QuestionSBA
QuestionChoice
The liver’s role in the renin-angiotensin-aldosterone system is to release angiotensinogen, which is then converted to angiotensin I by renin. The next step in the system is catalysed by ACE, an enzyme found on the surface of vascular endothelial cells predominantly in the lung.
10004735
e
They prevent the conversion of angiotensin I to angiotensin II in the liver
QuestionChoice
Angiotensinogen is converted to angiotensin I by plasma renin released by the kidney. Angiotensin I is then converted to angiotensin II by ACE, which is inhibited by ACE inhibitors.
10004732
b
They prevent the conversion of angiotensinogen to angiotensin I in the lung
QuestionChoice
Although they may somewhat indirectly affect renin release from the kidney, due to the negative feedback control of the renin-angiotensin-aldosterone system, this is not the primary mode of action of ACE inhibitors.
10004734
d
They directly inhibit the release of renin from the kidney
QuestionChoice
Angiotensin II acts to increase blood pressure by multiple methods, acting as an endocrine, autocrine and intracrine hormone. ACE inhibitors do not have any major effect on the direct actions of angiotensin II on blood vessels.
10004733
c
They prevent the direct action of angiotensin II on blood vessels, therefore limiting vasoconstriction
QuestionChoice
ACE inhibitors work by inhibiting ACE (angiotensin-converting enzyme). This is an enzyme which converts angiotensin I to angiotensin II and is found on the surface of vascular endothelial cells, predominantly in the lung.
10004731
a
They prevent the conversion of angiotensin I to angiotensin II in the lung
Concept
Chapter
2693
4215
ACE inhibitors
Topic
169
Cardiovascular pharmacology
13493
ACE (Angiotensin-Converting Enzyme) inhibitors are medications widely used in the treatment of hypertension and chronic kidney disease.

Which statement best describes the mode of action of ACE inhibitors?
a