QuestionSBA
QuestionChoice
Correct. This is the pathophysiology of sickle cell crisis and can lead to ischaemia of vital organs.
10002876
a
Abnormal red blood cells stick together and cause clotting in the microvasculature across the body
QuestionChoice
Incorrect. This describes the pathophysiology of disseminated intravascular coagulation.
10002880
e
Inappropriate activation of clotting cascade, leading to thrombus formation and depletion of clotting factors
QuestionChoice
Incorrect. This is not the pathophysiology of vaso-occlusive crisis
10002877
b
Blood flows too slowly through the vessels, causing irritation to the vessels
QuestionChoice
Incorrect. This describes why the red blood cells have a sickle shape, but it is not the direct cause of the crisis.
10002878
c
Crystals form in blood cells, enabling polymers to form
QuestionChoice
Incorrect. This describes paroxysmal nocturnal haemoglobinuria.
10002879
d
Haemolysis occurs due to an abnormal glycoprotein on the surface of red blood cells
Concept
Chapter
2693
3921
sickle cell disease
Topic
157
Haematology
13122
8 year old female with pre-existing sickle cell anaemia presents with intense pain and is found to be in a vaso-occlusive crisis.

What is the pathophysiology of vaso-occlusive crisis?
a