QuestionSBA
QuestionChoice
A chondroma is a benign cartilaginous growth which commonly affects the small bones of the hands and feet, the femur and the humerus. Typically, a chondroma does not present with red flag symptoms.
10003368
c
Chondroma
QuestionChoice
Multiple myeloma is a malignant disease of bone marrow plasma cells characterised by >10% plasma cells in the bone marrow and CRAB (hyper**c**alcaemia, **r**enal failure, **a**naemia and lytic **b**one lesions) features. It is not a complication of Paget’s disease.
10003369
d
Multiple myeloma
QuestionChoice
Ewing sarcoma is a primary malignancy of bone commonly affecting people under 25 years old. It largely affects the diaphysis of long bones and is associated with a t(11;22) translocation. It is not a complication of Paget’s disease.
10003367
b
Ewing sarcoma
QuestionChoice
Acute lymphoblastic leukaemia is a common childhood blood cancer. It is most common in children with Down’s syndrome, a history of carcinogen exposure (e.g. benzene, arsenic), and positive family history of ALL. It is not a complication of Paget’s disease.
10003370
e
Acute lymphoblastic leukaemia (ALL)
QuestionChoice
This man has Paget’s disease. A complication of Paget’s disease is malignant transformation, typically to osteosarcoma, which presents with red flag symptoms such as weight loss, night sweats and fever.
10003366
a
Osteosarcoma
Concept
Chapter
2693
4151
Paget’s disease
Topic
145
Orthopaedics
13220
A 67-year-old man presents to the GP with pain in his right leg. He also has hearing loss. The doctor conducts some blood tests.


The results are shown below:

||||
|---------------------------|:-------:|--------------------|
|Alkaline Phosphatase (ALP)|300 IU/L|25 - 115|
|Calcium|2.3 mmol/L|2.2 - 2.6|
|Vitamin D|30 nmol/L|>50|

The GP prescribes him paracetamol and alendronic acid.


 8 years later, the same patient presents to his GP complaining of night sweats, fever and weight loss.


What is the most likely complication of his original condition that has occurred here?
a