QuestionSBA
QuestionChoice
Breast cancer is most commonly associated with mutations in the BRCA gene.
10005912
b
Breast
QuestionChoice
This is a benign tumour in the brain which can result in hormonal disruption and can press on the optic chiasm causing bitemporal hemianopia.

This can be associated with multiple endocrine neoplasia syndrome (MEN) type 1.
10005915
e
Pituitary Adenoma
QuestionChoice
These are small bumps that can be found under the skin and on nerve cells.

They are associated with Neurofibromatosis which is a group of genetic disorders that cause tumours on the nerve cells. This syndrome can also be associated with cafe au lait spots on the skin usually present in childhood.
10005914
d
Neurofibromas
QuestionChoice
Cancers in the small intestine can be associated with Familial adenomatous polyposis (FAP).

This syndrome is due to mutations in the APC gene that regulates cell proliferation. This results in many polyps throughout the large intestine that can turn cancerous with an additional mutation.

This syndrome can also be associated with upper gastrointestinal cancers including those within the duodenum.
10005913
c
Duodenal
QuestionChoice
The cancers associated with lynch syndrome which results from mutation from the mismatch repair genes include ovarian and uterine, urinary tract, colorectal, stomach and pancreas.

Ovarian along with breast and pancreatic can also be associated with inheritance of the BRCA mutations.
10005911
a
Ovarian
Concept
Chapter
2693
3731
Colorectal Cancer
Topic
136
Gastroenterology
13729
A 30 year old attends clinic for a colonoscopy as he has a strong family history of bowel and pancreatic cancer and has recently experienced change in bowel habit with rectal bleeding.

During the procedure, 15 polyps were found.

The consultant is concerned that the family may have a mutation in the mismatch repair genes and have hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome. This can predispose to colon cancer as well as other malignancies in men and women.

Which of these cancers in females are also associated with this syndrome?
a