QuestionSBA
QuestionChoice
This is the correct answer. Oestrogen can have an anti-apoptotic effect, which means it can reduce or inhibit the normal apoptosis of cells. This effect is particularly relevant in the context of cancer because apoptosis serves as a natural mechanism to eliminate damaged or potentially cancerous cells from the body.
10025415
a
Decreases apoptosis activity
QuestionChoice
Oestrogen is not typically associated with anti-inflammatory functions; it can promote inflammation in some cases of ovarian cancers. Oestrogen is involved in the initiation and progression of ovarian cancer. It also plays a role in increasing oncogenes and decreasing apoptosis and tumour suppressors in the ovaries.
10025417
c
Anti-inflammatory function
QuestionChoice
Oestrogen has been linked to decreasing tumour suppressors in ovarian cancer. Oestrogen is involved in the initiation and progression of ovarian cancer. It also plays a role in increasing oncogenes and decreasing apoptosis in the ovaries.
10025418
d
Increases tumour suppressors
QuestionChoice
Oestrogen is involved in the initiation and progression of ovarian cancer. It plays a role in transforming the ovarian cells; including the surface epithelial cells, germ cells and stromal cells into carcinogenic cells. It also plays a role in increasing oncogenes and decreasing apoptosis and tumour suppressors in the ovaries.
10025419
e
Decreases the risk of epithelial cell transformation
QuestionChoice
Oestrogen has been associated with stimulating the growth and proliferation of cells, rather than inhibiting or slowing down their proliferation. Oestrogen can have a proliferative effect on various tissues, including the ovaries. By contrast, progesterone slows down the proliferation of ovarian cells, as it represses oestrogen-induced gene expression.
10025416
b
Slows down the proliferation of ovarian cells
Concept
Chapter
2693
3843
Ovarian cancer
Topic
176
Gynaecology
17481
A 61 year old woman receives a new diagnosis of ovarian cancer. She is currently taking hormone replacement therapy that contains oestrogen, and wonders whether she should stop.

Which of the following best describes the role of oestrogen in the pathophysiology of ovarian cancer?
a