QuestionSBA
QuestionChoice
Trimethoprim reduces folic acid synthesis. Adequate levels of folic acid are required to ensure the closure of the neural tube in embryological development in the first trimester. Therefore taking trimethoprim during this time increases the risk of neural tube defects, such as spina bifida.
10005516
a
Neural tube
QuestionChoice
Paramesonephric ducts develop into the female reproductive system. Folic acid is not important in this process.
10005517
b
Paramesonephric ducts
QuestionChoice
Mesonephric ducts develop into the male reproductive system. Folic acid is not important in this process.
10005520
e
Mesonephric ducts
QuestionChoice
The foregut forms the oesophagus, stomach, liver, gallbladder, bile ducts, pancreas and proximal duodenum. This does not depend on folic acid.
10005519
d
Foregut
QuestionChoice
The primitive heart tube is the first structure in the formation of the heart. This process is not dependent on folic acid.
10005518
c
Primitive heart tube
Concept
Chapter
2693
4417
Teratogenic drugs
Topic
222
General pharmacology
13650
A pregnant woman at eight weeks gestation rings the GP requesting antibiotics for a suspected UTI. She asks for Trimethoprim, as she had it four months ago and it worked well. Trimethoprim inhibits folic acid formation.

Which of the following structures in the foetus is at risk if she was to take it?
a