QuestionSBA
QuestionChoice
ADH acts upon the collecting duct, rather than the proximal convoluted tubule. Nephrogenic diabetes insipidus does not involve ADH resistance of the proximal convoluted tubule, making this answer incorrect.
10025779
e
The proximal convoluted tubule
QuestionChoice
ADH is synthesised, stored and released from the **posterior** pituitary gland not the anterior. Furthermore, this question describes a case of **nephrogenic** diabetes insipidus and thus the pituitary gland is unaffected.
10025776
b
Anterior pituitary gland
QuestionChoice
ADH acts upon the collecting duct, rather than the renal glomerulus. Nephrogenic diabetes insipidus does not involve ADH resistance of the glomerulus, making this answer incorrect.
10025778
d
The glomerulus of the nephron
QuestionChoice
The posterior pituitary gland is responsible for the synthesis, storage and release of ADH. In **cranial** diabetes insipidus, there is a lack of ADH secretion. However, this question features **nephrogenic** diabetes insipidus and therefore this answer is incorrect.
10025777
c
Posterior pituitary gland
QuestionChoice
Nephrogenic diabetes insipidus is a condition in which the kidney fails to respond to ADH. This can be caused by a multitude of factors, however, the likely cause in this vignette is lithium which is being used as a mood stabiliser for this patient's bipolar affective disorder. ADH acts on the distal convoluted tubule and collecting ducts of the nephron, which increases the presence of aquaporin-2 channels allowing for water reabsorption.
10025775
a
The collecting ducts of the nephron
Concept
Chapter
2693
4084
Antidiuretic hormone
Topic
168
Renal Physiology
17553
A 35 year old male attends an endocrinology clinic with one month of polyuria, nocturia and polydipsia. He has a diagnosis of bipolar affective disorder but has been stable for several years on lithium. A water deprivation test diagnoses nephrogenic diabetes insipidus.

Which of the following structures has developed resistance to anti-diuretic hormone (ADH)?
a