QuestionSBA
QuestionChoice
Actinic keratosis is a pre-malignant skin condition that can lead to squamous cell carcinoma (SCC). The lesions normally appear as thickened papules or plaques with the skin texture appearing erythematous and keratotic. The incidence rate is higher in populations with fairer complexions and increased sun exposure. The keratinised nature and ulcerated edge of the lesion in this case makes an SCC more likely than actinic keratosis.
10027488
c
Actinic Keratosis
QuestionChoice
This answer is incorrect. Although dermatofibromas can sometimes present with mild tenderness on palpation, they tend to be asymptomatic and do not share the same characteristics of squamous cell carcinomas such as ulceration and bleeding.
10027489
d
Dermatofibroma
QuestionChoice
This is incorrect. Keratoacanthomas typically grow rapidly and develop from hair follicles in sun-exposed skin. They tend to appear as a dome-shaped nodule with a central keratin-filled hole. They can appear similar to a squamous cell carcinoma and therefore excision is usually recommended.
10027490
e
Keratoacanthoma
QuestionChoice
Squamous Cell Carcinomas (SSCs) tend to form on skin that is frequently exposed to the sun. They are a keratinocyte cancer, or non-melanoma, derived from cells within the epidermis that make keratin. They are invasive and can metastasise. SCCs can grow over weeks to months, may ulcerate and bleed, and are often painful.
10027486
a
Squamous Cell Carcinoma
QuestionChoice
This is incorrect. This type of skin cancer is also a non-melanoma which develops in the basal cells. These cells produce new types of skin cells when the older cells die off. Although basal cell carcinomas (BCC) also develop on sun exposed skin, these nodules tend to be asymptomatic (i.e. no pain or bleeding) and can have a pearly surface with a rolled edge.
10027487
b
Basal Cell Carcinoma
Concept
Chapter
2693
5787
Benign and malignant tumours
Topic
182
Cancer Biology
17895
A 60 year old caucasian female attends the dermatology clinic as they are concerned about a raised nodule on their ear. She states the growth has been slow but that the lesion has recently started bleeding. She is otherwise fit and well, with no regular medications. Although she is now retired, she used to work as a gardener.

On examination, the lesion appears keratinised with scale and an ulcerated edge. It is tender on palpation.

Which of the following is the most likely diagnosis?
a