QuestionQA
Concept
Chapter
Osteoporosis, otherwise known as thin bones, is a condition associated with high risk of low trauma fractures due to reduced bone mineral density. Osteoclast activity exceeds osteoblast activity, meaning that bone resorption is occurring at a greater rate than bone formation.

**Symptoms and Signs**

- Generally asymptomatic until a fragility fracture occurs
- Back pain
- Kyphosis (stooped posture)
- Fragility fractures

**Risk factors**

- Female sex
- Increasing age
- Smoking
- Corticosteroid use
- Low BMI (< 20-25kg/m<sup>2</sup>)
- Low body weight (<58kg)
- Vitamin D deficiency

**Protective factors**

- Higher BMI
- Exercise - mechanical loading stimulates bone formation

**Diagnosis**
Osteoporosis can be detected on dual-energy x-ray absorptiometry (DEXA) scan.
A T score of < -2.5 indicates osteoporosis

**Management**

- Fall prevention
- Vitamin D and calcium supplementation
- Hormone replacement therapy (postmenopausal women)
- Oral bisphosphonates
2657
3675
Gentamicin dosing
Topic
13
Neurosurgery
This question asks for the maximum dose possible therefore the answer would be (95 x 7) which is 665mg.
10146
QuestionQAAnswer
665
mg
 

Case Presentation: A 52-year-old patient has been admitted to the general surgical ward due to an episode of acute diverticulitis. They are prescribed antibiotics for this infection, one of which is a STAT dose of gentamicin. Gentamicin can be given IV 5-7mg/kg once daily at a maximum of 7mg/kg. He weighs 95kg.

What is the maximum dose of gentamicin that this gentleman should receive in one day.