QuestionSBA
QuestionChoice
Cushing's Disease occurs when symptoms of Cushing's Syndrome are caused by a pituitary tumour.

Symptoms of Cushing's Syndrome include low mood, central obesity (fat around the abdomen but not around the limbs), a red and puffy face, and red striae (stretch marks).

These symptoms are not what we are seeing in our patient - Cushing's disease is the incorrect diagnosis.
10001838
b
Cushing's Disease
QuestionChoice
Hashimoto's thyroiditis is also an autoimmune condition that affects the thyroid.

However, it causes hypothyroidism, not hyperthyroidism. This would result in symptoms such as fatigue, weight gain despite decreased appetite, low mood and cold intolerance.
10001840
d
Hashimoto's Thyroiditis
QuestionChoice
This patient's symptoms are consistent with a diagnosis of Graves' Disease.

Graves' Disease is an autoimmune condition where the body produces high levels of antibodies binding to the TSH receptors, activating them. The body responds by increasing its production of Thyroxine, leading to symptoms of hyperthyroidism such as heat-intolerance, diarrhoea, tremors and agitation.

TSH receptors are also found at the back of the eye, on the shins. Graves' disease causes an accumulation of hormone behind these structures too - leading to exophthalmos and pretibial myxoedema.
10001837
a
Graves' Disease
QuestionChoice
Addison's Disease occurs when there is a decreased level of cortisol in the body.

This is the opposite of Cushing's syndrome - this can cause symptoms such as tanned skin, weight loss, decreased appetite and fatigue.
10001839
c
Addison's Disease
QuestionChoice
Conn's Syndrome occurs when a tumour produces increased levels of aldosterone in the body. This increases serum sodium, leading to hypertension (high blood pressure) and hypokalaemia (low potassium levels).
10001841
e
Conn's Syndrome
Concept
Chapter
2693
3959
Hyperthyroidism
Topic
133
Endocrinology
12914
A 32-year-old woman presents to General Practice with exophthalmos, pretibial myxoedema and a tremor.

Which of the following is the most likely diagnosis?
a