QuestionSBA
QuestionChoice
SERCA working too hard is part of the pathophysiology of this process. However, it is not mutated in patients with malignant hyperthermia.
10000972
b
SERCA
QuestionChoice
Mutation to dystrophin gene is X-linked and can cause Duchenne muscular dystrophy.
10000974
d
Dystrophin
QuestionChoice
Nicotinic receptors are responsible for muscle contraction at the neuromuscular junction.
10000973
c
Nicotinic receptor
QuestionChoice
A mutation in ryanodine receptors means gas anaesthetic causes calcium release. This makes the SERCA work harder to pump more Ca2+ back into the sarcoplasmic reticulum. This consumes ATP, O2, and leads to the consequences of malignant hyperthermia.
10000971
a
Ryanodine receptor
QuestionChoice
Creatine kinase is an energy store for muscle contraction.
10000975
e
Creatine kinase
Concept
Chapter
2693
3860
Malignant hyperthermia
Topic
177
Anaesthetics and Intensive Care Medicine
12741
A patient for surgery is put under general anaesthetic using sevoflurane. They start to become tachypnoeic and pyrexic. Malignant hyperthermia is suspected.

Mutation to which structure is responsible for this condition?
a