QuestionSBA
QuestionChoice
These findings are indicative of haemophilia A, an X-linked inherited bleeding disorder caused by a deficiency in factor VIII. The bleeding time is normal because it measures the response of platelets to vascular injury which is not affected in Haemophilia A.
10001405
d
PT normal, APTT increased, factor VIII activity decreased, bleeding time normal
QuestionChoice
Normally, Von Willebrand factor (VWF) protects factor VIII from proteolysis and enables contact between platelets and an injured vessel wall. In Von Willebrand disease (VWD), there are abnormalities in VWF which prevent this process from taking place. This results in reduced factor VIII activity.
10001403
b
PT normal, APTT increased, factor VIII activity normal, bleeding time prolonged
QuestionChoice
This is indicative of DIC in which there is dysregulated blood clotting, resulting in increased PT, APTT and bleeding time.
10001404
c
PT increased, APTT increased, factor VIII activity normal, bleeding time prolonged
QuestionChoice
In Von Willebrand disease (VWD), the prothrombin time is normal because the extrinsic pathway of the clotting cascade is unaffected.
10001406
e
PT increased, APTT increased, factor VIII activity decreased, bleeding time prolonged
QuestionChoice
This patient is presenting with Von Willebrand disease (VWD). Patients with VWD have abnormalities in Von Willebrand factor (VWF) which normally aids the clotting process. In VWD, there is decreased factor VIII activity which results in a normal prothrombin time (PT) and prolonged activated partial thromboplastin time (APTT). Bleeding time is also prolonged because VWF normally enables platelets to bind to exposed epithelium, and the abnormal/absent VWF in VWD prevents this.
10001402
a
PT normal, APTT increased, factor VIII activity decreased, bleeding time prolonged
Concept
Chapter
2693
3924
von Willebrand disease
Topic
157
Haematology
12827
A 22-year-old female presents to her GP with complaints of heavy periods since the onset of menarche. She also reports lightheadedness and fatigue. She explains that her father has previously had episodes of prolonged bleeding and her twin sister also suffers from heavy periods.

Which of the following investigation findings is consistent with the most likely diagnosis?
a