QuestionSBA
QuestionChoice
Oncogenes code for oncoproteins, which act to promote cell division and tumour growth. One of the methods by which they do this is by binding to tumour suppressor genes, inactivating them.
10027166
a
The proteins they code for bind to and inactivate tumour suppressor genes, allowing rapid uncontrolled cell division
QuestionChoice
This is one of the actions of the p53 tumour suppressor gene, which has several mechanisms of action aiming to maintain genomic stability.
10027170
e
They initiate apoptosis if there becomes irreparable DNA damage in a cell
QuestionChoice
The elongation of telomeres is not well characterised. Shortening of the telomeres of chromosomes happens as cells divide as we age, and is associated with ageing and the development of disease (e.g. cancer). Oncogenes may have effects to increase telomere shortening.
10027168
c
They allow elongation of telomeres, protecting cancer cells from apoptosis
QuestionChoice
Pro-apoptotic proteins that interact with mitochondria to trigger apoptosis include BAX and BAK. These are regulated by a complex protein system, including pro-survival BCL2-like proteins. In tumour cells, oncogenes act to prevent apoptosis, so that cells can grow and divide in a rapid, uncontrolled way.
10027167
b
They both directly and indirectly interact with mitochondria to trigger apoptosis
QuestionChoice
Mutations or down regulation of tumour suppressor genes, not oncogenes, is a common mechanism tumour cells use to become resistant to cytotoxic drugs.
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d
Mutation or down regulation of oncogenes allows tumour cells to be highly resistant to cytotoxic drugs
Concept
Chapter
2693
4315
Molecular basis of cancer
Topic
182
Cancer Biology
17831
Which statement describes how oncogenes may affect tumour growth?
a