QuestionSBA
QuestionChoice
In haemophilia A, there is a deficiency of factor VIII, not VII. Factor VII combines with tissue factor in the extrinsic pathway to initiate the coagulation cascade via factor X.
10023612
c
Clotting factor VII which affects the extrinsic pathway
QuestionChoice
Haemophilia A occurs due to a deficiency in clotting factor VIII. Factor VIII is part of the intrinsic pathway and has many downstream effects, including increasing the conversion of factor XIII to factor XIIIa, and increasing the conversion of fibrin into a fibrin clot.
10023610
a
Clotting factor VIII which affects the intrinsic pathway
QuestionChoice
In haemophilia A, there is a deficiency of factor VIII, not II. Factor II (thrombin) activates fibrinogen to form fibrin in the intrinsic pathway, which helps with the formation of a clot.
10023613
d
Clotting factor II which affects the the intrinsic pathway
QuestionChoice
In haemophilia A, there is a deficiency in factor VIII, not XI. Factor XI deficiency is called haemophilia C. Both haemophilia A and C play a role in the intrinsic pathway.
10023614
e
Clotting factor XI which affects the intrinsic pathway
QuestionChoice
There is indeed a deficiency in clotting factor VIII in haemophilia A, but it is the intrinsic coagulation pathway that is affected, not the extrinsic pathway.
10023611
b
Clotting factor VIII which affects the extrinsic pathway
Concept
Chapter
2693
5689
Coagulation Cascade
Topic
193
Haematological Science
17120
A 24-year-old female presents to the ED with prolonged bleeding after a small cut on her leg. She has tried to put pressure on the wound but it has not helped. She is not on any anticoagulant medications.

It is found that she has haemophilia A.

Which molecule is depleted in haemophilia A and which pathway of the coagulation cascade does this affect?
a