QuestionSBA
QuestionChoice
No, this is not the correct answer. This patient has had no history of previous trauma or surgeries. This patient's drug history and presentation make a diagnosis of sickle cell disease the most likely.
10007861
b
Splenectomy
QuestionChoice
No this is not the correct answer. This patient's drug history and presentation make a diagnosis of sickle cell disease the most likely. By contrast, a patient with Hashimoto's disease would be prescribed an anti-thyroid medication such as levothyroxine.
10007864
e
Hashimoto's disease
QuestionChoice
No, this is not the correct answer. This patient's drug history and presentation make a diagnosis of sickle cell disease the most likely.
10007863
d
Systemic lupus erythematosus
QuestionChoice
This presence of DNA remnants in erythrocytes in the blood film are called Howell-Jolly Bodies. This finding suggests hyposplenism. There are many causes of hyposplenism and as this patient is prescribed hydroxycarbamide and penicillin (both of which are treatments for sickle cell disease) the patient is most likely to have sickle disease.

The presence of sickle cells in the bloodstream can result in infarcts and fibrosis of the spleen resulting in a lack of functioning splenic tissue. This impairs the ability of the spleen to sequestrate defective red blood cells, with DNA remnants resulting in Howell-Jolly bodies.
10007860
a
Sickle Cell Disease
QuestionChoice
No, this is not the correct answer. This patient's drug history and presentation make a diagnosis of sickle cell disease the most likely.
10007862
c
Coeliac disease
Concept
Chapter
2693
3921
sickle cell disease
Topic
157
Haematology
14119
A 17-year-old boy is admitted to the haematology ward following an acute episode of pain in his abdomen. He has no other history of trauma or previous surgeries. However, he is known to have a chronic medical condition, for which he is prescribed hydroxycarbamide and penicillin.

A blood film shows the presence of erythrocytes with small DNA remnants.

Which of the following is the most likely cause of his blood film appearance?
a