QuestionSBA
QuestionChoice
KRAS mutations are more commonly associated with colorectal cancer and certain other cancers. They are not a primary genetic factor in hereditary breast cancer.
10024144
e
KRAS
QuestionChoice
Mutations in the BRCA1 gene are strongly associated with an increased risk of hereditary breast cancer. Individuals with BRCA1 mutations have a significantly higher lifetime risk of developing breast cancer, as well as ovarian cancer.
10024140
a
BRCA1
QuestionChoice
BCR-ABL gene fusions are characteristic of chronic myeloid leukaemia (CML) and are not directly related to breast cancer.
10024143
d
BCR-ABL
QuestionChoice
The EGFR (Epidermal Growth Factor Receptor) gene is not typically associated with hereditary breast cancer. EGFR mutations are more commonly linked to certain types of lung cancer and other malignancies.
10024142
c
EGFR
QuestionChoice
Mutations in the TP53 gene are associated with Li-Fraumeni syndrome, which increases the risk of various cancers, including breast cancer. However, BRCA1/BRCA2 mutations are more strongly associated with hereditary breast cancer.
10024141
b
TP53
Concept
Chapter
2693
5743
Genetics
Topic
298
Breast Cancer
17226
Which of the following genetic mutations is most strongly associated with an increased risk of hereditary breast cancer?
a