept
Chapter
2693
4091
Hypersensitivity reactions
Topic
158
Immunology
17394
A 15-year-old male attends his GP with a six-month history of weight loss and diarrhoea. On further questioning, he is found to be sweaty and restless, and has had trouble sleeping. On examination, he has diplopia and you notice the upper eyelid is slow to descend on downgaze. The GP suspects a diagnosis of Graves' disease.

Which type of hypersensitivity reaction is Graves' disease?
a