QuestionSBA
QuestionChoice
The most likely diagnosis is sickle cell anaemia, a disease of red blood cells caused by an autosomal-recessive single gene defect in the beta chain of haemoglobin. It is most common in those of African, Hispanic, and Mediterranean origin. Sickled red blood cells cause symptoms of anaemia, and can clump together and obstruct blood flow, causing pain.

Sick cell anaemia is normally be picked up soon after birth, however was missed in this case due to the lack of screening in Nigeria. Based on this diagnosis, the most likely blood film finding is of sickle cells.
10008125
a
Sickle cells
QuestionChoice
Elliptocytes are an elongated oval-shaped version of red blood cells. They are usually seen in iron deficiency anaemia. They are not typically seen in sickle-cell anaemia, making this option incorrect.
10008128
d
Elliptocytes
QuestionChoice
Spherocytes are a type of red blood cell most commonly seen in hereditary haemolytic anaemia. This is most commonly seen in people of northern European descent. They are not typically seen in sickle-cell anaemia, making this option incorrect.
10008127
c
Spherocytes
QuestionChoice
Macrophages are a type of white blood cell. Levels are raised in acute infection. They are not indicative of sickle cell anaemia.
10008129
e
Macrophages
QuestionChoice
The most likely diagnosis in this case is sickle cell anaemia. Target cells are usually seen in obstructive liver disease. Although they can be seen in sickle cell anaemia and thalassemia as well, they are not always present, and not seen in very high numbers.
10008126
b
Target cells
Concept
Chapter
2693
4645
Blood film findings
Topic
157
Haematology
14172
A 5-year-old boy from Nigeria is brought to the GP by his mother as he has been reporting recurrent episodes of bone pain and abdominal pain. He is noted to be among the smallest in his class at school, and becomes very tired towards the end of the day.

The mother mentions that there is no post-natal screening for newborn babies in Nigeria therefore she is unsure whether or not he has any medical conditions.

Based on the most likely diagnosis, which of the following blood film findings are most likely to be seen?
a