QuestionSBA
QuestionChoice
This is the action of oncoprotein E7. E6 inactivates tumour suppressor gene p53 by leading to its proteosomal degradation.
10004663
c
The HPV oncoprotein E6 inactivates tumour suppressor gene pRB, allowing transcription of genes which increases the rate of the cell cycle
QuestionChoice
70% of cervical cancer cases are associated with HPV 16 and 18.
10004662
b
The majority of cervical cancer cases are associated with HPV 14 and 16
QuestionChoice
This is the action of oncoprotein E6. E7 inactivates tumour suppressor gene pRB, allowing transcription of genes which increases the rate of the cell cycle.
10004664
d
The HPV oncoprotein E7 inactivates tumour suppressor gene p53 by leading to its proteosomal degradation
QuestionChoice
HPV cannot bind to live tissue, it enters the basal cells of stratified squamous epithelium, which are exposed to micro-abrasions. The transcriptional cascade occurs as the host keratinocyte becomes increasingly differentiated in the upper layers.
10004661
a
The virus enters the basal cells of stratified squamous epithelium, which are exposed to micro-abrasions
QuestionChoice
HPV is not cytolytic. Newly-created viral particles spread as they are released from the degeneration of desquamating cells.
10004665
e
Once it has replicated inside the host cell, HPV causes cell lysis, allowing the release of virus particles and further spread
Concept
Chapter
2693
3958
Cancer pathology
Topic
182
Cancer Biology
13479
Which statement correctly describes an aspect of how the human papillomavirus (HPV) can cause cervical cancer?
a