QuestionSBA
QuestionChoice
Pyrazinamide is not known to cause urine discolouration. Side effects of Pyrazinamide include hepatitis and arthralgia.
10035484
c
Pyrazinamide
QuestionChoice
Isoniazid is not known to cause urine discolouration. A more established side effect of Isoniazid in the treatment of TB is peripheral neuropathy.
10035483
b
Isoniazid
QuestionChoice
Ethambutol is not known to cause urine discolouration. An important side effect of Ethambutol in the treatment of TB is optic neuritis.
10035485
d
Ethambutol
QuestionChoice
A well-established side effect of rifampicin is red/orange discolouration of secretions including tears, urine and semen.
10035482
a
Rifampicin
QuestionChoice
This is used to treat travellers’ diarrhoea or hepatic encephalopathy rather than TB. It is poorly absorbed and is not typically used to treat systemic infections.
10035486
e
Rifaximin
QuestionComment
anyone else not read :(
59861
QuestionComment
aahahha same 
61186
User
subscriber
Supine Serotonin
User
subscriber
Malignant Syndrome
Concept
Chapter
2693
3697
Tuberculosis
Topic
132
Respiratory
19500
Rifampicin can cause red/orange discolouration of urine and other secretions, a common and benign side effect of the medication.
A 47-year-old male complains of urine discolouration. He has recently been started on treatment for tuberculosis following a 6-month history of a chronic cough, night sweats and weight loss. When asked, he describes the urine as red/orange in colour and denies any dysuria or increased urinary frequency.

Which of the following medications is most likely to have caused this presentation?
a