QuestionSBA
QuestionChoice
Anti-Ro (and Anti-La) antibodies are diagnostic of Sjogren’s syndrome. Patients with Sjogren’s syndrome are known for being DRY (i.e. dry mucous membranes, dry skin, dry eyes, etc), and a common test used in the diagnostic workup of the syndrome is the Schirmer’s test.
10003384
d
Anti-Ro
QuestionChoice
Anti-CCP antibodies are usually found in rheumatoid arthritis (RA). RA is unlikely to present with a facial rash. It typically presents with symmetrical polyarthritis affecting the MCPs and PIPs of the hand and sparing the DIPs, but it may also affect larger joints. Other features include extra-articular symptoms.
10003382
b
Anti-CCP
QuestionChoice
Anti-cardiolipin antibodies are characteristic findings in anti-phospholipid syndrome. These patients typically present with a pro-coagulative state that leads to high numbers of miscarriages, venous thromboembolism events and musculoskeletal diseases (e.g. inflammatory arthritis).
10003385
e
Anti-cardiolipin
QuestionChoice
Anti-histone antibodies are characteristic of drug-induced lupus which is the most likely diagnosis here. This patient is taking hydralazine and isoniazid which are drugs that commonly cause drug-induced Lupus.
10003381
a
Anti-histone
QuestionChoice
Anti-dsDNA antibodies are diagnostic of systemic lupus erythematosus (SLE). These patients have a variety of symptoms including joint pain, rash, serositis, and heart conduction abnormalities.
10003383
c
Anti-dsDNA
Concept
Chapter
2693
4154
Autoantibodies
Topic
146
Rheumatology
13223
A 29-year-old woman presents to her GP with an erythematous facial rash and joint pain. Her current medications include ramipril, isoniazid, hydralazine, paracetamol PRN and Microgynon 30.

What is the likely autoantibody found in her condition?
a