QuestionSBA
QuestionChoice
Although amlodipine is a Calcium-Channel Blocker that reduces peripheral vascular resistance by inhibiting vascular smooth muscle contraction and cardiac muscle contraction, it is not indicated in heart failure.
10002519
d
Amlodipine - lowers heart rate
QuestionChoice
Whilst propanolol causes lower arterial blood pressure, it is not due to vasodilation, it is instead due to less calcium influx through L-type calcium channels on cardiomyocytes, decreasing the heart rate. Propanolol is not used in patients with heart failure
10002518
c
Propanolol - causes vasodilation
QuestionChoice
Although Ivabradine reduces heart rate by acting on the sinoatrial node, it is second-line management in heart failure.
10002520
e
Ivabradine - reduces heart rate
QuestionChoice
Ramipril is an ACE inhibitor (ACEi) that inhibits the conversion of Angiotensin I into Angiotensin II. Amongst other funstions, angiotensin II causes vasoconstriction, so by inhibiting its production, the ACEi Ramipril is able to cause vasodilation, reducing strain on the heart. Angiotensin II has a number of other effects that lead to lowering of blood pressure, including: sympathetic activation, sodium reabsorption in the kidneys, aldosterone release and ADH release.
10002516
a
Ramipril - causes vasodilation
QuestionChoice
Whilst Furosemide inhibits Na-K-Cl cotransporters in the thick ascending loop of Henle, it is nor first line management in heart failure.
10002517
b
Furosemide - loop diuretic
Concept
Chapter
2693
3798
Heart Failure
Topic
134
Cardiology
13050
A 76-year-old female has been diagnosed with Left Ventricular Systolic dysfunction and Heart failure after being referred to a cardiologist by her GP following swollen ankles. The cardiologist prescribes some medication which she has to take once a day.

What is the name of this medication and what is the mechanism of action?
a