QuestionSBA
QuestionChoice
This is a disorder of iron metabolism where excessive iron accumulates in the body and is deposited in a number of sites including the liver, heart, joints, pancreas and skin. You would expect haemochromatosis to show deranged LFTs as well as a raised serum ferritin and raised transferring saturation.
10007613
c
Haemochromatosis
QuestionChoice
You would expect pancreatitis to present with symptoms like epigastric pain radiating to the back, pain relived by sitting forward and nausea and vomiting. Bloods may show leukocytosis and an extremely high amylase level.
10007614
d
Acute Pancreatitis
QuestionChoice
You would expect Wilson's disease to show low serum ceruloplasmin and copper levels. It would not account for the high ALT.
10007615
e
Wilson’s disease
QuestionChoice
You would expect Gilbert’s syndrome to cause a mildly raised bilirubin but otherwise normal blood results. It would not account for the raised ALP. Gilbert’s can cause a mild intermittent jaundice in relation to stress, infection, fasting, or exercise.
10007612
b
Gilbert’s syndrome
QuestionChoice
An isolated raised ALP is indicative of alpha-1 antitrypsin deficiency. This is an inherited condition that affects the lungs (causing emphysema) and the liver (causing cirrhosis and hepatocellular carcinoma).
10007611
a
Alpha-1 Antitrypsin deficiency
Concept
Chapter
2693
4593
Alpha-1 Antitrypsin Deficiency
Topic
136
Gastroenterology
14069
A 46-year-old male attends his GP surgery with concerns that he is becoming more short of breath on exertion. He undergoes blood tests, which demonstrate a raised ALT at 68IU/L (normal range 10-50 IU/L). Bilirubin, ALP and albumin are all within the normal range.


He does not drink alcohol and his BMI is 24. His father has emphysema.


Which of the following is the most likely reason for this liver abnormality?
a