QuestionSBA
QuestionChoice
GABA-alpha antagonists are used in benzodiazepine overdoses and have no neuropathic pain-relieving properties.
10023574
e
GABA-alpha antagonists
QuestionChoice
These drugs, such as baclofen, act on GABA-beta receptors to decrease spasticity in conditions such as cerebral palsy.
10023571
b
GABA-beta agonists
QuestionChoice
Selective serotonin reuptake inhibitors (SSRI) stop the reuptake of serotonin in the brain, resulting in increased concentrations of serotonin within synapses. SSRIs such as sertraline and fluoxetine are mainly used to treat depression and anxiety.
10023572
c
Selective serotonin reuptake inhibitor
QuestionChoice
Serotonin and noradrenaline reuptake inhibitors (SNRI) stop the reuptake of serotonin and noradrenaline, resulting in increased concentrations of these neurotransmitters within synapses. SNRIs such as duloxetine are used as second-line treatment for depression and anxiety, as well as for neuropathic pain.
10023573
d
Serotonin and noradrenaline reuptake inhibitor
QuestionChoice
Gabapentin acts to bind and inhibit pre-synaptic voltage-gated calcium channels, therefore reducing the density of these channels that are available for neurotransmission. This results in reduced excitatory neurotransmitter release which, in turn, reduces pain perception.
10023570
a
Binds to pre-synaptic voltage-gated calcium channels
Concept
Chapter
2693
3825
Pain sensation
Topic
152
Neuroscience
17112
A 58-year-old male with a background of previous disc herniation presents to the GP with sharp shooting pains going down his left arm. He says that the pain is constant and is stopping him from performing daily tasks. He also reports that sometimes his arm and hand go numb and tingly. He has tried paracetamol and amitriptyline which both have not helped the pain. The GP decides to prescribe him gabapentin.

What is the mechanism of action of this drug?
a