QuestionSBA
QuestionChoice
This is an essential enzyme in the biosynthesis of cholesterol. Statins such as atorvastatin and simvastatin act on this enzyme to reduce serum cholesterol levels. It is not influenced by indomethacin.
10007052
b
HMG-CoA reductase
QuestionChoice
This enzyme breaks down acetylcholine, a neurotransmitter that is key for neuronal signalling and is thought to be reduced in Alzheimer's disease. Drugs like donepezil and galantamine inhibit this enzyme, thus increasing levels of acetylcholine. It is not influenced by indomethacin.
10007053
c
Acetylcholinesterase
QuestionChoice
Ceruloplasmin is a copper carrying enzyme. Deficiency causes Wilson disease, in which copper is deposited around the body. It is not influenced by indomethacin.
10007055
e
Ceruloplasmin
QuestionChoice
Indomethacin is a non-steroidal anti-inflammatory (NSAID) medication. It inhibits the production of prostaglandins by inhibiting the enzyme cox-2. Prostaglandins are increased in inflammatory states and are associated with pain, fever, immunosuppression, clotting, and vasoconstriction. They can also inhibit the closure of a PDA, making indomethacin a helpful treatment option in preterm infants with PDA.
10007051
a
Cyclo-oxygenase 2
QuestionChoice
Monoamine oxidases (MOAs) are a family of enzymes involved in removing serotonin, dopamine, and norepinephrine from the brain. MOA-inhibitors are used to treat conditions in which serotonin, dopamine and norepinephrine are dysregulated: particularly depression and Parkinson's disease. Selegiline is an example of a MOA-inhibitor. It is not influenced by indomethacin.
10007054
d
Monoamine oxidase
Concept
Chapter
2693
4563
Lipid Bilayer
Topic
181
Structure and Function of Cells
13957
A 3-hour-old baby has just been found to have a patent ductus arteriosus (PDA). The consultant opts to close this with indomethacin.

Indomethacin acts on which of the following enzymes?
a