QuestionSBA
QuestionChoice
The nicotinic acetylcholine receptors at the neuromuscular junction are ligand-gated ion channels, not G-protein coupled receptors. G-protein coupled receptors have a longer activation-to-effect time, which would not be useful at the neuromuscular junction, which needs to be able to respond quickly when activated.
10004742
b
Ligand binding causes a conformational change which activates an intracellular G-protein
QuestionChoice
This is the structure of G-protein coupled receptors. Nicotinic acetylcholine receptors consist of 5 subunits, each with 4 transmembrane domains, surrounding a central pore.
10004745
e
They are monomeric receptors consisting of seven transmembrane domains
QuestionChoice
Glutamate is the primary excitatory neurotransmitter in the central nervous system. The neuromuscular junction contains nicotinic receptors, which are activated by acetylcholine released from the presynaptic neuron.
10004743
c
They are activated by glutamate
QuestionChoice
Nicotinic acetylcholine receptors are found in the neuromuscular junction and are ligand-gated ion channels. Following their activation by acetylcholine, the central channel opens, allowing sodium ions to enter the cell and potassium ions to exit the cell.
10004741
a
They are permeable to cations such as Na+ and K+
QuestionChoice
Suxamethonium is a nicotinic agonist- it activates the nicotinic receptors at the neuromuscular junction, not blocks them.
10004744
d
They are blocked by suxamethonium
Concept
Chapter
2693
3820
Neuromuscular junction
Topic
152
Neuroscience
13495
Which statement best describes a feature of the post-synaptic receptors found at the neuromuscular junction?
a