QuestionSBA
QuestionChoice
Ibuprofen does not commonly cause weight gain.
50393
e
Ibuprofen 400mg PO TDS
QuestionChoice
Folic acid does not commonly cause weight gain.
50391
c
Folic acid 5mg PO once weekly
QuestionChoice
Salbutamol does not commonly cause weight gain.
50390
b
Salbutamol 200micrograms INH QDS
QuestionChoice
Methotrexate does not commonly cause weight gain.
50392
d
Methotrexate 20mg PO once weekly
QuestionChoice
Weight gain is a very common side effect of atypical antipsychotics. Olanzapine and clozapine are the atypical antipsychotics most likely to cause weight gain whereas atypical antipsychotics such as aripiprazole have a lower risk of causing weight gain.
50389
a
Olanzapine 10mg PO OD
Concept
Chapter
Osteoporosis, otherwise known as thin bones, is a condition associated with high risk of low trauma fractures due to reduced bone mineral density. Osteoclast activity exceeds osteoblast activity, meaning that bone resorption is occurring at a greater rate than bone formation.

**Symptoms and Signs**

- Generally asymptomatic until a fragility fracture occurs
- Back pain
- Kyphosis (stooped posture)
- Fragility fractures

**Risk factors**

- Female sex
- Increasing age
- Smoking
- Corticosteroid use
- Low BMI (< 20-25kg/m<sup>2</sup>)
- Low body weight (<58kg)
- Vitamin D deficiency

**Protective factors**

- Higher BMI
- Exercise - mechanical loading stimulates bone formation

**Diagnosis**
Osteoporosis can be detected on dual-energy x-ray absorptiometry (DEXA) scan.
A T score of < -2.5 indicates osteoporosis

**Management**

- Fall prevention
- Vitamin D and calcium supplementation
- Hormone replacement therapy (postmenopausal women)
- Oral bisphosphonates
2657
3661
Olanzapine commonly causes weight gain
Topic
90
Psychiatry
10132
Case Presentation: A 34-year-old gentleman attends his GP complaining of weight gain.  His regular medicines are listed (below).


**PH** Asthma, Schizophrenia, Rheumatoid Arthritis

**DH** Sertraline 50mg PO OD, Folic acid 5mg PO once weekly, Olanzapine 10mg PO OD, Methotrexate 20mg PO once weekly, Ibuprofen 400mg PO TDS

**On examination**

BP 129/69mmHg, HR 68, RR 14, Weight 89kg (84kg one month ago)

Question: Select the medication that is most likely to have contributed to this patient's weight gain.
a