QuestionSBA
QuestionChoice
This is incorrect because it is actually characterised by abrupt changes in intracellular ion gradients not extracellular ion gradients
10009651
b
The cortical spreading depression is characterised by abrupt changes in extracellular ion gradients and sustained depolarisation of neurons
QuestionChoice
This is correct as the perceived answer is the enhanced trigeminovascular neuron activity, and the correct proposed theory is intracerebral vasoconstriction causing the aura and vasodilation causing the headache
10009654
e
Intracerebral vasoconstriction which causes headache and then vasodilation causing the aura
QuestionChoice
This is incorrect, in terms of genetics of the Migraine, 50% of cases are caused by point mutations in the CACNA1A gene that encodes the pore-forming a1a subunit of the P/Q Voltage-Gated Calcium Channel
10009653
d
Point mutations in the AHCNA1A gene
QuestionChoice
This is the incorrect answer, because the cortical spreading depression theory, states that higher extracellular K+ ion concentrations lead to inhibition of neural activity in the cortex
10009652
c
Within Cortical spreading depression, a lower extracellular K+ ion concentration leads to inhibition of neural activity in the cortex
QuestionChoice
This is the correct answer
10009650
a
Enhanced trigeminovasular neuron activity
Concept
Chapter
2693
4491
Migraine
Topic
141
Neurology
14478
There are several proposed aetiological concepts of the development of a migraine, which of the following is correct?
a