QuestionSBA
QuestionChoice
This presentation of an indolent, incidentally-diagnosed haematological malignancy presenting with an acute illness is characteristic of Richter's transformation of CLL to non-Hodgkin lymphoma (typically diffuse large B cell lymphoma). The history of being diagnosed with a haematological malignancy incidentally that was not actively treated is not typical of an initial diagnosis of acute leukaemia.
10035969
c
Acute Lymphocytic Leukaemia (ALL)
QuestionChoice
While hairy cell leukaemia is indolent and is usually not actively treated, it rarely transforms into an acute lymphoma/leukaemia. This presentation of an indolent, incidentally-diagnosed haematological malignancy presenting with an acute illness is characteristic of Richter's transformation of CLL to a non-Hodgkin lymphoma (typically diffuse large B cell lymphoma).
10035971
e
Hairy cell leukaemia
QuestionChoice
This presentation of an indolent, incidentally-diagnosed haematological malignancy presenting with an acute illness is characteristic of Richter's transformation of CLL to a non-Hodgkin lymphoma (typically diffuse large B cell lymphoma). The history of being diagnosed with a haematological malignancy incidentally that was not actively treated is not typical of an initial diagnosis of acute leukaemia.
10035970
d
Acute Myeloid Leukaemia (AML)
QuestionChoice
This presentation of an indolent, incidentally-diagnosed haematological malignancy presenting with an acute illness is characteristic of Richter's transformation of CLL to a non-Hodgkin lymphoma (typically diffuse large B cell lymphoma). This patient requires hospital admission and treatment with chemotherapy.
10035967
a
Chronic Lymphocytic Leukaemia (CLL)
QuestionChoice
While CML can enter the blast phase and transform into acute myeloid leukaemia, it would not be typical for a patient with CML to receive no treatment; a JAK inhibitor such as imatinib would usually be prescribed. This presentation of an indolent, incidentally-diagnosed haematological malignancy presenting with an acute illness is characteristic of Richter's transformation of CLL to a non-Hodgkin lymphoma (typically diffuse large B cell lymphoma). This patient requires hospital admission and treatment with chemotherapy.
10035968
b
Chronic Myeloid Leukaemia (CML)
QuestionComment
anyone have any mnemonics to remember all cml etc


54077
QuestionComment
This may sound stupid but: ALL is ALL kids (the most common in childhood), AML= acute in nature, and if you inverse the M it looks like a W so AW (AWr rods or Auer rods), CLL contains Smudge cells (if your write cll in lower case it can look non-descript/smudged) and you want to put the RICH(ters) in a CeLL (richters transformation). 
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j.g.73
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Medtsudent
Concept
Chapter
2693
6173
Chronic Lymphocytic Leukaemia (CLL)
Topic
157
Haematology
19597
Chronic Lymphocytic Leukaemia can transform into aggressive non-Hodgkin lymphoma, presenting with acute symptoms like fever and weight loss.
A 79-year-old man visits his general practitioner with fevers and significant weight loss after returning from a prolonged stay in Asia. He reports that he was diagnosed with a type of 'blood cancer' three years ago after a routine blood test, but has been very well and has not received any treatment for his condition.

On examination, he looks unwell and is cachectic. Firm, rubbery lymph nodes are palpated in the mandible and his spleen is enlarged.

Which haematological malignancy is he most likely to have been initially diagnosed with?
a