QuestionSBA
QuestionChoice
Exposure of tubular cells to cisplatin activates signalling pathways that are cell death-promoting (p53, and reactive oxygen species).
10001650
d
Cisplatin
QuestionChoice
ACEis are renoprotective in CKD. The renoprotective mechanism of ACEis is that they reduce systemic vascular resistance in patients with hypertension, heart failure or chronic renal disease.
10001647
a
Angiotensin-converting enzyme inhibitors (ACEis)
QuestionChoice
NSAIDs are nephrotoxic as they constrict the afferent arteriole, thus reducing blood flow to the kidney.
10001648
b
NSAIDs
QuestionChoice
The most commonly described mechanism of MTX nephrotoxicity is the crystallization of MTX in the renal tubular lumen. Other mechanisms have also been proposed such as constriction of the afferent capillary and direct effects on the mesangial or tubular epithelial cells.
10001651
e
Methotrexate (MTX)
QuestionChoice
Gentamicin induces nephrotoxicity by inhibiting protein synthesis in renal cells that specifically causes necrosis of cells in the renal proximal tubule, resulting in acute tubular necrosis, followed by acute renal failure.
10001649
c
Gentamicin
Concept
Chapter
2693
3955
Chronic kidney disease (CKD)
Topic
168
Renal Physiology
12876
Which of the following drugs are renoprotective in CKD?
a