QuestionSBA
QuestionChoice
This is incorrect. Motor neuron disease presents with upper and lower motor neuron signs and is rarely seen in patients below the age of 40 years old. The typical presentation of motor neuron disease includes fasciculations, mixed upper and lower motor neuron signs and muscle wasting. Motor neuron disease does not involve sensory symptoms.
10004333
c
Motor Neuron Disease
QuestionChoice
This is incorrect. Becker's muscular dystrophy is an X-linked recessive genetic condition which has less severe problems than Duchenne muscular dystrophy. Patients with Becker's muscular dystrophy typically present after 10 years old with progressive muscle weakness and wasting. It typically affects males and can cause cardiomyopathy.
10004332
b
Becker's Muscular Dystrophy
QuestionChoice
This is incorrect. Duchenne muscular dystrophy is an X-linked recessive inherited disorder affecting the dystrophin genes. This typically presents in patients over the age of 5 years old with progressive proximal muscle weakness. Other signs include pseudohypertrophy of the calf muscles and Gower's sign where a child has to use their arms to aid in standing up from squatting.
10004335
e
Duchenne's Muscular Dystrophy
QuestionChoice
This is correct. Charcot-Marie-Tooth disease encompasses a group of inherited conditions that damage the peripheral nerves, mostly in the legs or arms. It is the most common hereditary peripheral neuropathy commonly resulting in a motor loss. Common features include foot drop, high-arched feet known as pes cavus, distal muscle weakness and wasting along with loss of sensation.
10004331
a
Charcot-Marie-Tooth Disease
QuestionChoice
This is incorrect. Myasthenia gravis typically presents with fatigability involving muscle weakness following repetitive use of the muscle or muscle weakness at the end of the day. This can involve extraocular muscle weakness resulting in diplopia.
10004334
d
Myasthenia Gravis
Concept
Chapter
2693
4268
Neuromuscular disorders
Topic
190
Musculoskeletal
13413
A 13-year-old boy presents to A+E with a loss in lower leg sensation and weakness in his lower legs. On examination, there is muscle wasting in his lower legs along with high arched feet.

Which of the following options is the most likely diagnosis?
a