QuestionSBA
QuestionChoice
This is incorrect. Sjogren's syndrome is associated with a positive anti-Ro and anti-La. Symptoms of fatigue, fever and myalgia, although non-specific are all congruent with a diagnosis of SLE. The positive antibodies confirm this diagnosis.
10027703
c
Sjogren's syndrome
QuestionChoice
This is correct. Symptoms of fatigue, fever and myalgia, although non-specific are all congruent with a diagnosis of SLE. The positive antibodies confirm this diagnosis.
10027701
a
Systemic lupus erythematous (SLE)
QuestionChoice
This is incorrect. Approximately 50-90% of patients with rheumatoid arthritis present with a positive rheumatoid factor and >95% present with a positive anti-CCP. Symptoms of fatigue, fever and myalgia, although non-specific are all congruent with a diagnosis of SLE. The positive antibodies confirm this diagnosis.
10027702
b
Rheumatoid arthritis
QuestionChoice
This is incorrect. Wegener's granulomatosis is associated with a positive cANCA. Symptoms of fatigue, fever and myalgia, although non-specific are all congruent with a diagnosis of SLE. The positive antibodies confirm this diagnosis.
10027704
d
Wegener's granulomatosis
QuestionChoice
This is incorrect. Diffuse cutaneous systemic sclerosis is associated with a positive Anti-Scl-70. Symptoms of fatigue, fever and myalgia, although non-specific are all congruent with a diagnosis of SLE. The positive antibodies confirm this diagnosis.
10027705
e
Diffuse cutaneous systemic sclerosis
Concept
Chapter
2693
5687
Antibodies in rheumatological disease
Topic
146
Rheumatology
17938
A 33 year old female attends their GP to discuss the results of a recent blood test. They have been feeling more tired than usual and complain of a low-grade fever affecting their ability to concentrate. They also report widespread muscle and joint aches despite minimal physical exertion.

Their blood results are as follows:

Anti-dsDNA: positive.
Anti-sm: positive.
ANA: positive.

All other auto-antibody tests were negative.

Which of the following is the most likely underlying diagnosis?
a