QuestionSBA
QuestionChoice
Familial adenomatous polyposis is an autosomal dominant condition. This means that an individual needs to inherit just one copy of the defective allele for it to be reflected in the person's phenotype. It is encoded by alleles on the numbered non-sex chromosomes rather than through mitochondrial DNA, making this answer incorrect.
10025714
e
Mitochondrial
QuestionChoice
Familial adenomatous polyposis is an autosomal dominant condition. This means that an individual needs to inherit just one copy of the defective allele for it to be reflected in the person's phenotype. It is encoded by alleles on the numbered non-sex chromosomes, making this answer incorrect.
10025712
c
X-linked recessive
QuestionChoice
Familial adenomatous polyposis is an autosomal dominant condition. This means that an individual needs to inherit just one copy of the defective allele for it to be reflected in the person's phenotype.
10025711
b
Autosomal recessive
QuestionChoice
Familial adenomatous polyposis is an inherited disorder characterised by the growth of multiple colorectal polyps. This carries a high risk of malignant transformation and thus colorectal cancer development.

It is an autosomal dominant condition. This means that an individual needs to inherit just one copy of the defective allele for it to be reflected in the person's phenotype, meaning they have the disease. It also means that roughly 50% of children of an affected parent will inherit the condition. Individuals with familial adenomatous polyposis often first find out when they are genetically tested following the colorectal cancer diagnosis of a close relative.
10025710
a
Autosomal dominant
QuestionChoice
Familial adenomatous polyposis is an autosomal dominant condition. This means that an individual needs to inherit just one copy of the defective allele for it to be reflected in the person's phenotype. It is encoded by alleles on the numbered non-sex chromosomes, making this answer incorrect.
10025713
d
X-linked dominant
Concept
Chapter
2693
3731
Colorectal Cancer
Topic
136
Gastroenterology
17540
A 36 year old man attends a colorectal clinic to discuss a recent diagnosis of colorectal cancer. When asked about his family history, he reports having both an uncle and a brother who were similarly diagnosed with colorectal cancer at a young age. The clinician suspects a genetic cancer syndrome.

Which of the following best describes the genetic inheritance pattern of familial adenomatous polyposis?
a