QuestionSBA
QuestionChoice
This is the neuropathological hallmark of multiple sclerosis, which is not associated with any of the symptoms listed in the vignette.
10004562
b
Demyelination
QuestionChoice
The features described are those of Parkinson’s disease. Although other causes (e.g. drugs) can result in similar syndromes, the most likely neuropathological finding is Lewy bodies.
10004561
a
Lewy bodies
QuestionChoice
These are spherical inclusions in neuronal cytoplasm, found in behavioural variant frontotemporal dementia. This disease has clinical features including disinhibition, apathy and loss of executive dysfunction.
10004565
e
Pick bodies
QuestionChoice
These can be found in some Parkinson’s plus syndromes such as progressive supranuclear palsy (PSP), as well as Alzheimer’s disease. PSP results in postural instability and rigidity, vertical gaze palsy and little tremor. Alzheimer’s disease characteristically results in cognitive impairment and episodic memory loss.
10004563
c
Tau neurofibrillary tangles
QuestionChoice
These are characteristics of Alzheimer’s disease, which has clinical features of cognitive impairment and episodic memory loss.
10004564
d
Amyloid-beta plaques
Concept
Chapter
2693
3747
Parkinson's Disease
Topic
141
Neurology
13459
An 81-year-old male presents to the GP with a ‘pill-rolling’ tremor at rest, ‘cogwheel’ rigidity and a shuffling gait with a stooped posture.

Which of the following is the most likely histopathological finding on a biopsy of the brain?
a