QuestionSBA
QuestionChoice
3rd generation cephalosporins such as ceftriaxone are useful against TEM-1 bacteria, however, are ineffective against ESBL A&B-producing bacteria. This means that these drugs will not be effective at treating mecA plasmid bacteria.
10023641
b
Ceftriaxone
QuestionChoice
Macrolides such as doxycycline are ineffective as the mecA plasmid usually has genes that encode proteins that make all macrolides ineffective. This means that doxycycline is not the correct antibiotic of choice for this patient.
10023643
d
Doxycycline
QuestionChoice
Aminoglycosides such as gentamicin are ineffective as the mecA plasmid usually has genes that encode proteins that make all aminoglycosides ineffective.
10023644
e
Gentamicin
QuestionChoice
The only class of drugs that counter mecA plasmid bacteria are glycopeptides. Vancomycin is a glycopeptide so can be used in this patient to help treat her infection.
10023640
a
Vancomycin
QuestionChoice
Aminopenicillins such as amoxicillin are ineffective as the mecA plasmid bacteria produce PBP2a (which the mecA plasmid gene encodes), which cannot be effectively inhibited by any beta-lactam. Therefore, this class of antibiotics are ineffective at treating mecA plasmid bacteria.
10023642
c
Amoxicillin
Concept
Chapter
2693
5691
Mechanisms of anti-microbial resistance
Topic
148
Microbiology
17126
A 93-year-old female is being treated for a UTI with broad-spectrum antibiotics. She is not feeling any better so urine cultures are sent to microbiology, who call back saying that there are bacteria present that have a mecA plasmid resistance.

What antibiotic would be best to treat this kind of bacteria?
a