QuestionSBA
QuestionChoice
p53 is a tumour-suppressor gene. It has several mechanisms of action that aim to maintain genomic stability- one of which is initiating apoptosis if DNA damage is irreparable.
10004666
a
Initiates apoptosis if there is irreparable DNA damage
QuestionChoice
Shortening of the telomeres of chromosomes happens as cells divide as we age, and is associated with ageing and the development of disease (e.g. cancer). One of p53’s mechanisms to maintain genomic stability is by initiating a senescence response to shortened telomeres.
10004669
d
p53 causes the shortening of telomeres, protecting cancer cells from apoptosis
QuestionChoice
This is the mode of action of many oncoproteins, which act to promote cell division and tumour growth. p53 is a tumour suppressor gene, which has several mechanisms of action that aim to maintain genomic stability, preventing rapid uncontrollable cell growth.
10004668
c
It inactivates tumour suppressor genes by binding to them, allowing rapid uncontrolled cell division
QuestionChoice
p53 is a tumour-suppressor gene which acts by several mechanisms to maintain genomic stability. p53 is often mutated or downregulated in tumour cells, which allows them to be highly resistant to cytotoxic drugs.
10004670
e
High expression of p53 allows tumours to be highly resistant to cytotoxic drugs
QuestionChoice
Pro-apoptotic proteins that interact with mitochondria to trigger apoptosis include BAX and BAK. These are regulated by a complex protein system, including pro-survival BCL2-like proteins.
10004667
b
p53 is a pro-apoptotic protein that interacts directly with the mitochondria to trigger apoptosis
Concept
Chapter
2693
4315
Molecular basis of cancer
Topic
182
Cancer Biology
13480
Which statement best describes how p53 affects tumour growth?
a