QuestionSBA
QuestionChoice
This is incorrect. Acetazolamide is a carbonic anhydrase inhibitor which works by increasing Na+ excretion and hence causing diuresis. Potassium-sparing diuretics, on the other hand, work by inhibiting aldosterone. One of the functions of aldosterone is to stimulate the Na+/K+ exchanger which pumps Na+ into the filtrate and pumps K+ out of the filtrate. Spironolactone therefore reduces the activity of the Na+/K+ exchanger, reducing Na+ reabsorption and hence causing diuresis. It also reduces K+ excretion and hence is called potassium-sparing.
10026468
d
Acetazolamide
QuestionChoice
This is incorrect. Indapamide is a thiazide-like diuretic which inhibits the Na+/Cl- transporter in the distal convoluted tubule. Potassium-sparing diuretics, on the other hand, work by inhibiting aldosterone. One of the functions of aldosterone is to stimulate the Na+/K+ exchanger which pumps Na+ into the filtrate and pumps K+ out of the filtrate. Spironolactone therefore reduces the activity of the Na+/K+ exchanger, reducing Na+ reabsorption and hence causing diuresis. It also reduces K+ excretion and hence is called potassium-sparing.
10026467
c
Indapamide
QuestionChoice
This is incorrect. Hydrochlorothiazide is a thiazide diuretic which inhibits the Na+/Cl- transporter in the distal convoluted tubule. Potassium-sparing diuretics, on the other hand, work by inhibiting aldosterone. One of the functions of aldosterone is to stimulate the Na+/K+ exchanger which pumps Na+ into the filtrate and pumps K+ out of the filtrate. Spironolactone therefore reduces the activity of the Na+/K+ exchanger, reducing Na+ reabsorption and hence causing diuresis. It also reduces K+ excretion and hence is called potassium-sparing.
10026469
e
Hydrochlorothiazide
QuestionChoice
This is correct. Spironolactone is a potassium-sparing diuretic that works by inhibiting aldosterone. One of the functions of aldosterone is to stimulate the Na+/K+ exchanger which pumps Na+ into the filtrate and pumps K+ out of the filtrate. Spironolactone therefore reduces the activity of the Na+/K+ exchanger, reducing Na+ reabsorption and hence causing diuresis. It also reduces K+ excretion and hence is called potassium-sparing.
10026465
a
Spironolactone
QuestionChoice
This is incorrect. Furosemide is a loop diuretic which inhibits the Na-K-Cl cotransporter (NKCC2). This transporter causes reabsorption of Na+, K+, and Cl- and hence inhibition of it results in more K+ loss. Therefore, furosemide is not a potassium-sparing diuretic.
10026466
b
Furosemide
Concept
Chapter
2693
5894
Aldosterone antagonists
Topic
188
Renal Pharmacology
17691
Which of the following is a potassium-sparing diuretic?
a