QuestionSBA
QuestionChoice
Osteocytes regulate local mineral deposition and chemistry of the bone matrix. Evidence shows that bisphosphonates may indirectly promote osteocyte activity and have direct anti-apoptotic effects on these cells.
10001615
d
Inhibit osteocyte activity
QuestionChoice
Osteoclasts are the cells that degrade bone to initiate normal bone remodelling and mediate bone loss in pathologic conditions such as osteoporosis by increasing their resorptive activity. Bisphosphonates work to inhibit osteoclast activity thus aiming to maintain bone structure and density.
10001612
a
Inhibit osteoclast activity
QuestionChoice
Osteoblasts are the bone cells that are primarily responsible for synthesizing bone matrix proteins and minerals. Evidence shows that bisphosphonates have anti-apoptotic effects on osteoblasts and thus are likely to promote rather than inhibit their activity.
10001613
b
Inhibit osteoblast activity
QuestionChoice
Osteoclasts are the cells that degrade bone to initiate normal bone remodelling and mediate bone loss in pathologic conditions such as osteoporosis by increasing their resorptive activity. Bisphosphonates work to inhibit osteoclast activity thus aiming to maintain bone structure and density.
10001614
c
Promote osteoclast activity
QuestionChoice
This is not a function of bisphosphonates.
10001616
e
Stimulates blood vessel formation
Concept
Chapter
2693
3949
Bone pathology
Topic
164
Physiology and pathology of bone
12869
A 76-year-old woman is commenced on bisphosphonates. The GP explains the mechanism of action of this drug.

Which of the following is correct?
a