QuestionSBA
QuestionChoice
A type IV hypersensitivity reaction is a delayed reaction mediated by T-cells. It is involved in contact dermatitis as well as the tuberculin skin test (Mantoux test). The reaction would typically occur 24 to 72 hours following antigen exposure.
10006968
c
Type IV hypersensitivity reaction
QuestionChoice
There is no type V hypersensitivity reaction.
10006970
e
Type V hypersensitivity reaction
QuestionChoice
Type I hypersensitivity reactions are immediate reactions mediated by IgE. These reactions are involved in allergy, anaphylaxis, and atopic disease.
10006967
b
Type I hypersensitivity reaction
QuestionChoice
Type III hypersensitivity reactions are antigen-antibody immune complex-mediated reactions, resulting in complement activation and local inflammation. This may occur in serum sickness, rheumatoid arthritis, SLE, and post-streptococcal glomerulonephritis.
10006969
d
Type III hypersensitivity reaction
QuestionChoice
This patient has Goodpasture's syndrome, characterised by the presence of anti-GBM antibodies which target the basement membrane of the glomerulus and lungs. This is a type II hypersensitivity reaction, which are IgG- or IgM-antibody-mediated immune reactions that damage normal cells and may occur over hours to days.
10006966
a
Type II hypersensitivity reaction
Concept
Chapter
2693
4091
Hypersensitivity reactions
Topic
158
Immunology
13940
A 34-year-old man presents with shortness of breath, haemoptysis, and chest pain. A urine dip also demonstrates proteinuria and microhaematuria. Blood tests reveal anaemia, with elevated urea and creatinine. Anti-GBM antibodies are identified on further testing and, subsequently, a diagnosis of Goodpasture's syndrome is made.

What type of hypersensitivity reaction is the underlying cause for this patient's presentation?
a