QuestionSBA
QuestionChoice
Primary sclerosing cholangitis (PSC) is a chronic liver disease characterised by inflammation and scarring of the bile ducts. It can also lead to raised liver enzymes and cholestasis. PSC is often associated with inflammatory bowel disease and has a strong association with ulcerative colitis.
10027998
c
Primary sclerosing cholangitis
QuestionChoice
Autoimmune hepatitis is characterised by autoimmune-mediated inflammation of the liver. It can also present with raised ALP and bilirubin however, it is typically associated with anti-smooth muscle antibodies and not anti-mitochondrial antibodies.
10027997
b
Autoimmune hepatitis
QuestionChoice
Hepatocellular carcinoma is a malignancy of the liver and usually occurs in patients with underlying liver disease such as cirrhosis. It can cause raised liver enzymes, jaundice and dark urine.
10027999
d
Hepatocellular carcinoma
QuestionChoice
Non-alcoholic fatty liver disease (NAFLD) is characterised by the accumulation of fat in the liver and can progress to non-alcoholic steatohepatitis (NASH). Raised liver enzymes can also occur in NAFLD, but NAFLD does not cause the characteristic cholestasis as seen in PBC.
10028000
e
Non-alcoholic fatty liver disease
QuestionChoice
Primary biliary cholangitis (PBC) is a chronic autoimmune disease characterised by the progressive destruction of small bile ducts within the liver. The symptoms of itching, jaundice and dark urine with raised bilirubin are indicative of cholestasis resulting from impaired bile flow. Raised ALP is found due to damage to the bile ducts. Anti-mitochondrial antibodies are found in more than 90% of individuals with PBC.
10027996
a
Primary biliary cholangitis
Concept
Chapter
2693
6024
Primary biliary cholangitis
Topic
136
Gastroenterology
17997
A 45-year-old woman presents to the GP with a longstanding history of itching, jaundice and dark urine. Her blood results show raised alkaline phosphatase (ALP) and bilirubin levels and anti-mitochondrial antibodies.

What is the most likely diagnosis?
a