QuestionSBA
QuestionChoice
Non-caseating granulomas are another hallmark of Crohn's disease. Ulcerative colitis does not feature granulomas, indeed the BMJ cite the absence of granulomas as an indication of ulcerative colitis over Crohn's disease.
10000269
d
Presence of granulomas
QuestionChoice
Cobblestone inflammation is not a histopathological sign but an endoscopic sign found in Crohn's disease that occurs when fissures/ulceration leaves elevated patches of mucosa.
10000270
e
Cobblestone inflammation
QuestionChoice
Skip lesions are a classic histopathological sign of Crohn's disease. Ulcerative colitis on the other hand manifests as continuous inflammation extending proximally from the rectum.
10000268
c
Skip lesions
QuestionChoice
Diverticula are a hallmark of diverticulosis and occur when pouches of colonic mucosa herniate through the muscular layer of the colon wall. They are often asymptomatic but can become problematic in diverticular disease and diverticulitis.
10000267
b
Diverticula
QuestionChoice
In ulcerative colitis, inflammation is typically limited to the mucosa and submucosa unless in fulminant disease. This is different from Crohn's disease which typically involves transmural inflammation. Other histopathological hallmarks of ulcerative colitis include continuous inflammation, goblet cell depletion,  and crypt abscesses.
10000266
a
Inflammation is limited to mucosa and submucosa
Concept
Chapter
2693
3732
Ulcerative Colitis
Topic
136
Gastroenterology
12600
A 24-year-old female presents to clinic and reports a 5-week history of bloody diarrhoea and weight loss. You suspect inflammatory bowel disease and request a colonoscopy and biopsy.

Which histopathological sign would be most indicative of ulcerative colitis?
a