QuestionSBA
QuestionChoice
Ramipril is an angiotensin-converting enzyme (ACE) inhibitor. These drugs inhibit ACE, which mediates the conversion of angiotensin I to angiotensin II. Angiotensin II causes vasoconstriction, meaning that inhibition of this system via ACE inhibitors brings about vasodilation, thus lowering blood pressure. This answer is therefore correct.
10025760
a
The conversion of angiotensin I to angiotensin II in the lungs
QuestionChoice
Ramipril is an angiotensin-converting enzyme (ACE) inhibitor. By contrast, angiotensin II stimulates aldosterone release from the zona glomerulosa of the adrenal cortex. Ramipril does not directly inhibit this process.
10025763
d
The release of aldosterone
QuestionChoice
Ramipril is an angiotensin-converting enzyme (ACE) inhibitor. Angiotensinogen is cleaved by renin to form angiotensin I. This conversion happens independently of the action of ACE, making this option incorrect.
10025762
c
The conversion of angiotensinogen to angiotensin I
QuestionChoice
Ramipril is an angiotensin-converting enzyme (ACE) inhibitor. Whilst ACE is responsible for the conversion of angiotensin I to angiotensin II, this occurs mainly in the lungs rather than in the kidney. Therefore this is not the single best answer.
10025764
e
The conversion of angiotensin I to angiotensin II in the kidney
QuestionChoice
Ramipril is an angiotensin-converting enzyme (ACE) inhibitor. By contrast, renin is released from the juxtaglomerular apparatus in response to the action of macula densa cells, baroreceptors or beta-1 adrenoreceptors. This option is therefore incorrect.
10025761
b
The release of renin
Concept
Chapter
2693
4215
ACE inhibitors
Topic
169
Cardiovascular pharmacology
17550
A 48 year old caucasian male patient presents to his GP to review the results of his daily home blood pressure readings. He is subsequently diagnosed with hypertension and is prescribed ramipril as first-line therapy.

Which of the following components of the Renin-Angiotensin-Aldosterone system (RAAS) is inhibited by this drug?
a