QuestionSBA
QuestionChoice
Pernicious anaemia is primarily characterised by a deficiency of vitamin B12 (cobalamin) due to impaired absorption in the gastrointestinal tract. It is typically caused by the autoimmune destruction of parietal cells in the stomach, which results in a lack of intrinsic factor. Intrinsic factor is essential for the absorption of vitamin B12 in the ileum. The deficiency of vitamin B12 results in the characteristic features of pernicious anaemia: macrocytic megaloblastic anaemia, neurological symptoms, and other systemic manifestations.
10024115
a
Vitamin B12 (cobalamin)
QuestionChoice
Vitamin C deficiency leads to a condition called scurvy which is characterised by gum bleeding, skin changes, and muscle weakness. It is unrelated to the underlying mechanism of pernicious anaemia, which is specifically associated with vitamin B12 deficiency.
10024118
d
Vitamin C (ascorbic acid)
QuestionChoice
Vitamin D deficiency results in various manifestations, such as rickets in children and osteomalacia in adults. These conditions are associated with calcium and phosphate metabolism, bone health, and the musculoskeletal system. Vitamin D deficiency is not the primary cause of pernicious anaemia, which primarily involves a vitamin B12 deficiency.
10024119
e
Vitamin D (cholecalciferol)
QuestionChoice
Pernicious anaemia is not related to iron deficiency. Iron deficiency anaemia is a distinct condition caused by insufficient dietary iron intake or impaired iron absorption. In pernicious anaemia, the primary issue is the inability to absorb vitamin B12 due to a lack of intrinsic factor.
10024116
b
Iron
QuestionChoice
Whilst a deficiency of folate can also lead to a macrocytic megaloblastic anaemia, it is not the primary nutrient deficiency associated with pernicious anaemia. Pernicious anaemia specifically involves vitamin B12 deficiency due to impaired absorption.
10024117
c
Folate (vitamin B9)
Concept
Chapter
2693
5738
Pernicious Anaemia
Topic
294
Anaemia
17221
Pernicious anaemia is characterised by a deficiency of which essential nutrient due to impaired absorption?
a