QuestionSBA
QuestionChoice
A double mastectomy in this instance would be an aggressive surgical approach given the cancer only being Stage-1. Instead, a more breast-conserving surgery would be preferred e.g. wide local excision. Tamoxifen is used to treat ER+ breast cancer. However, it is usually reserved for pre-menopausal women so would not be appropriate for a woman of this age.
10000513
c
Double mastectomy with adjuvant tamoxifen therapy
QuestionChoice
Wide local excision would be appropriate to remove the cancer. However, trastuzumab is a monoclonal antibody used to treat HER2+ breast cancer - so it would not be appropriate to give this unless the patient was known to be HER2+.
10000515
e
Wide local excision of the lesion with adjuvant trastuzumab (@Herceptin) therapy
QuestionChoice
Fine needle aspiration is a method of collecting cells from tumours for diagnostic purposes, it is not usually therapeutic. Hence, it would not be appropriate given that the cancer is already diagnosed and staged. However, adjuvant anastrozole would be appropriate following an excision.
10000514
d
Fine needle aspiration of the lesion with adjuvant anastrozole (@Arimidex) therapy
QuestionChoice
Whilst both surgical excision and an aromatase inhibitor (e.g. Anastrozole) are the most appropriate choice for this patient, the hormone therapy should be given as an adjuvant treatment (after the surgery) rather than as a neoadjuvant treatment (before the surgery).
10000512
b
Wide local excision of the lesion with neoadjuvant anastrozole (@Arimidex) therapy
QuestionChoice
Excision of the cancer followed by adjuvant endocrine therapy in the form of an aromatase inhibitor (e.g. anastrozole) is the first-line treatment to reduce the risk of recurrence of ER+ breast cancer. Aromatase inhibitors such as anastrozole are also first-line in post-menopausal patients with ER+ breast cancer. Therefore, given this patient's age, this would be the most appropriate treatment.
10000511
a
Wide local excision of the lesion with adjuvant anastrozole (@Arimidex) therapy
Concept
Chapter
2693
3779
Breast Cancer
Topic
151
Breast Disease
12649
A 75-year-old woman is diagnosed with Stage-1 oestrogen-receptor positive (ER+) breast cancer. She would like to proceed with treatment.

Which of the following treatments is most appropriate?
a