QuestionSBA
QuestionChoice
This is incorrect as GTN is broken down to release nitric oxide, not endothelins. Furthermore, since angina is caused by a reduction in blood flow to the heart, GTN must cause smooth muscle relaxation and hence vasodilation.
10026328
d
GTN is broken down to release endothelins. This causes activation of Ca2+ channels and hence contraction of smooth muscle cells
QuestionChoice
This is incorrect as GTN is broken down to release nitric oxide, not prostaglandins. Furthermore, since angina is caused by a reduction in blood flow to the heart, GTN must cause smooth muscle relaxation and hence vasodilation.
10026329
e
GTN is broken down to release prostaglandins. This causes activation of Ca2+ channels and hence contraction of smooth muscle cells
QuestionChoice
This is correct. Once inside the body, GTN is broken down to release nitric oxide, a potent vasodilator. Via increasing levels of intracellular cGMP, nitric oxide results in inhibition of Ca2+ channels, reducing intracellular Ca2+ and hence lowering smooth muscle contractility. This causes vasodilation and hence improves the symptoms of angina.
10026325
a
GTN is broken down to release nitric oxide which increases cGMP levels. This causes inhibition of Ca2+ channels and hence relaxation of smooth muscle cells
QuestionChoice
This is incorrect as nitric oxide increases, not decreases, the levels of cGMP. Via increasing levels of intracellular cGMP, nitric oxide results in inhibition of Ca2+ channels, reducing intracellular Ca2+ and hence lowering smooth muscle contractility. This causes vasodilation and hence improves the symptoms of angina.
10026326
b
GTN is broken down to release nitric oxide which decreases cGMP levels. This causes inhibition of Ca2+ channels and hence relaxation of smooth muscle cells
QuestionChoice
This is incorrect as GTN is broken down to release nitric oxide, not prostaglandins.
10026327
c
GTN is broken down to release prostaglandins. This causes inhibition of Ca2+ channels and hence relaxation of smooth muscle cells
Concept
Chapter
2693
3721
Stable angina
Topic
134
Cardiology
17663
Which of the following correctly describes the mechanism through which Glyceryl trinitrate (GTN) spray treats angina symptoms?
a