QuestionSBA
QuestionChoice
Osteoprogenitor cells do not produce the bone extracellular matrix. Osteoprogenitor cells give rise to osteoblasts, which form bone tissue. Osteoblasts can further mature into osteocytes, which maintain bone tissue.
10003784
d
Osteoprogenitor cell
QuestionChoice
An osteon is also called a Haversion system. It is the structural and functional unit of compact bone. It consists of Type 1 collagen fibres arranged in concentric lamellae around a Haversian canal which contains blood vessels and nerves.
10003785
e
Osteon
QuestionChoice
Osteoclasts are responsible for the resorption of bone, not the formation of bone. They do this by releasing enzymes such as collagenases. Osteoclasts are large multinucleated cells, derived from monocytes.
10003782
b
Osteoclast
QuestionChoice
Osteoid is not a cell but is an unmineralised bone produced by osteoblasts. Osteoid consists of Type 1 collagen and a glycosaminoglycan gel which contains glycoproteins that bind calcium.
10003783
c
Osteoid
QuestionChoice
Osteoblasts produce osteoid and release matrix vesicles. Osteoid consists of Type 1 collagen and a glycosaminoglycan gel which contains glycoproteins that bind calcium. Matrix vesicles contain enzymes such as alkaline phosphatase which increase local concentrations of calcium.
10003781
a
Osteoblast
Concept
Chapter
2693
4201
Osteoblasts
Topic
154
Musculoskeletal physiology and disease
13303
A 52-year-old male attends fracture clinic after fracturing his wrist. When questioned, he admits to having an 8-month history of pain in his bones prior to this recent fracture. The consultant orders further investigations and he is noted to have a raised alkaline phosphatase and changes to the bone on x-ray.

He is diagnosed with Paget's disease of bone. This condition is associated with increased bone resorption, formation, and remodelling.

Which of the following is responsible for producing bone extracellular matrix?
a