QuestionSBA
QuestionChoice
Naproxen is a non-steroidal anti-inflammatory drug (NSAID). This class of drugs works through the inhibition of COX-1 enzymes in the gastrointestinal tract, disrupting prostaglandin secretion which usually has a cytoprotective effect on the gastric mucosa. Naproxen therefore increases the risk of gastric ulcers (peptic ulcer disease), and so is often prescribed with a proton pump inhibitor to reduce this risk.
10025510
a
Naproxen
QuestionChoice
Omeprazole is a proton pump inhibitor. It works by inhibiting gastric acid secretion, thus reducing the incidence of gastric ulceration. It can also be used in the management of Helicobacter Pylori (H. Pylori) disease. This option is therefore incorrect.
10025514
e
Omeprazole
QuestionChoice
Co-codamol is a combination drug consisting of paracetamol and the opioid codeine. Neither is commonly associated with damage to the gastric mucosa. This option is therefore incorrect.
10025511
b
Co-codamol
QuestionChoice
Amoxicillin is an antibiotic. It is not commonly associated with damage to the gastric mucosa. It can, however, be used in the management of Helicobacter Pylori (H. Pylori) disease, reducing the incidence of gastric ulceration. This option is therefore incorrect.
10025512
c
Amoxicillin
QuestionChoice
Salbutamol is a beta-2 agonist typically used in the management of conditions such as asthma & chronic obstructive pulmonary disorder (COPD). It is not thought to contribute to gastric ulcer formation. This option is therefore incorrect.
10025513
d
Salbutamol
Concept
Chapter
2693
4052
Peptic ulcer disease
Topic
136
Gastroenterology
17500
A 35 year old woman discusses the results of a recent endoscopy with her GP. It notes the presence of multiple gastric ulcers.

She has been experiencing symptoms of dyspepsia for the past 6 months. She also suffers with chronic back pain and asthma, for which she takes a range of prescribed medications.

Which of the following repeat prescriptions is most likely to have contributed to her gastric ulcers?
a