QuestionSBA
QuestionChoice
No, this is not the correct answer. Physiological levels of circulating adrenaline will bind to beta 2 receptors on vascular smooth muscle, leading to the vasodilation of arteries.
10007967
c
Beta 2 and G-alpha-S
QuestionChoice
No, this is not the correct answer. Physiological levels of circulating adrenaline will bind to beta 2 receptors on vascular smooth muscle, leading to the vasodilation of arteries.
10007968
d
Beta 2 and G-alpha-Q
QuestionChoice
No, this is not the correct answer. This is the incorrect G-protein.
10007966
b
Alpha 1 and G-alpha-S
QuestionChoice
Yes, this is the correct answer. At higher concentrations (for example due to EpiPen injection), adrenaline will bind to alpha 1 receptors on vascular smooth muscle, leading to stimulation of G-alpha-Q and vasoconstriction of arteries.
10007965
a
Alpha 1 and G-alpha-Q
QuestionChoice
No, this is not the correct answer. The beta 1 receptor is found within the cardiac muscle. Activation by noradrenaline would cause an increase in heart rate and an increase in the force of contraction generated by cardiac muscle.
10007969
e
Beta 1 and G-alpha-S
Concept
Chapter
2693
4561
G protein-coupled receptors
Topic
166
General pharmacological concepts
14140
A 7-year-old girl presents to A&E with severe shortness of breath following the accidental ingestion of a peanut. She has a known peanut allergy.

The heart rate and blood pressure of this patient is recorded:

Heart Rate 145 beats/min

Blood Pressure: 60/42 mmHg

Adrenaline is used in the management of an anaphylactic reaction, which leads to the vasoconstriction of arteries to maintain the patient's blood pressure. Adrenaline does this by binding to a G-protein coupled receptor on vascular smooth muscle cells.

Which of the following receptors does adrenaline bind to and which effector protein is stimulated?
a