QuestionSBA
QuestionChoice
Mutations in the CARD14 gene have been shown to be associated with psoriasis.
10003607
b
CARD14
QuestionChoice
Anti-synthetase antibodies, particularly anti-Jo-1, are associated with a type of polymyositis that includes respiratory involvement, Raynaud's syndrome and fever. It is also associated with the cutaneous variant of polymyositis, called dermatomyositis.
10003610
e
Anti-synthetase antibodies (Anti Jo-1)
QuestionChoice
HLA antigens are encoded by genes on chromosome 6. HLA-DR4 is associated with type 1 diabetes mellitus and rheumatoid arthritis.
10003609
d
HLA-DR4
QuestionChoice
HLA-DQ2 and HLA-DQ8 are important HLA antigens to remember as they are associated with coeliac disease. They are encoded by genes on chromosome 6.
10003608
c
HLA-DQ2 and HLA-DQ8
QuestionChoice
A mutation in the filaggrin gene has been implicated in up to 50% of eczema cases. FLG encodes filaggrin, a protein required for the skin to perform its role as an effective barrier. A deficiency in FLG is thought to allow antigens access through the skin where they can initiate an immune and inflammatory response.
10003606
a
Filaggrin gene
Concept
Chapter
2693
3982
Atopic Dermatitis
Topic
144
Dermatology
13268
A 3-year-old girl is brought to her GP by her mother. She complains of dryness, redness and scaling on her daughter's arms. Her daughter is constantly itching her arms. She is worried about a diagnosis of atopic eczema. The GP advises using emollients after bathing and avoiding triggers.

Which of the following options is most associated with atopic eczema?
a