QuestionSBA
QuestionChoice
This is incorrect. Furosemide is a loop diuretic and so blocks the Na-K-Cl cotransporter (NKCC2) in the loop of Henle. This can lead to excess K+ loss in the urine, causing hypokalaemia. Hypokalaemia can disrupt the cardiac membrane potential resulting in arrhythmias.
10026398
d
Blocks Na+/Cl- cotransporter leading to hypernatraemia
QuestionChoice
This is incorrect. Furosemide is a loop diuretic and so blocks the Na-K-Cl cotransporter (NKCC2) in the loop of Henle. This can lead to excess K+ loss in the urine, causing hypokalaemia. Hypokalaemia can disrupt the cardiac membrane potential resulting in arrhythmias.
10026397
c
Blocks Na+/Cl- cotransporter leading to hyponatraemia
QuestionChoice
This is correct. Furosemide is a loop diuretic and so blocks the Na-K-Cl cotransporter (NKCC2) in the loop of Henle. This can lead to excess K+ loss in the urine, causing hypokalaemia. Hypokalaemia can disrupt the cardiac membrane potential resulting in arrhythmias.
10026395
a
Blocks NKCC2 leading to hypokalaemia
QuestionChoice
This is incorrect. Whilst furosemide does block NKCC2, this causes hypokalaemia, not hyperkalaemia. Blocking NKCC2 means less K+ is reabsorbed so more is lost in the urine, reducing serum K+ levels.
10026396
b
Blocks NKCC2 leading to hyperkalaemia
QuestionChoice
This is incorrect. This describes the mechanism of action of spironolactone. Furosemide is a loop diuretic and so blocks the Na-K-Cl cotransporter (NKCC2) in the loop of Henle. This can lead to excess K+ loss in the urine, causing hypokalaemia. Hypokalaemia can disrupt the cardiac membrane potential resulting in arrhythmias.
10026399
e
Inhibits aldosterone leading to hyperkalaemia
Concept
Chapter
2693
4018
Furosemide
Topic
188
Renal Pharmacology
17677
What is the mechanism through which furosemide can cause cardiac arrhythmias?
a