QuestionSBA
QuestionChoice
This is the correct answer. Agranulocytosis is a condition in which there is a severe reduction of neutrophils. Therefore, any symptoms of infection, such as high fever, sore throat, or mouth ulcers must be reported promptly, as these could be early signs of agranulocytosis. The exact mechanism by which carbimazole induces agranulocytosis is not fully understood, but it is believed to be an idiosyncratic reaction in some individuals.
10025395
a
Carbimazole has a rare side effect of agranulocytosis
QuestionChoice
Carbimazole is not administered as a one-time injection. It is usually prescribed in tablet form and taken orally. The treatment involves taking the medication over an extended period, often for several months, to manage hyperthyroidism.
10025399
e
Carbimazole is typically administered as a one-time injection for long-term management of hyperthyroidism
QuestionChoice
In pregnant women with overt hyperthyroidism, the use of anti-thyroid medications like carbimazole requires very careful consideration, and its continuation or discontinuation depends on the specific clinical circumstances. Carbimazole is known to cross the placenta and can affect the developing foetus. There is an associated risk of foetal congenital anomalies, particularly involving the development of the thyroid gland. In pregnancy, propylthiouracil is often preferred over carbimazole due to its lower risk of causing congenital anomalies.
10025396
b
Carbimazole should be continued by pregnant women with overt hyperthyroidism
QuestionChoice
Carbimazole inhibits the thyroid peroxidases (TPO) enzyme that catalyses the iodination of tyrosine residues in thyroglobulin. It also decreases the inorganic iodine uptake and concentration by thyroid cells. Eventually, it reduces both T3 and T4 levels.
10025398
d
Carbimazole functions to increase T3 and decrease T4
QuestionChoice
Carbimazole has no role in the treatment of allergies or hay fever. It is specific to thyroid-related conditions, particularly hyperthyroidism, as its mechanism of action is inhibition of thyroid peroxidases (TPO) that catalyses the iodination of tyrosine residues in thyroglobulin.
10025397
c
Carbimazole can also be used to treat seasonal allergies and hay fever
Concept
Chapter
2693
5836
Carbimazole
Topic
220
Endocrine Pharmacology
17477
A 39 year old patient has been recently diagnosed with hyperthyroidism. Her endocrinologist has prescribed her a medication called carbimazole to help manage her condition. They counsel her regarding its use.

Which of the following is true of carbimazole?
a