QuestionSBA
QuestionChoice
This is associated with an increased risk of breast and ovarian cancers.
10005733
c
BRCA 1
QuestionChoice
This is a fusion gene caused by a translocation between chromosomes 9 and 22 and is associated with chronic myeloid leukaemia.
10005734
d
BCR-ABL1
QuestionChoice
Mutation of this gene causes cystic fibrosis
10005735
e
CFTR
QuestionChoice
This is associated with Lynch syndrome/hereditary non-polyposis colorectal cancer, which is also associated with colorectal cancer.
10005732
b
MSH2
QuestionChoice
This APC gene codes for a tumour suppressor protein. When the gene is mutated, this function is lost, increasing the risk of cancer.
10005731
a
APC (adenomatous polyposis coli)
Concept
Chapter
2693
4443
Colorectal cancer
Topic
225
Oncology and Palliative Care
13693
A 45-year-old man is on the ward with advanced colorectal cancer. He explains to you that he has an inherited condition that puts him at significantly higher risk of bowel cancer called familial adenomatous polyposis.

Which of the genes is mutated in this condition?
a