QuestionSBA
QuestionChoice
Growth factors, such as transforming growth factor-beta (TGF-beta) and platelet-derived growth factor (PDGF), play a role in tissue repair and regeneration, rather than tissue degradation. They stimulate cell proliferation and extracellular matrix production.
10024056
b
Growth factors
QuestionChoice
Antioxidants, such as vitamins C and E, help protect cells from oxidative damage and support tissue healing but are not directly responsible for tissue degradation.
10024057
c
Antioxidants
QuestionChoice
Whilst metalloproteinases, such as matrix metalloproteinases (MMPs), are involved in tissue remodelling and the degradation of damaged tissue, they are not produced by leukocytes and macrophages but by various cell types, including fibroblasts and endothelial cells. Leukocytes and macrophages release cytokines, such as IL-1, which can stimulate the production of metalloproteinases by other cells.
10024059
e
Metalloproteinases
QuestionChoice
Fibroblasts are involved in the synthesis of collagen and other extracellular matrix components, contributing to tissue repair and remodelling. They are not primarily responsible for tissue degradation.
10024058
d
Fibroblasts
QuestionChoice
During the late phase of wound healing, activated leukocytes and macrophages produce various factors, including cytokines, that contribute to the degradation of damaged tissue by influencing various processes, including the production of metalloproteinases by other cells. The cytokine IL-1 is indeed one of these factors. TNF is also another factor of note.
10024055
a
Cytokine IL1
Concept
Chapter
2693
5726
Wound Healing
Topic
286
Infection/ Inflammation
17209
During the late phase of wound healing, which of the following are produced by activated leukocytes and macrophages, and contribute to the degradation of damaged tissue?
a