QuestionSBA
QuestionChoice
ALL is caused by the proliferation of lymphoid precursor cells. ALL presents similarly to AML, but Auer rods are specifically associated with AML which makes it the most likely diagnosis.
10001395
d
Hodgkin's lymphoma
QuestionChoice
AML causes anaemia and thrombocytopenia as a result of myeloid blast cells infiltrating the bone marrow. It normally presents in patients over 65 with lymphadenopathy, splenomegaly, features of anaemia (e.g. palpitations and breathlessness), neutropenia and thrombocytopenia. Auer rods are a classic finding on blood film in AML.
10001392
a
Acute myeloblastic leukaemia (AML)
QuestionChoice
Myeloma is a blood disorder which occurs as a result of the proliferation of plasma cells. It presents with anaemia, acute kidney injury, hypercalcaemia and bone pain. Therefore, it does not fit the clinical picture of this patient. Furthermore, the blood film in multiple myeloma would show rouleaux formation.
10001396
e
Multiple myeloma
QuestionChoice
ALL is caused by the proliferation of lymphoid precursor cells. ALL presents similarly to AML, but Auer rods are specifically associated with AML which makes it the most likely diagnosis.
10001393
b
Acute lymphoblastic leukaemia (ALL)
QuestionChoice
Aplastic anaemia is characterised by pancytopenia and hypoplastic bone marrow. Although aplastic anaemia is a valid differential for the signs of anaemia (e.g. fatigue, palpitations), it would not explain the high white cell count in this case.
10001394
c
Aplastic anaemia
Concept
Chapter
2693
3922
haematological malignancies
Topic
157
Haematology
Acute myeloblastic leukaemia (AML)
12825
An 84-year-old male presents to his GP with a sore throat. He explains that he has felt fatigued over the past 4 months, and intermittently feels his heart beating hard and fast. He also mentions that he has lost a large amount of weight. On examination, he appears cachexic and has hepatomegaly.



Blood results show the following:


||||
|--------------|:-------:|---------------|
|Haemoglobin|68 g/L|(M) 130 - 170, (F) 115 - 155|
|Mean Cell Volume (MCV)|89 fL|80 - 96|
|White Cell Count|24x10<sup>9</sup>/L|3.0 - 10.0|
|Neutrophils|1.2x10<sup>9</sup>/L|2.0 - 7.5|
|Lymphocytes|2x10<sup>9</sup>/L|1.5 - 4.0|
|Monocytes|0.4x10<sup>9</sup>/L|0.2 - 1.0|
|Eosinophils|0.1x10<sup>9</sup>/L|0 - 0.4|
|Basophils|0.1x10<sup>9</sup>/L|0 - 0.1|
|Platelets|80x10<sup>9</sup>/L|150 - 400|
|Urea|6 mmol/L|2.5 - 7.8|
|Creatinine|110 µmol/L|60 - 120|
|Calcium|2.3 mmol/L|2.2 - 2.6|


A blood film shows Auer rods.



Based on the clinical history and the above findings, what is the most likely diagnosis?
a