QuestionSBA
QuestionChoice
This is the 1st line treatment for opioid dependence, not an acute overdose as seen in this case. Taking methadone is known to reduce patients' withdrawal symptoms and cravings for opioids. However, the patient in this case demonstrates acute opioid toxicity, making naloxone the most appropriate management option.
10025616
b
Methadone
QuestionChoice
This is a very potent, short-acting opioid. However, the patient in this case demonstrates acute opioid toxicity, making naloxone the most appropriate management option. It would not be appropriate to administer further opioid medications.
10025619
e
Alfentanil
QuestionChoice
This is an opioid receptor agonist used in the treatment of diarrhoea. However, the patient in this case demonstrates acute opioid toxicity, making naloxone the most appropriate management option.
10025618
d
Loperamide
QuestionChoice
This is the 1st line treatment for individuals suffering from an acute benzodiazepine overdose. Key signs of a benzodiazepine overdose include ataxia and slurred speech. However, the patient in this case demonstrates acute opioid toxicity, making naloxone the most appropriate management option.
10025617
c
Flumazenil
QuestionChoice
The signs of respiratory depression, reduced consciousness and pinpoint pupils are strongly suggestive of an opioid overdose. Acute reversal is needed. Naloxone is the recommended reversal agent in opioid toxicity, acting as a full antagonist at opioid receptors.
10025615
a
Naloxone
Concept
Chapter
2693
4034
Opioid toxicity
Topic
161
Emergency Medicine
17521
A 22 year old woman is brought to the emergency department by ambulance after being found lying on the floor of her bedroom by her sister. Her sister notes she was holding an empty medication bottle when found, but is unsure what it contained.

On examination, the patient is finding it difficult to speak, muttering indistinct words and only opening her eyes to verbal commands. She is unable to pinch the fingers of one of the nurses when asked but is capable of localising to supraorbital pain. In addition, her pupils are bilaterally reduced in size. She has a respiratory rate of 8 breaths per minute, but all other observations are within the normal limits.

Which of the following is the most appropriate acute management option?
a