QuestionSBA
QuestionChoice
Montelukast is not a corticosteroid. This description fits drugs such as beclomethasone, which can be used in asthma management.
10002070
d
Montelukast is a corticosteroid that works to inhibit inflammatory cells and the release of inflammatory mediators
QuestionChoice
This is the mechanism of action for montelukast. It targets CysLT1 leukotriene receptors found on eosinophils, mast cells and airway smooth muscle cells.
10002067
a
Montelukast is a CysLT1 leukotriene receptor antagonist that decreases eosinophil migration, bronchoconstriction and inflammation-induced oedema
QuestionChoice
This is the mechanism of theophylline. Inhibition of phosphodiesterases leads to the reduced breakdown of cyclic AMP in smooth muscle cells. This is thought to result in bronchodilation and relaxed smooth muscle. Theophylline can be used to manage asthma and COPD.
10002071
e
Montelukast inhibits type III and IV phosphodiesterase, which leads to bronchodilation and relaxed smooth muscle in the bronchial airways
QuestionChoice
This is the mechanism of action for salbutamol, which is a different drug used in asthma treatment. It is more commonly used in asthma management than montelukast.
10002068
b
Montelukast is a B2-receptor agonist. Once these receptors are activated, Ca2+ entry is reduced which prevents smooth muscle contraction
QuestionChoice
This is the mechanism of action of fluticasone and mometasone. Alongside targeting eosinophils and monocytes, they also target mast cells, macrophages and dendritic cells.
10002069
c
Montelukast has multiple actions on different cell types - it directly decreases inflammatory cells like eosinophils and monocytes and also reduces the number of cytokines produced by these cells
Concept
Chapter
2693
3725
Asthma
Topic
132
Respiratory
12960
Montelukast can be used in the management of asthma.

What is the mechanism of action of montelukast?
a