QuestionSBA
QuestionChoice
There is no requirement to check the function of the liver before taking ibuprofen.
50134
d
She must have liver function tests before starting taking ibuprofen
QuestionChoice
Gastrointestinal discomfort is a very common side effect of ibuprofen use, especially with long term use. Ibuprofen inhibits the cyclo-oxygenase enzyme. This in turn increases the production of prostanoids such as prostaglandins. These prostaglandins then reduce the efficacy of the mucosal barrier within the stomach, making stomach ulcers more likely.
50131
a
A long course of ibuprofen increases her risk of stomach ulcers
QuestionChoice
Ibuprofen can increase a patient's cardiovascular risk however this is often the case in those with pre-existing cardiovascular disease who are taking ibuprofen long term.
50132
b
A long course of ibuprofen will decrease her cardiovascular risk
QuestionChoice
A penicillin allergy has no cross-sensitivity with penicillin based medications, it does however have cross-sensitivity with other non steroidal anti-inflammatories and aspirin.
50133
c
She must not take ibuprofen if she has an allergy to amoxicillin
QuestionChoice
Whilst constipation is a side effect of ibuprofen it is a rare/very rare side effect and therefore is unlikely to occur.
50135
e
She is likely to experience constipation when taking ibuprofen
Concept
Chapter
Osteoporosis, otherwise known as thin bones, is a condition associated with high risk of low trauma fractures due to reduced bone mineral density. Osteoclast activity exceeds osteoblast activity, meaning that bone resorption is occurring at a greater rate than bone formation.

**Symptoms and Signs**

- Generally asymptomatic until a fragility fracture occurs
- Back pain
- Kyphosis (stooped posture)
- Fragility fractures

**Risk factors**

- Female sex
- Increasing age
- Smoking
- Corticosteroid use
- Low BMI (< 20-25kg/m<sup>2</sup>)
- Low body weight (<58kg)
- Vitamin D deficiency

**Protective factors**

- Higher BMI
- Exercise - mechanical loading stimulates bone formation

**Diagnosis**
Osteoporosis can be detected on dual-energy x-ray absorptiometry (DEXA) scan.
A T score of < -2.5 indicates osteoporosis

**Management**

- Fall prevention
- Vitamin D and calcium supplementation
- Hormone replacement therapy (postmenopausal women)
- Oral bisphosphonates
2657
3606
Ibuprofen increases the risk of gastric ulcer formation
Topic
92
General Practice
10074
Case presentation: A 54-year-old woman attends the GP with back pain. This back pain started after she bent over to pick up her phone off the floor yesterday. She has no neurological or sensory deficits. She is not incontinent.



**PH**
Depression

**DH**
Sertraline 50mg

One of the medications offered includes ibuprofen, which is offered to the patient to relieve their back pain.

Question: Select the most important information that should be provided for this patient.
a