QuestionSBA
QuestionChoice
This is the pathophysiology of type 1 diabetes mellitus, where autoimmune destruction of the insulin-producing beta cells causes a deficiency of insulin, resulting in raised glucose levels.
10027142
b
Autoimmune destruction of the insulin-producing beta cells of the pancreas
QuestionChoice
Phaeochromocytoma is a rare catecholamine-secreting tumour resulting in dangerously high levels of noradrenaline and adrenaline in the blood. This results in severe hypertension, headaches, palpitations, sweating and anxiety.
10027143
c
A tumour secreting large amounts of catecholamines
QuestionChoice
This is the pathophysiology of Graves disease. Autoantibodies bind to the thyroid stimulating hormone receptor, stimulating the thyroid gland to produce abnormally high amounts of T3 and T4, which feedback to cause a low TSH level. This results in symptoms such as weight loss, tremor, tachycardia, diarrhoea and exophthalmos.
10027145
e
Autoimmune-mediated chronic stimulation of the thyroid stimulating hormone receptor, resulting in hyperthyroidism
QuestionChoice
This is the pathophysiology of coeliac disease, which is characterised by symptoms such as chronic diarrhoea, bloating and malabsorption. Coeliac disease is often associated with other autoimmune conditions.
10027144
d
Autoimmune disorder primarily affecting the small intestine, where an inflammatory response against gluten-derive peptides occurs
QuestionChoice
Addison’s disease presents with features such as lethargy, weakness, hypotension, hyperpigmentation, weight loss, nausea and vomiting, and is sometimes associated with other autoimmune conditions.
10027141
a
Autoimmune destruction of the adrenal glands, reducing the production of cortisol and aldosterone
Concept
Chapter
2693
5958
Adrenal insufficiency
Topic
170
Clinical Chemistry
17826
What is the pathophysiological process underlying Addison’s disease?
a