QuestionSBA
QuestionChoice
This is not the correct answer. A random blood glucose of ≥ 11.1mmol/l or fasting plasma glucose of ≥ 7mmol/l is one of the results which is sufficient for diagnosis of type 1 diabetes mellitus in symptomatic patients. However, it does not assess endogenous insulin production.
10027305
e
Random blood glucose and Fasting plasma glucose
QuestionChoice
This is not the correct answer. The presence of urinary ketones may suggest concurrent DKA. It does not assess endogenous insulin production.
10027304
d
Urine ketones
QuestionChoice
This is not the correct answer. A HbA1C of ≥ 48mmol/mol (6.5%) is one of the results which is sufficient for diagnosis of type 1 diabetes mellitus in symptomatic patients. However, it does not assess endogenous insulin production.
10027302
b
HbA1c
QuestionChoice
This is not the correct answer. Identification of specific antibodies (e.g. anti-GAD, ICA, IAA) helps in confirming the diagnosis of type 1 diabetes mellitus as it indicates the autoimmune nature. However, it is not part of the diagnostic criteria and it does not assess endogenous insulin production.
10027303
c
Auto-antibodies testing
QuestionChoice
This is the correct answer. C-peptide and insulin are packaged into vesicles in the Golgi apparatus and are secreted in equal concentrations. As such, low C-peptide levels would indicate low endogenous insulin levels, which is characteristic of type 1 diabetes mellitus as it is an autoimmune condition where the destruction of insulin-producing beta cells in the pancreas results in insulin deficiency.
10027301
a
C-peptide levels
Concept
Chapter
2693
5968
Diabetes Mellitus Type 1
Topic
133
Endocrinology
17858
An 18-year-old male is visiting his GP for an army medical assessment. He is normal weight, but complains of polyuria, fatigue and weight loss without trying. His sister and mother have type one diabetes.

Which of the following investigations can help assess his endogenous insulin production?
a