QuestionSBA
QuestionChoice
Activation of beta-2 receptors on airway smooth muscle by glucocorticoids stimulates the Gs pathway. This increases the concentration of cAMP which stimulates protein kinase A to decrease calcium mobilisation and sensitivity. This causes muscle relaxation and therefore relieves the bronchoconstriction associated with asthma.
10024330
a
Increases beta-2 receptor activation
QuestionChoice
Glucocorticoids decrease the number of mast cells. As mast cells are immune cells, this reduces the inflammatory response produced by the immune system.
10024333
d
Increases number of mast cells
QuestionChoice
Glucocorticoids reduce endothelial cell leakage. As cell leakage is part of the inflammatory response, glucocorticoids can reduce inflammation by decreasing leakage.
10024332
c
Increases endothelial cell leakage
QuestionChoice
Glucocorticoids reduce the number of dendritic cells. As dendritic cells are immune cells, this reduces the inflammatory response produced by the immune system.
10024331
b
Increases the number of dendritic cells
QuestionChoice
Glucocorticoids reduce cytokine release from T cells. Asthma is associated with the cytokines interleukin 4, 5 and 13 (IL-4, IL-5, IL-13) which promote airway eosinophilia and mucus overproduction. Therefore glucocorticoids can reduce inflammation by decreasing cytokine mediators.
10024334
e
Increases cytokine mediators of inflammation
Concept
Chapter
2693
4228
Treatment options in Asthma
Topic
189
Respiratory Pharmacology
17264
Which of the following is the mechanism of action by which glucocorticoids reduce asthmatic inflammation?
a