QuestionSBA
QuestionChoice
Transforming growth factor β (TGF-β) receptors contain a serine-threonine receptor kinase. Binding causes dimerisation of the receptors, thus activating the receptor. This allows for the phosphorylation of the Smad protein. The complex then translocates to the nucleus where it regulates gene expression.
10024307
c
Transforming growth factor β (TGF-β)
QuestionChoice
Thyroid hormone binds to nuclear receptors, which are types of intracellular receptors. Thyroid hormone is bound to a binding globulin and transported through the plasma membrane. It then diffuses across the nucleus to bind to the thyroid hormone receptor (THR), causing gene transcription.
10024309
e
Thyroid hormone
QuestionChoice
Epidermal growth factor binds to tyrosine kinase receptors causing dimerisation and autophosphorylation. This activates other proteins in the signalling cascade.
10024305
a
Epidermal growth factor
QuestionChoice
Glucocorticoids bind to nuclear receptors, which are types of intracellular receptors. The glucocorticoid receptor (GR) is bound to a heat shock protein. Glucocorticoids cause dissociation of the heat shock protein and dimerisation of glucocorticoid receptors. This complex diffuses across the nuclear membrane to bind to the glucocorticoid response element which leads to gene transcription.
10024308
d
Glucocorticoids
QuestionChoice
Growth hormone acts on the JakSTAT signalling pathway. The binding of growth hormone causes the dimerisation of receptors containing Jak proteins. Jak proteins contain kinase activity and cause autophosphorylation and subsequent phosphorylation of the receptors. This dimer is able to dissociate and migrate to the nucleus where it regulates gene expression.
10024306
b
Growth hormone
Concept
Chapter
2693
4365
Types of cell signalling
Topic
166
General pharmacological concepts
17259
Cell signalling is important in metabolic regulation.

Which of the following substrates bind to tyrosine kinase receptors?
a