QuestionSBA
QuestionChoice
This potassium-sparing diuretic is commonly associated with gynaecomastia. It is thought to have anti-androgenic effects by preventing testosterone binding to androgen receptors in breast tissue and causing increased clearance of testosterone.
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a
Spironolactone
QuestionChoice
ACE inhibitors are not associated with gynaecomastia.
10028357
b
Ramipril
QuestionChoice
This is typically prescribed as an alternative in patients who experience spironolactone-induced gynaecomastia. The patient would be unlikely to be taking the two drugs simultaneously.
10028358
c
Amiloride
QuestionChoice
Whilst 5 alpha-reductase inhibitors can cause gynaecomastia, the patient has no history of BPH mentioned and would therefore be unlikely to be taking this medication.
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e
Finasteride
QuestionChoice
Statins are not typically associated with gynaecomastia.
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d
Atorvastatin
Concept
Chapter
2693
6056
Gynaecomastia
Topic
133
Endocrinology
18069
Spironolactone can cause gynaecomastia due to its anti-androgenic effects, as it blocks androgen receptors and inhibits the conversion of testosterone to its more active form, leading to an imbalance that promotes breast tissue growth in males
A 67-year-old male has noticed tenderness and swelling of his breast tissue in recent months

He has a past medical history of drug resistant hypertension and raised cholesterol.

Which of the following medications is the most likely cause of his symptoms?
a