QuestionSBA
QuestionChoice
Yes, this is the correct answer. When paracetamol is in excess within the bloodstream, it exceeds the conjugating ability of the liver. Hence this leads to the build-up of the toxic metabolite known as NAPQI. NAPQI leads to further oxidative damage of cells due to the depletion of glutathione levels. N-acetylcysteine is used for the treatment of paracetamol overdose by replenishing glutathione levels, which prevents further oxidative damage.
10007890
a
N-acetyl-p-benzo-quinone imine (NAPQI) and N-acetylcysteine
QuestionChoice
No, this is not the correct answer. Although N-acetylcysteine is used in the management of paracetamol overdose, acetaminophen is an alternative name for paracetamol.
10007891
b
Acetaminophen and N-acetylcysteine
QuestionChoice
No, this is not the correct answer. Paracetamol overdose leads to an excess of toxic by-product N-acetyl-p-benzo-quinone imine (NAPQI), and is treated with N-acetylcysteine.
10007893
d
Acetaminophen and glutathione
QuestionChoice
No, this is not the correct answer. Paracetamol overdose leads to an excess of toxic by-product N-acetyl-p-benzo-quinone imine (NAPQI), and is treated with N-acetylcysteine.
10007894
e
Paracetamol conjugated with glucuronide and N-acetylcysteine
QuestionChoice
No, this is not the correct answer. Although NAPQI correctly refers to the toxic by-product of paracetamol overdose. Such overdoses are treated with N-acetylcysteine.
10007892
c
N-acetyl-p-benzo-quinone imine (NAPQI) and glutathione
Concept
Chapter
2693
4048
Paracetamol Overdose
Topic
136
Gastroenterology
14125
A 16-year-old boy present to A&E after taking more than 30 paracetamol tablets.

The A&E consultant explains that paracetamol overdose results in the build-up of a toxic metabolite leading to oxidative stress within hepatocytes. Fortunately, a treatment exists that can prevent such liver damage.

Which of the following toxic metabolites is seen in a paracetamol overdose, and which drug is used to prevent it causing hepatic damage?
a