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Mentioning that the infusion is done twice a day leads to much confusion. The question is not worded properly.
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That's sometimes the point with these questions. They give you unnecessary information / distractors in the real PSA too.
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Misuuu
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Neoplasia Complement
Concept
Chapter
#### Monitoring

The BNF advises to monitor lung function (in patients with a history of obstructive airway disease).

#### Overdoses

Overdosages with beta-blockers may cause cardiac effects such as bradycardia, hypotension, syncope, conduction abnormalities, and heart failure. Bradycardia is the most common arrhythmia, but some beta-blockers may induce ventricular tachyarrhythmias secondary to prolongation of QT interval (e.g. sotalol) or QRS duration (e.g. propranolol).
Non-cardiovascular effects include central nervous system effects (including drowsiness, confusion, convulsions, hallucinations, and in severe cases coma), respiratory depression, and bronchospasm.

Management
 - Airway protection 
 - Activated charcoal within 1 hour
 - IV Fluids
 
IV glucagon is the first-line management.
 
For symptomatic bradycardia, IV atropine may be used.

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Calculation of infusion rate
Topic
9
Internal Medicine
The total dose to be given is: 20mg/kg x 75kg = 1500mg. We are not constrained by the maximum dose that can be given (2g) as 1500mg i.e. 1.5g is less than this limit. The shortest time period that vancomycin can be safely infused assumes it is run at at the maximum rate given. Hence, the time period is: 1500mg ÷ 10mg/min = 150 minutes. Given that there are 60 minutes in an hour, this is equivalent to 2 hours and 30 minutes.
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2.5
hours
A 58-year-old patient suffers from bacteraemia and MRSA was isolated from blood cultures. He is prescribed a vancomycin infusion of 20mg/kg twice a day. The maximum that can given per dose is 2g. The infusion runs at a maximum rate of 10mg/min. His weight is known to be 75kg.


What is the shortest time period (in hours) over which vancomycin can be safely infused?