QuestionSBA
QuestionChoice
The raised ALP alongside low phosphate and low calcium is evidence of failed bone mineralisation; this is seen in osteomalacia, resulting in softer and more brittle bones,
10001326
a
Osteomalacia
QuestionChoice
The muscle weakness described in this patient is consistent with polymyositis, however, the calcium, phosphate and ALP levels would be normal in polymyositis. Creatine kinase would also be elevated.
10001329
d
Polymyositis
QuestionChoice
The muscle aches align with fibromyalgia as a differential diagnosis, however, the abnormal blood test results do not. The calcium, phosphate and ALP levels would be normal in fibromyalgia.
10001330
e
Fibromyalgia
QuestionChoice
In Paget’s disease, the ALP is very raised (more than in osteomalacia), but the calcium and phosphate are usually normal.
10001328
c
Paget’s disease
QuestionChoice
Osteopenia would present with normal bloods and reduced bone density.
10001327
b
Osteopenia
Concept
Chapter
2693
3910
osteomalacia
Topic
170
Clinical Chemistry
12812
A 40-year-old female presents to the GP following 6 months of muscle aches and fatigue. She has also experienced difficulty climbing up the stairs in her home.


Her blood test results are as follows:

||||
|---------------------------|:-------:|--------------------|
|Calcium|2.0 mmol/L|2.2 - 2.6|
|Phosphate|0.52 mmol/L|0.8 - 1.5|
|Alkaline Phosphatase (ALP)|240 IU/L|25 - 115|


What is the most likely diagnosis?
a