QuestionSBA
QuestionChoice
This is the predominant antibody in a primary response to a viral or bacterial infection. It is not routinely tested for.
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c
IgM
QuestionChoice
If raised, this can indicate inflammation in the body. It can help monitor conditions with a high level of inflammation such as Inflammatory Bowel Disease and Arthritis.
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d
ESR
QuestionChoice
This can help diagnose anaphylaxis but is rarely performed as the blood test must be processed extremely quickly after collection.
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e
Histamine
QuestionChoice
This protein is released during activation of mast cells and levels will increase in anaphylaxis. Important to consider if this is the first episode of anaphylaxis as it can mimic other emergencies such as asthma.

This should be taken 1-2 hours after symptom onset and no longer than 4 hours after.

Confirms diagnosis if positive and helps to assist in correct treatment and minimisation of risk for future infections. Negative result does not exclude diagnosis.

Should be tested for in a follow-up to measure baseline.
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a
Mast cell tryptase
QuestionChoice
This antibody is found raised in blood in type 1 hypersensitivity reactions.

These include atopic diseases such as asthma, hayfever and eczema. It can also be raised allergies/anaphylaxis but is not specific to this.

However, allergen-specific IgE antibodies to an allergen such as penicillin can be tested for. A positive test only indicates sensitisation and may not indicate allergy as re-exposure does not always cause symptoms.
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b
IgE
Concept
Chapter
2693
4446
Anaphylaxis (Paediatrics)
Topic
153
Paediatrics
13697
10 year old girl presents to the emergency department pale and clammy with wheeze, severe shortness of breath and some tongue swelling. This began within an hour of recieving her first dose of penecillin for a tonsolitis.

Mother is distressed and cannot recall whether she has had penecillin before.

Anaphylaxis is suspected and 300mcg of adrenaline is given.

Which of these can be tested within 4 hours of symptom onset to confirm the diagnosis of anaphylaxis?
a