QuestionSBA
QuestionChoice
This is a CYP450 enzyme inhibitor, not an inducer.
10027480
e
Isoniazid
QuestionChoice
This is a CYP450 enzyme inhibitor, not an inducer.
10027477
b
Grapefruit
QuestionChoice
This does not affect the CYP450 enzyme system.
10027479
d
Pyrazinamide
QuestionChoice
This does not affect the CYP450 enzyme system.
10027478
c
Ethambutol
QuestionChoice
Rifampicin is a hepatic enzyme (p450) inducer. Therefore it is important to check interactions with other medications such as oral contraceptives as this will greatly reduce the efficacy. Patients who are on oral contraceptives and rifampicin should be counselled to use alternative contraception during treatment.
10027476
a
Rifampicin
Concept
Chapter
2693
4473
Treatment of tuberculosis
Topic
223
Antibiotic pharmacology
17893
A 40 year old man presents to the Emergency Department with a 4 day history of a cough that is productive of green sputum. He has also noticed fevers and night sweats.

He is currently homeless and uses heroin recreationally, but takes no prescribed medications and has not seen a GP for many years.

Acid-fast bacilli are seen on sputum sample and interferon gamma release assay is positive for tuberculosis. A chest x-ray displays a cavitating lesion in the upper left lobe. The patient is started on the tuberculosis protocol.

Which of the following medications is a CYP450 inducer?
a