QuestionSBA
QuestionChoice
Liver disease can impair the production of clotting factors, including those dependent on vitamin K. These factors are essential for both the intrinsic (APTT) and extrinsic (PT) coagulation pathways. Vitamin K is necessary for synthesising factors II, VII, IX and X. The impaired synthesis and decreased availability of vitamin K in liver disease can lead to prolonged PT and APTT.
10028086
a
Vitamin K deficiency
QuestionChoice
Thrombocytosis refers to an elevated platelet count and is not a common cause of prolonged PT and APTT.
10028090
e
Thrombocytosis
QuestionChoice
Factor IX deficiency is associated with haemophilia B and typically results in prolonged APTT; however, it does not significantly affect PT.
10028089
d
Factor IX deficiency
QuestionChoice
Factor VIII deficiency is associated with haemophilia A. It typically results in prolonged APTT but does not significantly affect PT.
10028088
c
Factor VIII deficiency
QuestionChoice
Platelet dysfunction is not typically associated with prolonged PT and APTT. It is more relevant to bleeding disorders related to platelet function, such as von Willebrand disease.
10028087
b
Platelet dysfunction
Concept
Chapter
2693
4340
Interpretation of blood results in bleeding disorders
Topic
157
Haematology
18015
A 59-year-old man presents with a 2-day history of abdominal pain and dark, tarry stools.

He has a history of liver disease.

**Blood results reveal the following:**

* Haemoglobin: 7.8 g/dL *(normal range: >12 g/dL)*
* Platelet count: 190,000/uL *(normal range: 150,000 - 45000/uL)*
* Prothrombin Time (PT): *26 seconds (normal range: 11 - 13.5 seconds)*
* Activated Partial Thromboplastin Time (APTT): 53 seconds *(normal range: 27 - 41 seconds)*

Which of the following factors is most likely contributing to the abnormal blood results in this patient?
a