QuestionSBA
QuestionChoice
Correct. Omeprazole is a proton pump inhibitor (PPI) which works by irreversibly blocking the hydrogen-potassium ATPase (proton pump) in the gastric parietal cells, thus reducing the secretion of stomach acid.
10026070
a
Inhibition of gastric acid secretion by blocking the H+/K+ ATPase pump
QuestionChoice
Omeprazole is a proton pump inhibitor (PPI) which works by irreversibly blocking the hydrogen-potassium ATPase (proton pump) in the gastric parietal cells, thus reducing the secretion of stomach acid. Although this does indirectly protect the oesophageal lining by reducing its exposure to corrosive acid, it is not the best description of its mechanism of action.
10026072
c
Protection of the oesophageal lining
QuestionChoice
This is incorrect. Omeprazole is a proton pump inhibitor (PPI) which works by irreversibly blocking the hydrogen-potassium ATPase (proton pump) in the gastric parietal cells, thus reducing the secretion of stomach acid.
10026071
b
Enhancement of acid production in the stomach
QuestionChoice
This is incorrect. Omeprazole is a proton pump inhibitor (PPI) which works by irreversibly blocking the hydrogen-potassium ATPase (proton pump) in the gastric parietal cells, thus reducing the secretion of stomach acid. It does not directly inhibit histamine release but can indirectly reduce the effects of histamine by blocking the final step in acid production.
10026073
d
Inhibition of histamine release
QuestionChoice
This is incorrect. Omeprazole is a proton pump inhibitor (PPI) which works by irreversibly blocking the hydrogen-potassium ATPase (proton pump) in the gastric parietal cells, thus reducing the secretion of stomach acid. PPIs do not stimulate mucus production.
10026074
e
Stimulation of mucus production in the stomach
Concept
Chapter
2693
5874
Proton pump inhibitors
Topic
229
Pharmacology of the gastro-intestinal system
17612
A 32 year old male presents to his General Practitioner with symptoms of acid reflux. He reports drinking an average of 20 units of alcohol per week. The GP prescribes omeprazole to improve his acid reflux and refers him to the local drug and alcohol liaison service.

Which of the following best describes the mechanism of action of omeprazole?
a