QuestionSBA
QuestionChoice
This answer is incorrect. Melatonin is a substance naturally produced in the body which promotes sleep through regulation of the sleep/wake cycle via melatonin receptors.
10007339
d
Melatonin
QuestionChoice
This answer is incorrect. Lorazepam is a benzodiazepine which acts to induce sleep via binding to benzodiazepine receptors on the postsynaptic GABA-A ligand-gated chloride ion channels.
10007338
c
Lorazepam
QuestionChoice
This answer is correct. Zopiclone is an example of a Z-drug that binds to the alpha-1 subunit of GABA receptors to increase GABA release and induce sleep.
10007336
a
Zopiclone
QuestionChoice
This answer is incorrect. Diphenhydramine is a first-generation antihistamine which acts as an inverse agonist at the H1 histamine receptor. It is used for insomnia due to its sedating properties.
10007337
b
Diphenhydramine
QuestionChoice
This answer is incorrect. Doxepin is a tricyclic antidepressant. One of its main side effects is sedation as it also antagonises the H1 receptor, and hence can be useful in insomnia.
10007340
e
Doxepin
Concept
Chapter
2693
4587
Zopiclone
Topic
172
Pharmacology of the Nervous System
14014
A 32-year-old woman attends a follow-up with her GP with a 10-day history of insomnia that is causing her significant daytime impairment. An initial trial of sleep hygiene measures has failed and the GP agrees to prescribe a short course of medication to help her sleep.

Which of the following medications induces sleep by increasing GABA release via binding to the alpha-1 subunit of GABA receptors?
a