QuestionSBA
QuestionChoice
This is the first-line test used in the diagnosis of hyperaldosteronism. Although Conn’s syndrome and hyperaldosteronism can present with headaches and hypertension, the excess aldosterone will also cause increased urination and thirst as well as cramps due to hyperkalaemia.
10024232
c
Aldosterone:Renin ratio
QuestionChoice
This test is used in the workup of Cushing’s syndrome. Cushing's syndrome can present with central obesity, buffalo hump, moon face, proximal myopathy and hirsutism.
10024231
b
24-hour urinary cortisol
QuestionChoice
The most likely diagnosis is phaeochromocytoma, a catecholamine-secreting tumour associated with MEN2. Adrenaline and noradrenaline secretion from the phaeochromocytoma stimulates the sympathetic nervous system which leads to excess sweating, palpitations, headaches and increased blood pressure through arterial vasoconstriction. The gold-standard investigation is the measurement of plasma and urinary metanephrines, which are metabolites of adrenaline.
10024230
a
Plasma and urinary metanephrines
QuestionChoice
This test is used to diagnose Addison’s disease. Addison's typically presents with **hypotension**, weakness, hyperpigmentation and GI symptoms such as nausea, vomiting and abdominal pain. There is no formal link between MEN2 and Addison's disease.
10024233
d
Short Synacthen test
QuestionChoice
Aldosterone concentration may be helpful in the diagnosis of hyperaldosteronism and adrenal insufficiency. However, it alone cannot confirm either diagnosis and is not indicated in this case.
10024234
e
Plasma aldosterone concentration
Concept
Chapter
2693
5759
Phaechromocytoma
Topic
133
Endocrinology
17244
A 30-year-old male presents to his GP with headache, sweating and abdominal pain. His father was previously diagnosed with multiple endocrine neoplasia 2 (MEN2). The GP measures his blood pressure and finds it to be 160/83.

Which of the following tests will confirm the diagnosis?
a