QuestionSBA
QuestionChoice
Levothyroxine is not associated with kidney injury. Levothyroxine has been shown to have some protective effects on the kidneys in certain patients with hypothyroidism.
10006885
e
Levothyroxine
QuestionChoice
Atorvastatin is not associated with kidney injury. However, it is recommended that the dose be reduced in cases of severe AKI.
10006884
d
Atorvastatin
QuestionChoice
This patient may be taking amolidipine for her hypertension, but it is not known to be nephrotoxic. It is an antihypertensive agent typically used as first-line treatment in patients of Afro-Carribean descent or those above the age of 55. ACE-inhibitors however, another common antihypertensive, are nephrotoxic and should be avoided in AKI.
10006883
c
Amlodipine
QuestionChoice
This patient's AKI is likely secondary to dehydration and subsequent hypovolaemia caused by her vomiting and diarrhoea. This results in a lack of blood flow to the kidneys. Ibuprofen is an NSAID, which is nephrotoxic, and may worsen this patient's acute kidney injury. Swapping to an alternative pain relief medication for her osteoarthritis would be appropriate whilst she is in AKI.
10006881
a
Ibuprofen
QuestionChoice
Lansoprazole is not known to be nephrotoxic. The patient is likely taking this for the prevention of NSAID-related gastric ulcer formation.
10006882
b
Lansoprazole
Concept
Chapter
2693
3752
Acute Kidney Injury
Topic
142
Nephrology
13923
A 74-year-old female has been suffering from vomiting and diarrhoea for the past four days on an inpatient ward. On examination, she appears dehydrated. Her renal function tests show a creatinine of 110 µmol/L (normal range 60-120µmol/L), and a urea of 16 mmol/L (normal range 2.5-7.8 mmol/L). She has a past medical history of hypertension, hypercholesterolaemia, hypothyroidism and osteoarthritis.

Which of the following medications is most likely to worsen this patient's acute kidney injury?
a