QuestionSBA
QuestionChoice
Paracetamol is not associated with nephrotoxicity. However, in large doses or prolonged use, it can cause hepatic damage.
10025772
c
Paracetamol
QuestionChoice
Amoxicillin is not commonly associated with nephrotoxicity and is therefore not the single best answer. Penicillins are often associated with gastrointestinal upset and allergy. There is some association between beta-lactams and acute interstitial nephritis, however, this is less common than the nephrotoxic effect of gentamycin. Furthermore, the antibiotic in this case was prescribed to treat a pseudomonas infection, which amoxicillin does not cover.
10025771
b
Amoxicillin
QuestionChoice
Clarithromycin is a macrolide antibiotic and is often used when a patient has a penicillin allergy. It is associated with QT interval prolongation, gastrointestinal upset and ototoxicity, but not nephrotoxicity. This is therefore not the single best answer.
10025774
e
Clarithromycin
QuestionChoice
Whilst intravenous sodium chloride may have been used in the treatment of a severe infection, it is not commonly associated with nephrotoxicity. Therefore this is not the single best answer.
10025773
d
Intravenous sodium chloride
QuestionChoice
Gentamicin belongs to the aminoglycoside class of antibiotics. These drugs are associated with nephrotoxicity and ototoxicity. It is important to measure renal function regularly whilst on this medication.  They cause kidney damage through toxicity to tubular cells, causing acute tubular necrosis. Additionally, they are often used in severe infections caused by pseudomonas.
10025770
a
Gentamicin
Concept
Chapter
2693
4471
Aminoglycosides
Topic
223
Antibiotic pharmacology
17552
A 40 year old man attends his GP surgery requesting a blood test to measure his kidney function. He was discharged from hospital the previous week, after receiving a course of intravenous medications for a severe pseudomonas infection. He is unable to remember which medication he received but recalls one of the doctors warned him it could damage his kidneys.

Which of the following medications is most commonly associated with nephrotoxicity?
a