QuestionSBA
QuestionChoice
Cholera toxin is an exotoxin and leads to the activation of cAMP-mediated anion secretion and inhibition of NaCl absorption. This promotes massive chloride ion secretion and water loss into the gut causing secretory, "rice water" diarrhoea.
10026810
a
Cholera subunit B binds to enterocytes and facilitates the entry of cholera subunit A which promotes massive chloride ion secretion and water loss
QuestionChoice
Cholera toxin is an exotoxin**,** not an endotoxin. it does not react with lipopolysaccharide-sensitive cells
10026812
c
Cholera endotoxins react with lipopolysaccharide-sensitive cells resulting in the production of inflammatory mediators. This leads to the mass secretion of chloride ions and water loss
QuestionChoice
Cholera toxin is an exotoxin. Subunit B facilitates the entry of subunit A into enterocytes and promotes the mass secretion of chloride ions into the gut. Water follows the movement of chloride ions leading to secretory diarrhoea
10026813
d
Cholera subunit B binds to lipopolysaccharide-sensitive cells resulting in the production of inflammatory mediators leading to mass absorption of chloride ions and water loss
QuestionChoice
Secretory diarrhoea from cholera is due to the massive secretion of **chloride** ions, not sodium ions.
10026811
b
Cholera subunit B binds to enterocytes and facilitates the entry of cholera subunit A which promotes massive sodium ion secretion and water loss
QuestionChoice
Cholera toxin is an exotoxin and leads to the activation of cAMP-mediated anion secretion and inhibition of NaCl absorption. This promotes massive chloride ion secretion and leads to the movement of water into the gut lumen resulting in secretory, "rice water" diarrhoea
10026814
e
Cholera subunit B binds to enterocytes and facilitates the entry of cholera subunit A which promotes massive chloride ion absorption and water loss
Concept
Chapter
2693
5924
Exotoxins
Topic
148
Microbiology
17760
A 28-year-old male who has returned from travelling Africa presents to the emergency department with profuse painless diarrhoea, abdominal discomfort, borborygmi and vomiting in the absence of fever. The doctor suspects cholera.

Which of the following best describes the pathogenic mechanism of *Vibrio cholera*?
a