QuestionSBA
QuestionChoice
This describes the mechanism of action of anti-viral drugs such as oseltamivir (Tamiflu). Sofosbuvir is a nucleotide analogue that inhibits viral ribonucleic acid (RNA) polymerase and as a result, leads to defunctive RNA replication and premature death of the virus.
10025563
d
Inhibits viral release from host cell
QuestionChoice
This describes the mechanism of drugs such as enfuvirtide, which is used to treat human immunodeficiency virus (HIV). Sofosbuvir is a nucleotide analogue that inhibits viral ribonucleic acid (RNA) polymerase and as a result, leads to defunctive RNA replication and premature death of the virus.
10025561
b
Inhibits viral to host cell fusion
QuestionChoice
Sofosbuvir is a nucleotide analogue that inhibits viral ribonucleic acid (RNA) polymerase and as a result, leads to defunctive RNA replication and premature death of the virus.
10025560
a
Inhibits viral nucleic acid replication
QuestionChoice
This describes the mechanism of antiviral drugs such as amantadine, which treats certain influenza infections. It works by stopping the virus from releasing its genetic material once inside the host cell. Sofosbuvir is a nucleotide analogue that inhibits viral ribonucleic acid (RNA) polymerase and as a result, leads to defunctive RNA replication and premature death of the virus.
10025562
c
Inhibits viral uncoating
QuestionChoice
This describes the mechanism of action of ledipasvir, which is also used in hepatitis C  treatment. It inhibits a protein that is required for viral replication. Sofosbuvir is a nucleotide analogue that inhibits viral ribose nucleic acid (RNA) polymerase and as a result, leads to defunctive RNA replication and premature death of the virus.
10025564
e
Inhibits viral protein synthesis
Concept
Chapter
2693
4039
Hepatitis viruses
Topic
136
Gastroenterology
17510
A 62 year old male with deranged liver function tests is diagnosed with a chronic hepatitis C infection. His gastroenterologist recommends starting a new anti-viral medication, sofosbuvir.

Which of the following best describes the mechanism of action of sofosbuvir?
a