QuestionSBA
QuestionChoice
A presentation of ankylosing spondylitis would normally describe back pain that gets better with exercise. It would not account for the rise in ALP levels, and therefore Paget's disease is a more likely diagnosis in this case.
10025153
d
Ankylosing spondylitis
QuestionChoice
This patient is presenting with bone pain and an isolated rise in their ALP levels which is typical of a diagnosis of Paget's disease. Paget’s disease may also be diagnosed on X-ray where you may find osteolysis or an increase in bone size.
10025150
a
Paget’s disease of the bone
QuestionChoice
If the patient had osteoporosis, this would produce a normal bone profile and would not account for the raised ALP. Paget's disease is more likely to account for the biochemical findings in this patient.
10025154
e
Osteoporosis
QuestionChoice
Gout would normally present with a single red, hot and swollen joint. Gout would not account for a raise in ALP, so is not the most likely diagnosis in this case.
10025152
c
Gout
QuestionChoice
Pseudogout would present as a single inflamed joint, and it usually affects the wrist or shoulder joints. It would not account for this patient’s high ALP, so is not the most likely diagnosis in this case.
10025151
b
Pseudogout
Concept
Chapter
2693
4617
Paget's Disease
Topic
170
Clinical Chemistry
17428
A 65-year-old female presents to the GP with bone pain that began eight months ago. A blood test reveals no abnormalities except for a raised alkaline phosphatase (ALP) level.

Which of the following is the most likely diagnosis?
a