QuestionSBA
QuestionChoice
No, this is not the correct answer. The patient demonstrates symptoms of a cholinergic crisis, caused by acetylcholine excess at the neuromuscular junction.
10007964
e
Dopamine deficiency
QuestionChoice
No, this is not the correct answer. The patient demonstrates symptoms of a cholinergic crisis, caused by acetylcholine excess at the neuromuscular junction.
10007961
b
Acetylcholine deficiency
QuestionChoice
No, this is not the correct answer. The patient demonstrates symptoms of a cholinergic crisis, caused by acetylcholine excess at the neuromuscular junction. Nicotinic acetylcholine receptor autoantibody formation describes the underlying pathophysiology of myasthenia gravis.
10007962
c
Nicotinic acetylcholine receptor autoantibody formation
QuestionChoice
No, this is not the correct answer. The patient demonstrates symptoms of a cholinergic crisis, caused by acetylcholine excess at the neuromuscular junction.
10007963
d
Dopamine excess
QuestionChoice
Yes, this is the correct answer. The patient demonstrates symptoms of a cholinergic crisis, also known as SLUDGE syndrome. This can be remembered by the mnemonic SLUDGE: **S**alivation, **L**acrimation, **U**rination, **D**efecation, **G**astrointestinal distress, and **E**mesis. Organophosphate poisoning is a relatively common cause of this. Acetylcholine excess causes overstimulation at the neuromuscular junction, resulting in the signs and symptoms demonstrated by this patient.
10007960
a
Acetylcholine excess
Concept
Chapter
2693
4634
Organophosphate Poisoning
Topic
166
General pharmacological concepts
14139
A 43-year-old man presents to A&E with severe vomiting, diarrhoea, and increased salivation from his oral cavity. These symptoms started around a week ago, and have been gradually worsening.

The patient is a farmer by occupation. He reports recently using a very old batch of insecticide on his crops.
It is eventually discovered that this contained the organophosphate known as parathion.

Which of the following describes the underlying pathophysiology of the patient's symptoms?
a