QuestionSBA
QuestionChoice
Low mood has a very wide differential list. However, the fact she is experiencing cold intolerance and weight gain makes hypothyroidism the most likely.
10027786
a
Hypothyroidism
QuestionChoice
The low mood and tiredness could be explained by iron deficiency anaemia, but the weight gain is not typical. Furthermore, it is likely that there would be additional features such as pallor and shortness of breath.
10027788
c
Iron deficiency anaemia
QuestionChoice
This would affect the patient in the opposite way to described. They may be losing weight and becoming intolerant to heat. They may still be fatigued.
10027789
d
Hyperthyroidism
QuestionChoice
The low mood and tiredness could be explained by anaemia, however, it is likely that there would be additional symptoms such as shortness of breath and pallor. For pernicious anaemia, in particular, there is an association with autoimmune conditions such as type 1 diabetes.
10027790
e
Pernicious anaemia
QuestionChoice
Depression is a good differential diagnosis for low mood and tiredness, however, physical health conditions need to be ruled out first as they can be managed and the low mood treated. Furthermore, the weight gain and cold intolerance are more indicative of hypothyroidism.
10027787
b
Depression
Concept
Chapter
2693
3765
Hypothyroidism
Topic
133
Endocrinology
17955
A 44-year-old woman presents to her GP with low mood. She describes feeling down and tired for a few months now. Nothing seems to have triggered this episode. She also has gained some weight in this time, but she puts this down to comfort eating. You notice that in the consulting room, she is wearing multiple layers despite it being 20 degrees outside.

What is the most likely diagnosis?
a