QuestionSBA
QuestionChoice
Activation of NMDA receptors requires the binding of two co-agonists, glutamate and glycine, which bind to separate sites on the extracellular domains, allowing channel opening and ion influx.
10027205
e
Activation of NMDA receptors requires the binding of two co-agonists, glutamate and aspartate
QuestionChoice
This is the structure of G-protein coupled receptors. NMDA receptors are ligand-gated ion channels, not G-protein coupled receptors, which consist of 4 different subunits, each with 3 transmembrane domains.
10027204
d
They are monomeric receptors consisting of seven transmembrane domains
QuestionChoice
Memantine is an uncompetitive antagonist of the receptor, decreasing its action by entering the receptor channel after it has been opened, physically blocking ion influx into the postsynaptic cell.
10027203
c
Its action is enhanced by memantine, a drug used in the treatment of Alzheimer’s disease
QuestionChoice
The NDMA receptor is one of four types of ionotropic glutamate receptors, meaning that ligand binding opens a central ion pore, allowing ion influx into the postsynaptic cell.
10027202
b
It is one of two types of metabotropic glutamate receptors
QuestionChoice
In the receptors’ resting conformation, magnesium ions are tightly bound to the receptor pore, restricting activation and ion entry. With sufficiently strong depolarisation, the magnesium ion is displaced from the pore, allowing a large influx of cations into the postsynaptic cell.
10027201
a
They are blocked by magnesium ions in a voltage-dependent manner
Concept
Chapter
2693
3821
Synaptic neurotransmitter function
Topic
172
Pharmacology of the Nervous System
17838
Which statement correctly describes a feature of NMDA receptors?
a