QuestionSBA
QuestionChoice
The question asks which is the most sensitive test (i.e. which would most likely be positive) for lupus, which is the most likely diagnosis. Anti-CCP antibodies are extremely specific for rheumatoid arthritis, rather than lupus.
10034904
c
Anti-CCP antibodies
QuestionChoice
The question asks which is the most sensitive test (i.e. which would most likely be positive) for lupus, which is the most likely diagnosis. Anti-Smith antibodies are extremely specific for lupus, however, they are not the most likely antibody to be found.
10034903
b
Anti-Smith antibodies
QuestionChoice
The question asks which is the most sensitive test (i.e. which would most likely be positive) for lupus, which is the most likely diagnosis. Anti-smooth muscle antibodies are more strongly associated with autoimmune hepatitis, rather than lupus.
10034905
d
Anti-smooth muscle antibodies
QuestionChoice
Anti-nuclear antibodies are found in around 99% of patients with lupus, which is the most likely diagnosis. The question asks which is the most **sensitive** test (i.e. which would most likely be positive), and so this is the correct answer.
10034902
a
Anti-nuclear antibodies
QuestionChoice
The question asks which is the most sensitive test (i.e. which would most likely be positive) for lupus, which is the most likely diagnosis. Anti-dsDNA antibodies are extremely specific for lupus, however, they are not the most likely antibody to be found.
10034906
e
Anti-double-stranded DNA antibodies
Concept
Chapter
2693
4036
Systemic lupus erythematosus (SLE)
Topic
146
Rheumatology
19384
Anti-nuclear antibodies (ANAs) are autoantibodies produced by the immune system that target components of the cell nucleus, such as DNA, RNA, histones, and nuclear proteins. .
A 19-year-old woman has been referred to the rheumatology clinic for investigation of polyarthralgia, recurrent mouth ulcers, and a butterfly-shaped rash on her face. She describes the symptoms developing over a few months and has a strong family history of autoimmune disorders.

Given the most likely diagnosis, which of the following autoantibodies is most likely to be positive?
a