QuestionSBA
QuestionChoice
This antibody is present in coeliac disease. This is tested for along with IgA antibodies to see the proportionate rise of anti-TTG.
10005945
e
Anti- tissue transglutaminase (Anti- TTG)
QuestionChoice
These are autoantibodies to the TSH receptor on the thyroid gland.

This can lead to Hashimoto's thyroiditis (hypothyroid) and Graves' disease (hyperthyroid).
10005942
b
Antithyroid peroxidase (anti-TPO)
QuestionChoice
This antibody helps to discover whether someone has either type 1 diabetes mellitus or latent autoimmune diabetes of the adulthood (LADA).

GAD is present in the beta cells of the pancreas and therefore show that these are damaged in this autoimmune condition leading to little to no insulin production.

This test has a high positive predictive value.
10005941
a
Anti- glutamic acid decarboxylase (anti-GAD)
QuestionChoice
This measures how much insulin is made in the body. It is not an antibody but a protein made when insulin is synthesised in the beta cells of the pancreas.

If no C-peptide is present, this suggests that the pancreas is producing little to no insulin.
10005943
c
C-peptide
QuestionChoice
This is positive in myasthenia gravis disease which causes muscle weakness which progressively becomes worse throughout the day.
10005944
d
Acetylcholine receptor antibody
Concept
Chapter
2693
4058
Diabetes Mellitus
Topic
167
Endocrine physiology
13735
12 year old boy presents to accident and emergency with polydipsia and polyuria. Preceding this he had 3 episodes of vomiting with abdominal pain.

He is diagnosed with diabetic ketoacidosis (DKA) and started on treatment including fluids and insulin infusion.

Which antibody is associated with Type 1 diabetes mellitus?
a